ntp.niehs.nih.gov · f2_m3 c number: c20009 lock date: 05/05/2008 cage range: all date range: all...
TRANSCRIPT
F2_M3C Number: C20009
Lock Date: 05/05/2008
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.4.1.0_004
PWG Approval Date: 12/14/2010
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
Note: Animals arranged according to days on test.
DAY ON TEST
B6C3F1 MICE MALE
0402
0441
0455
0455
0460
0505
0508
0519
0524
0543
0543
0562
0567
0585
0590
0594
0596
0613
0619
0624
0627
0646
0648
0670
0700
0 mg/lANIMAL ID
00030
00028
00014
00040
00041
00049
00005
00013
00048
00002
00018
00006
00026
00029
00031
00046
00027
00033
00017
00043
00009
00019
00039
00004
00012
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder A A A + + + A + + + A A A + + A A A A A A A + + +
Intestine Large, Cecum A A A + + + A A + + A A A + A A + A A A A A + + +
Intestine Large, Colon + + A + + + + + + + A A A + + A + A A A A A + + +
Intestine Large, Rectum A + A + + + + A + + A A A + + A + A A + A A + + +
Intestine Small, Duodenum A A A + + + + A A + A A A + + A + A A A A A + + +
Intestine Small, Ileum A + A + + + A A + + A A A + A A + A A A A A + + +
Intestine Small, Jejunum + A A + + + A A + + A A A + + A A A A A A A + + ACarcinoma X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X X X XHepatoblastoma X XHepatoblastoma, Multiple X XHepatocellular Adenoma X X X XHepatocellular Adenoma, Multiple X X X X X X XHepatocellular Carcinoma X X X X X X X X X XHepatocellular Carcinoma, Multiple X X X XHepatocholangiocarcinoma X
Mesentery + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Pancreas A + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 2
DAY ON TEST
B6C3F1 MICE MALE
0402
0441
0455
0455
0460
0505
0508
0519
0524
0543
0543
0562
0567
0585
0590
0594
0596
0613
0619
0624
0627
0646
0648
0670
0700
0 mg/lANIMAL ID
00030
00028
00014
00040
00041
00049
00005
00013
00048
00002
00018
00006
00026
00029
00031
00046
00027
00033
00017
00043
00009
00019
00039
00004
00012
males(cont...)
Hepatocholangiocarcinoma, Metastatic, Liver X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach A + + + + + A + + + + + + + + + + A + + + + + + +
Stomach, Glandular A + A + + + A + + + A A A + + + + A A + + + + + +
Tooth + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatocholangiocarcinoma, Metastatic, Liver XSarcoma, Metastatic, Uncertain Primary Site X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + A + + + + + +Subcapsular, Adenoma X
Adrenal Medulla + + + + + + + + + + + + + + + + + + A + + + + + +
Islets, Pancreatic A + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Parathyroid Gland + + + + + + M + + + + + + + + + M + M + M M M + +
Pituitary Gland + + + + + + + + + + + + + + + + + A M + + M + + +
Thyroid Gland A + + + + + + + + + + + + + + + + + + + + + + + +Follicular Cell, Adenoma
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 3
DAY ON TEST
B6C3F1 MICE MALE
0402
0441
0455
0455
0460
0505
0508
0519
0524
0543
0543
0562
0567
0585
0590
0594
0596
0613
0619
0624
0627
0646
0648
0670
0700
0 mg/lANIMAL ID
00030
00028
00014
00040
00041
00049
00005
00013
00048
00002
00018
00006
00026
00029
00031
00046
00027
00033
00017
00043
00009
00019
00039
00004
00012
males(cont...)
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland +
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + A + + + + + + + A A + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X X
Lymph Node +Mediastinal, Hepatocholangiocarcinoma,
Metastatic, LiverX
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Rhabdomyosarcoma, Metastatic, Skeletal
Muscle
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 4
DAY ON TEST
B6C3F1 MICE MALE
0402
0441
0455
0455
0460
0505
0508
0519
0524
0543
0543
0562
0567
0585
0590
0594
0596
0613
0619
0624
0627
0646
0648
0670
0700
0 mg/lANIMAL ID
00030
00028
00014
00040
00041
00049
00005
00013
00048
00002
00018
00006
00026
00029
00031
00046
00027
00033
00017
00043
00009
00019
00039
00004
00012
males(cont...)
Lymph Node, Mesenteric + + + + + + + + + + + M + + + + + + + A A A + + +
Spleen A A + + + + + + + + + + A + + + + A + + + + + + +Hemangiosarcoma X
Thymus A + + + + + + + + + + + A + + + + A A + A + + + +Hepatocellular Carcinoma, Metastatic, Liver XHepatocholangiocarcinoma, Metastatic, Liver X
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrous HistiocytomaSubcutaneous Tissue, HemangiomaSubcutaneous Tissue, Hemangiosarcoma
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal MuscleRhabdomyosarcoma
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 5
DAY ON TEST
B6C3F1 MICE MALE
0402
0441
0455
0455
0460
0505
0508
0519
0524
0543
0543
0562
0567
0585
0590
0594
0596
0613
0619
0624
0627
0646
0648
0670
0700
0 mg/lANIMAL ID
00030
00028
00014
00040
00041
00049
00005
00013
00048
00002
00018
00006
00026
00029
00031
00046
00027
00033
00017
00043
00009
00019
00039
00004
00012
males(cont...)
Alveolar/Bronchiolar Carcinoma X X XCarcinoma, Metastatic, Harderian GlandHemangiosarcoma X XHepatoblastoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver X X X X X X XHepatocholangiocarcinoma, Metastatic, Liver XRhabdomyosarcoma, Metastatic, Skeletal
MuscleSarcoma, Metastatic, Uncertain Primary Site X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X
Trachea A + + + + + + + + + + + A + + + + A + + + + + + +
SPECIAL SENSES SYSTEM
Eye A + A + + + A A + + A A A + + A A A A A A A + + +
Harderian Gland + + A + + + + + + + + + + + + + + A A + + A + + +Adenoma X X XCarcinoma XRhabdomyosarcoma, Metastatic, Skeletal
Muscle
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X
Urethra + + +
Urinary Bladder A + + + + + + A + + + A + + + + + + A + A + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 6
DAY ON TEST
B6C3F1 MICE MALE
0402
0441
0455
0455
0460
0505
0508
0519
0524
0543
0543
0562
0567
0585
0590
0594
0596
0613
0619
0624
0627
0646
0648
0670
0700
0 mg/lANIMAL ID
00030
00028
00014
00040
00041
00049
00005
00013
00048
00002
00018
00006
00026
00029
00031
00046
00027
00033
00017
00043
00009
00019
00039
00004
00012
males(cont...)
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Mesothelioma Benign X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 7
DAY ON TEST
B6C3F1 MICE MALE
0717
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 mg/lANIMAL ID
00047
00016
00001
00010
00011
00015
00020
00024
00036
00037
00038
00042
00044
00045
00050
00003
00007
00008
00021
00022
00023
00025
00032
00034
00035 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 35
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 40
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 39
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 35Carcinoma X 2
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 5Hepatoblastoma X 3Hepatoblastoma, Multiple X 3Hepatocellular Adenoma X X X X X X X X 12Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X 21Hepatocellular Carcinoma X X X X X X X X X X 20Hepatocellular Carcinoma, Multiple X X 6Hepatocholangiocarcinoma X 2
Mesentery + + + + 7Hepatocholangiocarcinoma, Metastatic, Liver 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 49
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 8
DAY ON TEST
B6C3F1 MICE MALE
0717
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 mg/lANIMAL ID
00047
00016
00001
00010
00011
00015
00020
00024
00036
00037
00038
00042
00044
00045
00050
00003
00007
00008
00021
00022
00023
00025
00032
00034
00035 * TOTALS
Hepatocholangiocarcinoma, Metastatic, Liver 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 47
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 42
Tooth + + + + + + + + + + + + + + + + + + + + 35
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1Hepatocholangiocarcinoma, Metastatic, Liver 1Sarcoma, Metastatic, Uncertain Primary Site 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 49Subcapsular, Adenoma X 2
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 49
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 49Adenoma 1
Parathyroid Gland M + + M M + + + + M + + M + + M + + + + M + + + + 37
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Follicular Cell, Adenoma X 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 9
DAY ON TEST
B6C3F1 MICE MALE
0717
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 mg/lANIMAL ID
00047
00016
00001
00010
00011
00015
00020
00024
00036
00037
00038
00042
00044
00045
00050
00003
00007
00008
00021
00022
00023
00025
00032
00034
00035 * TOTALS
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland + 2
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocholangiocarcinoma, Metastatic, Liver 1
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 47Hepatocholangiocarcinoma, Metastatic, Liver 1
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 2
Lymph Node + 2Mediastinal, Hepatocholangiocarcinoma,
Metastatic, Liver 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50Rhabdomyosarcoma, Metastatic, Skeletal
MuscleX 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 10
DAY ON TEST
B6C3F1 MICE MALE
0717
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 mg/lANIMAL ID
00047
00016
00001
00010
00011
00015
00020
00024
00036
00037
00038
00042
00044
00045
00050
00003
00007
00008
00021
00022
00023
00025
00032
00034
00035 * TOTALS
Lymph Node, Mesenteric M + + + + + + + + + + + + + + + + + + + + + + + + 45
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 46Hemangiosarcoma 1
Thymus + + + + + M + + + + M + + + + + + + + + + + + M M 41Hepatocellular Carcinoma, Metastatic, Liver 1Hepatocholangiocarcinoma, Metastatic, Liver 1
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrous Histiocytoma X 1Subcutaneous Tissue, Hemangioma X 1Subcutaneous Tissue, Hemangiosarcoma X 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle + 1Rhabdomyosarcoma X 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X X 6
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 11
DAY ON TEST
B6C3F1 MICE MALE
0717
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 mg/lANIMAL ID
00047
00016
00001
00010
00011
00015
00020
00024
00036
00037
00038
00042
00044
00045
00050
00003
00007
00008
00021
00022
00023
00025
00032
00034
00035 * TOTALS
Alveolar/Bronchiolar Carcinoma X X X X X X 9Carcinoma, Metastatic, Harderian Gland X 1Hemangiosarcoma 2Hepatoblastoma, Metastatic, Liver X 2Hepatocellular Carcinoma, Metastatic, Liver X X X X X X X 14Hepatocholangiocarcinoma, Metastatic, Liver 1Rhabdomyosarcoma, Metastatic, Skeletal
MuscleX 1
Sarcoma, Metastatic, Uncertain Primary Site 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 47
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 36
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 46Adenoma X X 5Carcinoma X 2Rhabdomyosarcoma, Metastatic, Skeletal
MuscleX 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Carcinoma, Metastatic, Liver 1
Urethra 3
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 45
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 12
DAY ON TEST
B6C3F1 MICE MALE
0717
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 mg/lANIMAL ID
00047
00016
00001
00010
00011
00015
00020
00024
00036
00037
00038
00042
00044
00045
00050
00003
00007
00008
00021
00022
00023
00025
00032
00034
00035 * TOTALS
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Mesothelioma Benign 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 13
DAY ON TEST
B6C3F1 MICE MALE
0407
0470
0512
0545
0580
0583
0585
0593
0593
0605
0614
0621
0627
0627
0627
0632
0638
0642
0675
0690
0702
0704
0715
0722
0730
312.5 mg/lANIMAL ID
00074
00071
00091
00070
00064
00059
00086
00055
00092
00069
00083
00099
00061
00080
00089
00098
00072
00052
00094
00067
00096
00088
00054
00095
00063
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder A + A A + A + A + A A A A + A A A + + A + A A A +
Intestine Large, Cecum A A A A + A + A + A + A A + A + A A + A A A A + +
Intestine Large, Colon A A A + + + + + + A + A A + A + A + + A + + A + +Sarcoma, Metastatic, Liver X
Intestine Large, Rectum A A A + + + + + + A A A A + A + A A + A + + A + +
Intestine Small, Duodenum A A A + + A + A A A A A A + A A A A + A A A A A +
Intestine Small, Ileum A A A + + A + A + A + A A + A + A A + A A A A + +
Intestine Small, Jejunum A A A + + A + A + A A A A + A A A A + A A A A A +AdenomaCarcinoma
Liver + + + + + + + + + + + + + + + + + + + + + + + + +HemangiomaHemangiosarcoma X X XHepatoblastoma X XHepatoblastoma, Multiple XHepatocellular Adenoma X X X X X XHepatocellular Adenoma, Multiple X X X X X X X X X X X X XHepatocellular Carcinoma X X X X X XHepatocellular Carcinoma, Multiple X X X X X X XHepatocholangiocarcinoma XIto Cell Tumor Malignant X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 14
DAY ON TEST
B6C3F1 MICE MALE
0407
0470
0512
0545
0580
0583
0585
0593
0593
0605
0614
0621
0627
0627
0627
0632
0638
0642
0675
0690
0702
0704
0715
0722
0730
312.5 mg/lANIMAL ID
00074
00071
00091
00070
00064
00059
00086
00055
00092
00069
00083
00099
00061
00080
00089
00098
00072
00052
00094
00067
00096
00088
00054
00095
00063
males(cont...)
Sarcoma X
Mesentery
Pancreas A + + + + + + + + + + + + + + + + + + + + + A + +Sarcoma, Metastatic, Liver X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach A + + + + + + + + + + + A + + + + + + + + + A + +HemangiomaSquamous Cell Papilloma X
Stomach, Glandular A + + + + + + + + + + + A + + + + A + A + + A + +
Tooth + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatocellular Carcinoma, Metastatic, Liver X XSarcoma, Metastatic, Liver X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + A + A + + +Sarcoma, Metastatic, Liver XSubcapsular, Adenoma
Adrenal Medulla + + + + + + + + + + + + + + A + + + + A + A + + +
Islets, Pancreatic A + + + + + + + + + + + + + + + + + + + + + A + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 15
DAY ON TEST
B6C3F1 MICE MALE
0407
0470
0512
0545
0580
0583
0585
0593
0593
0605
0614
0621
0627
0627
0627
0632
0638
0642
0675
0690
0702
0704
0715
0722
0730
312.5 mg/lANIMAL ID
00074
00071
00091
00070
00064
00059
00086
00055
00092
00069
00083
00099
00061
00080
00089
00098
00072
00052
00094
00067
00096
00088
00054
00095
00063
males(cont...)
Parathyroid Gland + M + M M + + + + + + + + + M + + M + + + + + + M
Pituitary Gland A + + + + + + + + + + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Follicular Cell, Carcinoma X
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + A + + + + + + + + + + A + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Interstitial Cell, Adenoma
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node +Mediastinal, Hepatoblastoma, Metastatic, Liver X
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + A + +Carcinoma, Metastatic, Harderian Gland X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 16
DAY ON TEST
B6C3F1 MICE MALE
0407
0470
0512
0545
0580
0583
0585
0593
0593
0605
0614
0621
0627
0627
0627
0632
0638
0642
0675
0690
0702
0704
0715
0722
0730
312.5 mg/lANIMAL ID
00074
00071
00091
00070
00064
00059
00086
00055
00092
00069
00083
00099
00061
00080
00089
00098
00072
00052
00094
00067
00096
00088
00054
00095
00063
males(cont...)
Lymph Node, Mesenteric + + + + + + + + + + + A + + A + + + + A A + A + +Sarcoma, Metastatic, Liver X
Spleen A + + + + + + + + + + + + + + + + + + A + + + + +Hemangiosarcoma X
Thymus + + + + + + + + + M + + + + A + + + + A + M A + +Hemangiosarcoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver XHepatocholangiocarcinoma, Metastatic, LiverSarcoma, Metastatic, Liver X
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrous Histiocytoma XSubcutaneous Tissue, Sarcoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Liver X
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 17
DAY ON TEST
B6C3F1 MICE MALE
0407
0470
0512
0545
0580
0583
0585
0593
0593
0605
0614
0621
0627
0627
0627
0632
0638
0642
0675
0690
0702
0704
0715
0722
0730
312.5 mg/lANIMAL ID
00074
00071
00091
00070
00064
00059
00086
00055
00092
00069
00083
00099
00061
00080
00089
00098
00072
00052
00094
00067
00096
00088
00054
00095
00063
males(cont...)
Alveolar/Bronchiolar Carcinoma X X XAlveolar/Bronchiolar Carcinoma, Multiple XHemangiosarcoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver X X X X X X X XHepatocholangiocarcinoma, Metastatic, LiverSarcoma, Metastatic, Liver X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Pleura +Hepatocellular Carcinoma, Metastatic, Liver X
Trachea A + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye A A A + + + + + + A + A A + A + A + + A + + A A +
Harderian Gland + + + + + + + + + + + + + + A + + + + A + + A + +Adenoma XCarcinoma X X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Liver X
Urethra + + +
Urinary Bladder A A + + + + + + + + + A + + + + + + + A + + A + +
SYSTEMIC LESIONS
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 18
DAY ON TEST
B6C3F1 MICE MALE
0407
0470
0512
0545
0580
0583
0585
0593
0593
0605
0614
0621
0627
0627
0627
0632
0638
0642
0675
0690
0702
0704
0715
0722
0730
312.5 mg/lANIMAL ID
00074
00071
00091
00070
00064
00059
00086
00055
00092
00069
00083
00099
00061
00080
00089
00098
00072
00052
00094
00067
00096
00088
00054
00095
00063
males(cont...)
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 19
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
312.5 mg/lANIMAL ID
00075
00057
00062
00065
00068
00077
00078
00084
00085
00097
00051
00053
00056
00058
00060
00066
00073
00076
00079
00081
00082
00087
00090
00093
00100 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + M + + + + + + + + + + + + + + + + + + + + 33
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 34
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 40Sarcoma, Metastatic, Liver 1
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 38
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 31
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 35
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 32Adenoma X 1Carcinoma X 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangioma X 1Hemangiosarcoma X 4Hepatoblastoma X X X 5Hepatoblastoma, Multiple 1Hepatocellular Adenoma X X X X X 11Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X 30Hepatocellular Carcinoma X X X X X X X 13Hepatocellular Carcinoma, Multiple X X X 10Hepatocholangiocarcinoma X 2Ito Cell Tumor Malignant 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 20
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
312.5 mg/lANIMAL ID
00075
00057
00062
00065
00068
00077
00078
00084
00085
00097
00051
00053
00056
00058
00060
00066
00073
00076
00079
00081
00082
00087
00090
00093
00100 * TOTALS
Sarcoma 1
Mesentery + 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 48Sarcoma, Metastatic, Liver 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 47Hemangioma X 1Squamous Cell Papilloma 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 45
Tooth + + + + + + + + + + + + + + + + + + + + + + + 41
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1Hepatocellular Carcinoma, Metastatic, Liver 2Sarcoma, Metastatic, Liver 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 48Sarcoma, Metastatic, Liver 1Subcapsular, Adenoma X 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 47
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 48
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 21
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
312.5 mg/lANIMAL ID
00075
00057
00062
00065
00068
00077
00078
00084
00085
00097
00051
00053
00056
00058
00060
00066
00073
00076
00079
00081
00082
00087
00090
00093
00100 * TOTALS
Parathyroid Gland M M + + + + + + + + + M + + + + + + + M + M + + + 39
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Follicular Cell, Carcinoma 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 48
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Interstitial Cell, Adenoma X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node 1Mediastinal, Hepatoblastoma, Metastatic, Liver 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 49Carcinoma, Metastatic, Harderian Gland 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 22
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
312.5 mg/lANIMAL ID
00075
00057
00062
00065
00068
00077
00078
00084
00085
00097
00051
00053
00056
00058
00060
00066
00073
00076
00079
00081
00082
00087
00090
00093
00100 * TOTALS
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 45Sarcoma, Metastatic, Liver 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 48Hemangiosarcoma 1
Thymus + + + + + + + + M + + + + + + + + + M + + M + + + 42Hemangiosarcoma, Metastatic, Liver 1Hepatocellular Carcinoma, Metastatic, Liver 1Hepatocholangiocarcinoma, Metastatic, Liver X 1Sarcoma, Metastatic, Liver 1
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrous Histiocytoma X 2Subcutaneous Tissue, Sarcoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma, Metastatic, Liver 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X 11
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 23
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
312.5 mg/lANIMAL ID
00075
00057
00062
00065
00068
00077
00078
00084
00085
00097
00051
00053
00056
00058
00060
00066
00073
00076
00079
00081
00082
00087
00090
00093
00100 * TOTALS
Alveolar/Bronchiolar Carcinoma X X X X 7Alveolar/Bronchiolar Carcinoma, Multiple X 2Hemangiosarcoma, Metastatic, Liver 1Hepatocellular Carcinoma, Metastatic, Liver X X X X 12Hepatocholangiocarcinoma, Metastatic, Liver X 1Sarcoma, Metastatic, Liver 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Pleura 1Hepatocellular Carcinoma, Metastatic, Liver 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 49
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 39
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47Adenoma X X X X 5Carcinoma X X 4
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma, Metastatic, Liver 1
Urethra 3
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 45
SYSTEMIC LESIONS
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 24
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
312.5 mg/lANIMAL ID
00075
00057
00062
00065
00068
00077
00078
00084
00085
00097
00051
00053
00056
00058
00060
00066
00073
00076
00079
00081
00082
00087
00090
00093
00100 * TOTALS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Lymphoma Malignant X X 3
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 25
DAY ON TEST
B6C3F1 MICE MALE
0456
0470
0496
0519
0524
0526
0548
0551
0556
0560
0569
0627
0628
0631
0659
0661
0670
0685
0694
0700
0704
0707
0715
0730
0730
625 mg/lANIMAL ID
00108
00124
00137
00131
00123
00149
00104
00101
00115
00114
00106
00148
00122
00145
00139
00127
00133
00150
00105
00118
00144
00132
00129
00113
00117
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + A + A A + A A A A + + + + A + + A + + A A + +
Intestine Large, Cecum + + A A A A A + A A A + + + + A A A A + + A A + +
Intestine Large, Colon + + A + + A + + + A + + + + + A A A A + + A A + +
Intestine Large, Rectum + + A + + + + + + A + + + + + A A A A + + A A + +
Intestine Small, Duodenum + + A + A A A A A A A + A + + A A A A + + A A + +
Intestine Small, Ileum + + A + + A + A + A A + + + + A A A A + + A A + +
Intestine Small, Jejunum + + A + + A A A A A A + + + + A A A A + + A A + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatoblastoma X X X XHepatoblastoma, Multiple X XHepatocellular Adenoma X X X X X X XHepatocellular Adenoma, Multiple X X X X X X X X X XHepatocellular Carcinoma X X X X X X X XHepatocellular Carcinoma, Multiple X X X X X X XHepatocholangiocarcinoma X
Mesentery
Pancreas + + A + + + + + + + + + + + + + + + + + + + A + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 26
DAY ON TEST
B6C3F1 MICE MALE
0456
0470
0496
0519
0524
0526
0548
0551
0556
0560
0569
0627
0628
0631
0659
0661
0670
0685
0694
0700
0704
0707
0715
0730
0730
625 mg/lANIMAL ID
00108
00124
00137
00131
00123
00149
00104
00101
00115
00114
00106
00148
00122
00145
00139
00127
00133
00150
00105
00118
00144
00132
00129
00113
00117
males(cont...)
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + A + + + + + + A + + + + + + + + + + + + A + +Squamous Cell Carcinoma
Stomach, Glandular + + A + A + A + + A + + + + + A + + A + + + A + +
Tooth + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaHepatocellular Carcinoma, Metastatic, Liver XSubcapsular, Adenoma X X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X
Islets, Pancreatic + + A + + + + + + + + + + + + + + + + + + + A + +Adenoma X
Parathyroid Gland + + M + + + + + + + + M + + + + M + + M + + + + +
Pituitary Gland + + A + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 27
DAY ON TEST
B6C3F1 MICE MALE
0456
0470
0496
0519
0524
0526
0548
0551
0556
0560
0569
0627
0628
0631
0659
0661
0670
0685
0694
0700
0704
0707
0715
0730
0730
625 mg/lANIMAL ID
00108
00124
00137
00131
00123
00149
00104
00101
00115
00114
00106
00148
00122
00145
00139
00127
00133
00150
00105
00118
00144
00132
00129
00113
00117
males(cont...)
Thyroid Gland + + A + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + A + + + + + A + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + A + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Interstitial Cell, Adenoma
HEMATOPOIETIC SYSTEM
Bone Marrow + + A + + + + + + A + + + + + + + + + + + + + + +
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + A + +
Lymph Node, Mesenteric + + A + + + + + + A + + + + + A A + A + + + A + +
Spleen + + A + + + + + + A + + + + + + + + A + + + + + +Hemangiosarcoma
Thymus + + + + + + + + + + + M + + + + + + + + M + + + +Hepatoblastoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 28
DAY ON TEST
B6C3F1 MICE MALE
0456
0470
0496
0519
0524
0526
0548
0551
0556
0560
0569
0627
0628
0631
0659
0661
0670
0685
0694
0700
0704
0707
0715
0730
0730
625 mg/lANIMAL ID
00108
00124
00137
00131
00123
00149
00104
00101
00115
00114
00106
00148
00122
00145
00139
00127
00133
00150
00105
00118
00144
00132
00129
00113
00117
males(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, HemangiosarcomaSubcutaneous Tissue, Lipoma
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +Chondrosarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X X X X XAlveolar/Bronchiolar Adenoma, MultipleAlveolar/Bronchiolar Carcinoma X XHepatoblastoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver X X X X X XHepatocholangiocarcinoma, Metastatic, Liver X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + A + + + + + + A + + A + + A + + + + + + A + +
SPECIAL SENSES SYSTEM
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 29
DAY ON TEST
B6C3F1 MICE MALE
0456
0470
0496
0519
0524
0526
0548
0551
0556
0560
0569
0627
0628
0631
0659
0661
0670
0685
0694
0700
0704
0707
0715
0730
0730
625 mg/lANIMAL ID
00108
00124
00137
00131
00123
00149
00104
00101
00115
00114
00106
00148
00122
00145
00139
00127
00133
00150
00105
00118
00144
00132
00129
00113
00117
males(cont...)
Eye + + A + + A + + + A A + + + + A + + A + + + A + +
Harderian Gland + + + + + + + + + A + + + + + A + + A + + + A + +Adenoma XCarcinoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X XHepatocholangiocarcinoma, Metastatic, Liver XRenal Tubule, Carcinoma
Urethra + + + + +
Urinary Bladder + + A + + + + + + A + + + + + A + + A + + + A + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 30
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
625 mg/lANIMAL ID
00120
00147
00102
00110
00112
00119
00121
00125
00126
00128
00135
00136
00138
00142
00103
00107
00109
00111
00116
00130
00134
00140
00141
00143
00146 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 39
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 41
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 42
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 35
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 39
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 37
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X X 3Hepatoblastoma X X X X X 9Hepatoblastoma, Multiple 2Hepatocellular Adenoma X X X X 11Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X X X 29Hepatocellular Carcinoma X X X X X X X X X 17Hepatocellular Carcinoma, Multiple X X 9Hepatocholangiocarcinoma 1
Mesentery + 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 48
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 31
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
625 mg/lANIMAL ID
00120
00147
00102
00110
00112
00119
00121
00125
00126
00128
00135
00136
00138
00142
00103
00107
00109
00111
00116
00130
00134
00140
00141
00143
00146 * TOTALS
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 47Squamous Cell Carcinoma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 43
Tooth + + + + + + + + + + + + + + + + + + + + + + + 42
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Carcinoma, Metastatic, Liver 2
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Hepatocellular Carcinoma, Metastatic, Liver 1Subcapsular, Adenoma X X 5
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Carcinoma, Metastatic, Liver 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 48Adenoma 1
Parathyroid Gland + + + + + + + M + + + + + + + + + + M + + + + + + 44
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Pars Distalis, Adenoma X 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 32
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
625 mg/lANIMAL ID
00120
00147
00102
00110
00112
00119
00121
00125
00126
00128
00135
00136
00138
00142
00103
00107
00109
00111
00116
00130
00134
00140
00141
00143
00146 * TOTALS
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 48
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 49
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Interstitial Cell, Adenoma X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 48
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 49
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + M + + + 43
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 47Hemangiosarcoma X X 2
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 48Hepatoblastoma, Metastatic, Liver 1Hepatocellular Carcinoma, Metastatic, Liver 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 33
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
625 mg/lANIMAL ID
00120
00147
00102
00110
00112
00119
00121
00125
00126
00128
00135
00136
00138
00142
00103
00107
00109
00111
00116
00130
00134
00140
00141
00143
00146 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Hemangiosarcoma X X 2Subcutaneous Tissue, Lipoma X 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Chondrosarcoma 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X X 14Alveolar/Bronchiolar Adenoma, Multiple X X 2Alveolar/Bronchiolar Carcinoma X X X X X X 8Hepatoblastoma, Metastatic, Liver 1Hepatocellular Carcinoma, Metastatic, Liver X X X X X X 12Hepatocholangiocarcinoma, Metastatic, Liver 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 45
SPECIAL SENSES SYSTEM
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 34
DAY ON TEST
B6C3F1 MICE MALE
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
625 mg/lANIMAL ID
00120
00147
00102
00110
00112
00119
00121
00125
00126
00128
00135
00136
00138
00142
00103
00107
00109
00111
00116
00130
00134
00140
00141
00143
00146 * TOTALS
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 43
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 46Adenoma X X 3Carcinoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Carcinoma, Metastatic, Liver 2Hepatocholangiocarcinoma, Metastatic, Liver 1Renal Tubule, Carcinoma X 1
Urethra 5
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 45
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant 2
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 35
DAY ON TEST
B6C3F1 MICE MALE
0399
0425
0465
0522
0534
0534
0534
0571
0675
0687
0690
0709
0710
0713
0715
0717
0724
0730
0730
0730
0730
0730
0730
0730
0730
1250 mg/lANIMAL ID
00188
00185
00155
00165
00153
00163
00194
00175
00161
00164
00174
00168
00170
00177
00160
00196
00178
00151
00158
00159
00179
00180
00181
00186
00190
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder A A + A + + + A A A + A + + M + + + + + + + + + +
Intestine Large, Cecum A A + A + + + A A A A A + A A + + + + + + + + + +
Intestine Large, Colon A A + A + + + A A A A A + A A + + + + + + + + + +
Intestine Large, Rectum A A + + + + + A A A A A + A A + + + + + + + + + +
Intestine Small, Duodenum A A + A + + + A A A A A + A A + + + + + + + + + +Adenoma
Intestine Small, Ileum A A + A + + + A A A A A + A A + + + + + + + + + +
Intestine Small, Jejunum A A + A + + + A A A A A + A A + + + + + + + + + +Adenoma
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Cholangioma, Multiple XHemangiosarcoma XHepatoblastoma X X XHepatocellular Adenoma X X X X X X X XHepatocellular Adenoma, Multiple X X X X X X X XHepatocellular Carcinoma X X X X X X X XHepatocellular Carcinoma, Multiple X X X X
Mesentery +
Pancreas + + + + + + + + + A + + + + + + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 36
DAY ON TEST
B6C3F1 MICE MALE
0399
0425
0465
0522
0534
0534
0534
0571
0675
0687
0690
0709
0710
0713
0715
0717
0724
0730
0730
0730
0730
0730
0730
0730
0730
1250 mg/lANIMAL ID
00188
00185
00155
00165
00153
00163
00194
00175
00161
00164
00174
00168
00170
00177
00160
00196
00178
00151
00158
00159
00179
00180
00181
00186
00190
males(cont...)
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach A + + + + + + + + A A + + + + + + + + + + + + + +Squamous Cell Papilloma X
Stomach, Glandular A + + + + + + A + A A + + + A + + + + + + + + + +
Tooth + + + + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + A A + + + + + + + + + +Subcapsular, Adenoma X X
Adrenal Medulla + + + + + + + + + + + + + A A + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + A + + + + + + + + + + + + + + +
Parathyroid Gland M + M + + M + + + M M M M M + + + M + + + + + M +
Pituitary Gland + + + + + + + + + M + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + A + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 37
DAY ON TEST
B6C3F1 MICE MALE
0399
0425
0465
0522
0534
0534
0534
0571
0675
0687
0690
0709
0710
0713
0715
0717
0724
0730
0730
0730
0730
0730
0730
0730
0730
1250 mg/lANIMAL ID
00188
00185
00155
00165
00153
00163
00194
00175
00161
00164
00174
00168
00170
00177
00160
00196
00178
00151
00158
00159
00179
00180
00181
00186
00190
males(cont...)
Epididymis + + + + + + + + + A + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + A + + + + + + + A + A + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +Interstitial Cell, Adenoma X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X
Lymph Node +Mediastinal, HemangiosarcomaMediastinal, Hepatocellular Carcinoma,
Metastatic, LiverX
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X
Lymph Node, Mesenteric + + + + + + + + + M A A + + A + + + + + + + + + +
Spleen A + + + + + + + + A + + + A A + + + + + + + + + +Hemangiosarcoma X
Thymus + + + + + + + + + + M + + + A + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 38
DAY ON TEST
B6C3F1 MICE MALE
0399
0425
0465
0522
0534
0534
0534
0571
0675
0687
0690
0709
0710
0713
0715
0717
0724
0730
0730
0730
0730
0730
0730
0730
0730
1250 mg/lANIMAL ID
00188
00185
00155
00165
00153
00163
00194
00175
00161
00164
00174
00168
00170
00177
00160
00196
00178
00151
00158
00159
00179
00180
00181
00186
00190
males(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrous HistiocytomaSubcutaneous Tissue, HemangiomaSubcutaneous Tissue, HemangiosarcomaSubcutaneous Tissue, Lipoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X XAlveolar/Bronchiolar Adenoma, Multiple XAlveolar/Bronchiolar Carcinoma XAlveolar/Bronchiolar Carcinoma, Multiple XCarcinoma, Metastatic, Harderian Gland XHepatocellular Carcinoma, Metastatic, Liver X X X X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Harderian Gland X
Pleura +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 39
DAY ON TEST
B6C3F1 MICE MALE
0399
0425
0465
0522
0534
0534
0534
0571
0675
0687
0690
0709
0710
0713
0715
0717
0724
0730
0730
0730
0730
0730
0730
0730
0730
1250 mg/lANIMAL ID
00188
00185
00155
00165
00153
00163
00194
00175
00161
00164
00174
00168
00170
00177
00160
00196
00178
00151
00158
00159
00179
00180
00181
00186
00190
males(cont...)
Hepatocellular Carcinoma, Metastatic, Liver X
Trachea + + + + + + + + + + + + + + A + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye A A + A + + + A A A A A + A A + + + + + + + + + +
Harderian Gland + + + + + + + + + A A + + A + + + + + + + + + + +Adenoma X XCarcinoma X X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + A + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver X XRenal Tubule, Adenoma, Multiple
Urethra + + +
Urinary Bladder A + + + + + + + + A + A + + A + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 40
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
1250 mg/lANIMAL ID
00191
00157
00162
00166
00169
00172
00183
00187
00189
00192
00199
00200
00152
00154
00156
00167
00171
00173
00176
00182
00184
00193
00195
00197
00198 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 42
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 40
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 40
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 41
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 40Adenoma X 1
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 40
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 40Adenoma X 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Cholangioma, Multiple 1Hemangiosarcoma 1Hepatoblastoma X 4Hepatocellular Adenoma X X X X X X X 15Hepatocellular Adenoma, Multiple X X X X X X X X X X X X 20Hepatocellular Carcinoma X X X X X X X 15Hepatocellular Carcinoma, Multiple X X X X 8
Mesentery 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 49
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 41
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
1250 mg/lANIMAL ID
00191
00157
00162
00166
00169
00172
00183
00187
00189
00192
00199
00200
00152
00154
00156
00167
00171
00173
00176
00182
00184
00193
00195
00197
00198 * TOTALS
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 47Squamous Cell Papilloma X X 3
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 45
Tooth + + + + + + + + + + + + + + + + + + + + + + 41
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 48Subcapsular, Adenoma X 3
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 48
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 49
Parathyroid Gland + + M M + + + M + M + + + + M + + M + + M M M + + 31
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 42
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
1250 mg/lANIMAL ID
00191
00157
00162
00166
00169
00172
00183
00187
00189
00192
00199
00200
00152
00154
00156
00167
00171
00173
00176
00182
00184
00193
00195
00197
00198 * TOTALS
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 49
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 47
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Interstitial Cell, Adenoma 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 2
Lymph Node + 2Mediastinal, Hemangiosarcoma X 1Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Carcinoma, Metastatic, Liver 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + M + + 45
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 46Hemangiosarcoma X 2
Thymus + + + + + M + + + + + + + + + + + + + + + + + + + 47Hepatocellular Carcinoma, Metastatic, Liver 2
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 43
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
1250 mg/lANIMAL ID
00191
00157
00162
00166
00169
00172
00183
00187
00189
00192
00199
00200
00152
00154
00156
00167
00171
00173
00176
00182
00184
00193
00195
00197
00198 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrous Histiocytoma X 1Subcutaneous Tissue, Hemangioma X 1Subcutaneous Tissue, Hemangiosarcoma X 1Subcutaneous Tissue, Lipoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X 6Alveolar/Bronchiolar Adenoma, Multiple X 2Alveolar/Bronchiolar Carcinoma X X X X X 6Alveolar/Bronchiolar Carcinoma, Multiple X X 3Carcinoma, Metastatic, Harderian Gland 1Hepatocellular Carcinoma, Metastatic, Liver X X 6
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma, Metastatic, Harderian Gland 1
Pleura 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 44
DAY ON TEST
B6C3F1 MICE MALE
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
1250 mg/lANIMAL ID
00191
00157
00162
00166
00169
00172
00183
00187
00189
00192
00199
00200
00152
00154
00156
00167
00171
00173
00176
00182
00184
00193
00195
00197
00198 * TOTALS
Hepatocellular Carcinoma, Metastatic, Liver 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 49
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 40
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47Adenoma 2Carcinoma X 3
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 49Hepatocellular Carcinoma, Metastatic, Liver 2Renal Tubule, Adenoma, Multiple X 1
Urethra 3
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 46
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50
*** END OF MALE DATA ***
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 45
DAY ON TEST
B6C3F1 MICE FEMALE
0347
0372
0598
0639
0643
0668
0669
0674
0680
0682
0698
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 mg/lANIMAL ID
00214
00203
00245
00246
00226
00219
00223
00206
00204
00227
00207
00212
00205
00209
00216
00220
00225
00229
00230
00232
00234
00236
00240
00243
00247
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder A A + A A + + A + A + A + + + + + + + + + + + + +
Intestine Large, Cecum A A + A A + + A + A + + + + + + + + + + + + + + +
Intestine Large, Colon A A + A A + + A + A + + + + + + + + + + + + + + +
Intestine Large, Rectum A A + A A + + A + A + A + + + + + + + + + + + + +
Intestine Small, Duodenum A A + A A + + A + A A A + + + + + + + + + + + + +
Intestine Small, Ileum A A + A A + + A + A + + + + + + + + + + + + + + +
Intestine Small, Jejunum A A + A A + + A + A + A + + + + + + + + + + + + +
Liver + A + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatoblastoma XHepatocellular Adenoma X X X X X X XHepatocellular Adenoma, Multiple X X X X X X X X X X X XHepatocellular Carcinoma X X XHepatocellular Carcinoma, Multiple X X X X
Mesentery + + + + + +
Pancreas A A + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 46
DAY ON TEST
B6C3F1 MICE FEMALE
0347
0372
0598
0639
0643
0668
0669
0674
0680
0682
0698
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 mg/lANIMAL ID
00214
00203
00245
00246
00226
00219
00223
00206
00204
00227
00207
00212
00205
00209
00216
00220
00225
00229
00230
00232
00234
00236
00240
00243
00247
females(cont...)
Stomach, Forestomach + A + + + + + A + A + + + + + + + + + + + + + + +
Stomach, Glandular A A + + A + + A + A + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Blood Vessel + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + A + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + A + + + + + + + + + + + + + + + + + + + + + + +Pheochromocytoma Benign
Islets, Pancreatic A A + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + A + M + + + + + + + + + + + M + + + M + + M M +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X X X
Thyroid Gland A A + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 47
DAY ON TEST
B6C3F1 MICE FEMALE
0347
0372
0598
0639
0643
0668
0669
0674
0680
0682
0698
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 mg/lANIMAL ID
00214
00203
00245
00246
00226
00219
00223
00206
00204
00227
00207
00212
00205
00209
00216
00220
00225
00229
00230
00232
00234
00236
00240
00243
00247
females(cont...)
Ovary + A + + + + + + + + + + + + + + + + + + + + + + +Cystadenoma
Uterus + A + + + + + + + + + + + + + + + + + + + + + + +Polyp Stromal XEndometrium, Adenoma X
HEMATOPOIETIC SYSTEM
Bone Marrow + A + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma
Lymph Node + + +
Lymph Node, Mandibular + A + + + + + A + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + A + A A + + A + + + + + + + + + + + + + + + + +
Spleen A A + A A + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma
Thymus + A M A + + + A + + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Mast Cell Tumor BenignSubcutaneous Tissue, HemangiosarcomaSubcutaneous Tissue, Sarcoma X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 48
DAY ON TEST
B6C3F1 MICE FEMALE
0347
0372
0598
0639
0643
0668
0669
0674
0680
0682
0698
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 mg/lANIMAL ID
00214
00203
00245
00246
00226
00219
00223
00206
00204
00227
00207
00212
00205
00209
00216
00220
00225
00229
00230
00232
00234
00236
00240
00243
00247
females(cont...)
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +Osteosarcoma X
Skeletal Muscle +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
Peripheral Nerve +
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X XAlveolar/Bronchiolar Carcinoma X X X XCarcinoma, Metastatic, Harderian Gland XHepatocellular Carcinoma, Metastatic, Liver XSarcoma, Metastatic, Skin X
Nose + A + + + + + + + + + + + + + + + + + + + + + + +
Trachea A A + + A + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye A A + + A + + A + A A A + + + + + + + + + + + + +Carcinoma, Metastatic, Harderian Gland X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 49
DAY ON TEST
B6C3F1 MICE FEMALE
0347
0372
0598
0639
0643
0668
0669
0674
0680
0682
0698
0726
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 mg/lANIMAL ID
00214
00203
00245
00246
00226
00219
00223
00206
00204
00227
00207
00212
00205
00209
00216
00220
00225
00229
00230
00232
00234
00236
00240
00243
00247
females(cont...)
Harderian Gland A A + A + + + A + A + + + + + + + + + + + + + + +Adenoma XCarcinoma X X
URINARY SYSTEM
Kidney + A + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder A A + A A + + A + A + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 50
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0 mg/lANIMAL ID
00250
00210
00215
00217
00221
00222
00233
00235
00239
00241
00249
00201
00202
00208
00211
00213
00218
00224
00228
00231
00237
00238
00242
00244
00248 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 43
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 44
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 44
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 43
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 42
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 44
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 43
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 2Hepatoblastoma 1Hepatocellular Adenoma X X X X 11Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X 27Hepatocellular Carcinoma X X X 6Hepatocellular Carcinoma, Multiple X 5
Mesentery + + 8
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 48
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 51
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0 mg/lANIMAL ID
00250
00210
00215
00217
00221
00222
00233
00235
00239
00241
00249
00201
00202
00208
00211
00213
00218
00224
00228
00231
00237
00238
00242
00244
00248 * TOTALS
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 47
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 45
CARDIOVASCULAR SYSTEM
Blood Vessel 2
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 49
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 49Pheochromocytoma Benign X 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 48
Parathyroid Gland + + M + M + + M + + + M + + + + + + + M + + M + + 38
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Adenoma X 4
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 52
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0 mg/lANIMAL ID
00250
00210
00215
00217
00221
00222
00233
00235
00239
00241
00249
00201
00202
00208
00211
00213
00218
00224
00228
00231
00237
00238
00242
00244
00248 * TOTALS
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 49Cystadenoma X X X 3
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 49Polyp Stromal X 2Endometrium, Adenoma 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 1
Lymph Node + + + 6
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 48
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 46
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 46Hemangiosarcoma X 1
Thymus + + + + + + + + + M + + + + + + + + + + + + + + + 45
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Mast Cell Tumor Benign X 1Subcutaneous Tissue, Hemangiosarcoma X X 2Subcutaneous Tissue, Sarcoma 2
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 53
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0 mg/lANIMAL ID
00250
00210
00215
00217
00221
00222
00233
00235
00239
00241
00249
00201
00202
00208
00211
00213
00218
00224
00228
00231
00237
00238
00242
00244
00248 * TOTALS
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Osteosarcoma X 2
Skeletal Muscle 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
Peripheral Nerve 1
Spinal Cord 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X 5Alveolar/Bronchiolar Carcinoma X X X 7Carcinoma, Metastatic, Harderian Gland 1Hepatocellular Carcinoma, Metastatic, Liver 1Sarcoma, Metastatic, Skin 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 47
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 43Carcinoma, Metastatic, Harderian Gland 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 54
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0 mg/lANIMAL ID
00250
00210
00215
00217
00221
00222
00233
00235
00239
00241
00249
00201
00202
00208
00211
00213
00218
00224
00228
00231
00237
00238
00242
00244
00248 * TOTALS
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 45Adenoma X 2Carcinoma 2
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 49
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 44
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Lymphoma Malignant X X X X X X X X X 14
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 55
DAY ON TEST
B6C3F1 MICE FEMALE
0382
0494
0508
0533
0553
0588
0628
0662
0672
0680
0685
0697
0700
0704
0711
0711
0718
0724
0729
0729
0729
0729
0729
0729
0729
312.5 mg/lANIMAL ID
00279
00276
00255
00294
00265
00253
00281
00299
00282
00268
00252
00263
00272
00291
00266
00286
00292
00295
00251
00254
00257
00260
00264
00270
00273
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + M + + + + + + + + + +
Gallbladder A A A + A A A A A A A A + A + A + + + + + + + + +Hepatoblastoma, Metastatic, Liver X
Intestine Large, Cecum A A A + A A + A A A A A A A A A + + + + + + + + +
Intestine Large, Colon A A A + A A A A A A A A A A A A + + + + + + + + +
Intestine Large, Rectum A A A + A A A A A A A A A A A A + + + + + + + + +
Intestine Small, Duodenum A A A + A A A A A A A A A A A A + + + + + + + + +
Intestine Small, Ileum A A A + A A + A A A A A A A A A + + + + + + + + +
Intestine Small, Jejunum A A A + A A A A A A A A A A A A + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X XHepatoblastoma X XHepatocellular Adenoma XHepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X X X X XHepatocellular Carcinoma X X X X XHepatocellular Carcinoma, Multiple X X XMast Cell Tumor Malignant X
Mesentery + + + + + + + +
Pancreas A A A + + + + A A A + + + A A + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 56
DAY ON TEST
B6C3F1 MICE FEMALE
0382
0494
0508
0533
0553
0588
0628
0662
0672
0680
0685
0697
0700
0704
0711
0711
0718
0724
0729
0729
0729
0729
0729
0729
0729
312.5 mg/lANIMAL ID
00279
00276
00255
00294
00265
00253
00281
00299
00282
00268
00252
00263
00272
00291
00266
00286
00292
00295
00251
00254
00257
00260
00264
00270
00273
females(cont...)
Salivary Glands + + + + + + + M + M + + + + M + + + + + + + + + +
Stomach, Forestomach A + + + + + A + A + A + + A A A + + + + + + + + +Squamous Cell CarcinomaSquamous Cell Papilloma
Stomach, Glandular A A A + A + A + A A A + + A A A + + + + + + + + +
Tooth + MGingiva, Fibroma, Osseous X
CARDIOVASCULAR SYSTEM
Blood Vessel + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex A + A + + + + A + + + + + A + A + + + + + + + + +
Adrenal Medulla A + A + + + + A + + + + + A + A + + + + + + + + +Pheochromocytoma BenignPheochromocytoma Malignant X
Islets, Pancreatic A A A + + + + A A A + + A A A + + + + + + + + + +Adenoma
Parathyroid Gland M M + M + + + M + M + + + M M + + + + + + + M + M
Pituitary Gland + + + + A + + M + + + + + + M + + + + + + + + + +Pars Distalis, Adenoma X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 57
DAY ON TEST
B6C3F1 MICE FEMALE
0382
0494
0508
0533
0553
0588
0628
0662
0672
0680
0685
0697
0700
0704
0711
0711
0718
0724
0729
0729
0729
0729
0729
0729
0729
312.5 mg/lANIMAL ID
00279
00276
00255
00294
00265
00253
00281
00299
00282
00268
00252
00263
00272
00291
00266
00286
00292
00295
00251
00254
00257
00260
00264
00270
00273
females(cont...)
Thyroid Gland M + + + + + + M A M + + + + M + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary A + A + + + + + + + + + + + + + + + + + + + + + +Cystadenoma X
Uterus A + A + A + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow A A A + + + + A + + + + + + + + + + + + + + + + +Mast Cell Tumor Malignant X
Lymph Node + + + + + +Iliac, Mast Cell Tumor Malignant XLumbar, Hemangiosarcoma XRenal, Hemangiosarcoma X
Lymph Node, Mandibular + A + + + + + M + A A + A + M A + + + + + + + + +
Lymph Node, Mesenteric A A A + A + + + A A A A A A A A + + + + + + + + +
Spleen A A A + + + A + + A + A + A A + + + + + + + + + +Hemangiosarcoma XMast Cell Tumor Malignant X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 58
DAY ON TEST
B6C3F1 MICE FEMALE
0382
0494
0508
0533
0553
0588
0628
0662
0672
0680
0685
0697
0700
0704
0711
0711
0718
0724
0729
0729
0729
0729
0729
0729
0729
312.5 mg/lANIMAL ID
00279
00276
00255
00294
00265
00253
00281
00299
00282
00268
00252
00263
00272
00291
00266
00286
00292
00295
00251
00254
00257
00260
00264
00270
00273
females(cont...)
Thymus + + A + + + + A M A + + + + M + + + + + + + + + +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + A + + + + + + + + + + + +Carcinoma X
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrous HistiocytomaSubcutaneous Tissue, Hemangiosarcoma XSubcutaneous Tissue, Sarcoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain A + + + + + + M + + + + + + M + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar AdenomaAlveolar/Bronchiolar Adenoma, Multiple XAlveolar/Bronchiolar Carcinoma X XAlveolar/Bronchiolar Carcinoma, Multiple XHepatocellular Carcinoma, Metastatic, Liver XMast Cell Tumor Malignant X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 59
DAY ON TEST
B6C3F1 MICE FEMALE
0382
0494
0508
0533
0553
0588
0628
0662
0672
0680
0685
0697
0700
0704
0711
0711
0718
0724
0729
0729
0729
0729
0729
0729
0729
312.5 mg/lANIMAL ID
00279
00276
00255
00294
00265
00253
00281
00299
00282
00268
00252
00263
00272
00291
00266
00286
00292
00295
00251
00254
00257
00260
00264
00270
00273
females(cont...)
Nose A A A + + + + M + + + + + A M + + + + + + + + + +
Trachea A A + + + A + M + A + + A A M A + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye A A A + A A A M A A A A A A M A + + + + + + + + +
Harderian Gland + A A + + + + M + A A + A A M A + + + + + + + + +CarcinomaBilateral, Carcinoma
URINARY SYSTEM
Kidney + A A + + + + + + + + + + A + + + + + + + + + + +Mast Cell Tumor Malignant X
Urinary Bladder + A A + A A + A A A A A A A A A + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X X X X X X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 60
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
312.5 mg/lANIMAL ID
00274
00283
00287
00298
00256
00258
00259
00261
00262
00269
00271
00275
00277
00280
00284
00285
00288
00289
00290
00296
00297
00267
00278
00293
00300 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 49
Gallbladder M + + + + + + + + + + + + + + + + + + + + + + + + 36Hepatoblastoma, Metastatic, Liver 1
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 35
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 35
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 35
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 35
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X X X 5Hepatoblastoma X 3Hepatocellular Adenoma X X 3Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X X X X X X 43Hepatocellular Carcinoma X X X X X X X X 13Hepatocellular Carcinoma, Multiple X X X X 7Mast Cell Tumor Malignant 1
Mesentery + + + + + + + + 16
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 42
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 61
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
312.5 mg/lANIMAL ID
00274
00283
00287
00298
00256
00258
00259
00261
00262
00269
00271
00275
00277
00280
00284
00285
00288
00289
00290
00296
00297
00267
00278
00293
00300 * TOTALS
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 47
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 43Squamous Cell Carcinoma X 1Squamous Cell Papilloma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 39
Tooth 1Gingiva, Fibroma, Osseous 1
CARDIOVASCULAR SYSTEM
Blood Vessel 3
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 45
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 45Pheochromocytoma Benign X 1Pheochromocytoma Malignant X 2
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 41Adenoma X 1
Parathyroid Gland M + + + + + + + M + + + + + + M + M M + + + M M + 34
Pituitary Gland + + + + + + + + + + + M + + + + + + + + + + + + + 46Pars Distalis, Adenoma X X X X 5
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 62
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
312.5 mg/lANIMAL ID
00274
00283
00287
00298
00256
00258
00259
00261
00262
00269
00271
00275
00277
00280
00284
00285
00288
00289
00290
00296
00297
00267
00278
00293
00300 * TOTALS
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 45
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 48Cystadenoma X X X 4
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 47
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 46Mast Cell Tumor Malignant 1
Lymph Node + + 8Iliac, Mast Cell Tumor Malignant 1Lumbar, Hemangiosarcoma 1Renal, Hemangiosarcoma 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + M + + 42
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 38
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 42Hemangiosarcoma X 2Mast Cell Tumor Malignant 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 63
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
312.5 mg/lANIMAL ID
00274
00283
00287
00298
00256
00258
00259
00261
00262
00269
00271
00275
00277
00280
00284
00285
00288
00289
00290
00296
00297
00267
00278
00293
00300 * TOTALS
Thymus + + + + + + + + + + + + + + + + + M + + + + + + + 44Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Carcinoma 1
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrous Histiocytoma X 1Subcutaneous Tissue, Hemangiosarcoma 1Subcutaneous Tissue, Sarcoma X 2
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 47
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X 5Alveolar/Bronchiolar Adenoma, Multiple 1Alveolar/Bronchiolar Carcinoma X X X X 6Alveolar/Bronchiolar Carcinoma, Multiple X 2Hepatocellular Carcinoma, Metastatic, Liver X X X X 5Mast Cell Tumor Malignant 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 64
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
312.5 mg/lANIMAL ID
00274
00283
00287
00298
00256
00258
00259
00261
00262
00269
00271
00275
00277
00280
00284
00285
00288
00289
00290
00296
00297
00267
00278
00293
00300 * TOTALS
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 44
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 41
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 35
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 41Carcinoma X 1Bilateral, Carcinoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 47Mast Cell Tumor Malignant 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 37
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X X X X X X 15
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 65
DAY ON TEST
B6C3F1 MICE FEMALE
0309
0522
0549
0617
0620
0643
0647
0648
0669
0686
0704
0704
0711
0712
0717
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
625 mg/lANIMAL ID
00314
00336
00329
00343
00328
00322
00323
00327
00349
00348
00303
00304
00345
00321
00347
00301
00306
00308
00309
00312
00316
00318
00319
00326
00333
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + M + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + A A A A A A A A A A + A A A + + A + + + + + + +
Intestine Large, Cecum + A A A A A + A A A A + A A + + + A + + + + + + +Carcinoma
Intestine Large, Colon + A A A + + + A A A A + A A A + + + + + + + + + +
Intestine Large, Rectum + A A A A A + A A A A + A A A + + A + + + + + + +
Intestine Small, Duodenum + A A A A A + A A A A A A A A + + A + + + + + + +
Intestine Small, Ileum + A A A A A + A A A A + A A A + + A + + + + + + +
Intestine Small, Jejunum + A A A A A + A A A A + A A A + + A + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +HemangiosarcomaHepatoblastoma XHepatoblastoma, Multiple XHepatocellular Adenoma X X X X X X XHepatocellular Adenoma, Multiple X X X X X X X X X X X X X XHepatocellular Carcinoma X X X X X X X XHepatocellular Carcinoma, Multiple X X X X XRhabdomyosarcoma, Metastatic, Uncertain
Primary SiteX
Mesentery + + + + + + +Lipoma X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 66
DAY ON TEST
B6C3F1 MICE FEMALE
0309
0522
0549
0617
0620
0643
0647
0648
0669
0686
0704
0704
0711
0712
0717
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
625 mg/lANIMAL ID
00314
00336
00329
00343
00328
00322
00323
00327
00349
00348
00303
00304
00345
00321
00347
00301
00306
00308
00309
00312
00316
00318
00319
00326
00333
females(cont...)
Rhabdomyosarcoma, Metastatic, UncertainPrimary Site
X
Pancreas + A A + + A + A + + + + + + + + + + + + + + + + +Rhabdomyosarcoma, Metastatic, Uncertain
Primary SiteX
Salivary Glands + + M M + + + + + + + + M + + + + + + + + + + + +
Stomach, Forestomach + + A A + A + + A + + + + + + + + A + + + + + + +Squamous Cell Papilloma
Stomach, Glandular + + A A + A + A A A A + + A + + + A + + + + + + +
Tooth M
CARDIOVASCULAR SYSTEM
Blood Vessel +
Heart + + M + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + A A + + + A + + + + A + + + + + + + + + + + +
Adrenal Medulla + + A A + + + A + + + + A + + + + + + + + + + + +Pheochromocytoma Complex X
Islets, Pancreatic + A A A + A + A + + + + + + + + + + + + + + + + +
Parathyroid Gland M + M M + + + + M + + + M + + + M + + + + + + + +
Pituitary Gland + + M + + A + + + + + + M + + + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 67
DAY ON TEST
B6C3F1 MICE FEMALE
0309
0522
0549
0617
0620
0643
0647
0648
0669
0686
0704
0704
0711
0712
0717
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
625 mg/lANIMAL ID
00314
00336
00329
00343
00328
00322
00323
00327
00349
00348
00303
00304
00345
00321
00347
00301
00306
00308
00309
00312
00316
00318
00319
00326
00333
females(cont...)
Pars Distalis, Adenoma X
Thyroid Gland + + M A + A + A + + + + M + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + I + + + + + + + + + + M + + + + + + + + + + +
Ovary + + A A + + + + + + + + + + + + + + + + + + + + +
Uterus + + A + + + + + + + + + + + + + + + + + + + + + +Cervix, Sarcoma
HEMATOPOIETIC SYSTEM
Bone Marrow + + A + + + + A + + + + + + + + + + + + + + + + +
Lymph Node + + + + +
Lymph Node, Mandibular + + M A + + + + + + + + M + + + + + + + + + + + +
Lymph Node, Mesenteric + A A A + + + A + + + + A + + + + + + + + + + + +
Spleen + + A A + + + A A + + + A + + + + + + + + + + + +
Thymus + + M + + + + + + + + + A + + + + + + + + + + + +HemangiosarcomaRhabdomyosarcoma, Metastatic, Uncertain
Primary SiteX
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 68
DAY ON TEST
B6C3F1 MICE FEMALE
0309
0522
0549
0617
0620
0643
0647
0648
0669
0686
0704
0704
0711
0712
0717
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
625 mg/lANIMAL ID
00314
00336
00329
00343
00328
00322
00323
00327
00349
00348
00303
00304
00345
00321
00347
00301
00306
00308
00309
00312
00316
00318
00319
00326
00333
females(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland + + M + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Rhabdomyosarcoma,
Metastatic, Uncertain Primary SiteX
Subcutaneous Tissue, Sarcoma X X X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + M + + + + A + + + + M + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + M + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X XAlveolar/Bronchiolar Carcinoma X XAlveolar/Bronchiolar Carcinoma, Multiple XCarcinoma, Metastatic, Harderian GlandHepatocellular Carcinoma, Metastatic, Liver X X X X XSarcoma, Metastatic, Skin X
Nose + + M + + + + + + + + + + + + + + + + + + + + + +
Trachea + + M A + + + A + A + + A + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 69
DAY ON TEST
B6C3F1 MICE FEMALE
0309
0522
0549
0617
0620
0643
0647
0648
0669
0686
0704
0704
0711
0712
0717
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
625 mg/lANIMAL ID
00314
00336
00329
00343
00328
00322
00323
00327
00349
00348
00303
00304
00345
00321
00347
00301
00306
00308
00309
00312
00316
00318
00319
00326
00333
females(cont...)
Eye + A M A A A A A A M A + M A M + + A + + + + + + +
Harderian Gland + A M A + + + + A + A + M A + + + + + + + + + + +Adenoma X XCarcinoma
URINARY SYSTEM
Kidney + + A + + + + A + + + + + + + + + + + + + + + + +
Urinary Bladder + A A A A A A A A + A + A + A + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 70
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
625 mg/lANIMAL ID
00338
00339
00307
00310
00315
00320
00325
00332
00334
00340
00342
00344
00346
00350
00302
00305
00311
00313
00317
00324
00330
00331
00335
00337
00341 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 49
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 38Carcinoma X 1
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 40
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 37
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 36
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 37
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 37
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X X X 3Hepatoblastoma X X 3Hepatoblastoma, Multiple 1Hepatocellular Adenoma X X X 10Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X X X X X X 36Hepatocellular Carcinoma X X X X X X X X 16Hepatocellular Carcinoma, Multiple X X X X X 10Rhabdomyosarcoma, Metastatic, Uncertain
Primary Site 1
Mesentery + + + + + + + + + 16Lipoma 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 71
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
625 mg/lANIMAL ID
00338
00339
00307
00310
00315
00320
00325
00332
00334
00340
00342
00344
00346
00350
00302
00305
00311
00313
00317
00324
00330
00331
00335
00337
00341 * TOTALS
Rhabdomyosarcoma, Metastatic, UncertainPrimary Site
1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 46Rhabdomyosarcoma, Metastatic, Uncertain
Primary Site 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 47
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 45Squamous Cell Papilloma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 41
Tooth + + 2
CARDIOVASCULAR SYSTEM
Blood Vessel 1
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 49
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 46
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 46Pheochromocytoma Complex 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 45
Parathyroid Gland + M + + + + + + + M + M + + + + + + + + + M + + + 40
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 72
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
625 mg/lANIMAL ID
00338
00339
00307
00310
00315
00320
00325
00332
00334
00340
00342
00344
00346
00350
00302
00305
00311
00313
00317
00324
00330
00331
00335
00337
00341 * TOTALS
Pars Distalis, Adenoma X 2
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 45
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 48
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 49Cervix, Sarcoma X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 48
Lymph Node + 6
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 47
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 45
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 45
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 48Hemangiosarcoma X 1Rhabdomyosarcoma, Metastatic, Uncertain
Primary Site 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 73
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
625 mg/lANIMAL ID
00338
00339
00307
00310
00315
00320
00325
00332
00334
00340
00342
00344
00346
00350
00302
00305
00311
00313
00317
00324
00330
00331
00335
00337
00341 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Rhabdomyosarcoma,
Metastatic, Uncertain Primary Site 1
Subcutaneous Tissue, Sarcoma X 4
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 47
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 49Alveolar/Bronchiolar Adenoma X 4Alveolar/Bronchiolar Carcinoma X X X X X X 8Alveolar/Bronchiolar Carcinoma, Multiple X 2Carcinoma, Metastatic, Harderian Gland X X X 3Hepatocellular Carcinoma, Metastatic, Liver X X X 8Sarcoma, Metastatic, Skin 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 45
SPECIAL SENSES SYSTEM
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 74
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
625 mg/lANIMAL ID
00338
00339
00307
00310
00315
00320
00325
00332
00334
00340
00342
00344
00346
00350
00302
00305
00311
00313
00317
00324
00330
00331
00335
00337
00341 * TOTALS
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 36
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 43Adenoma 2Carcinoma X X X X 4
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 48
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 39
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Lymphoma Malignant X X X X X 10
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 75
DAY ON TEST
B6C3F1 MICE FEMALE
0494
0509
0533
0573
0582
0586
0612
0632
0641
0647
0648
0664
0669
0677
0716
0721
0722
0729
0729
0729
0729
0729
0729
0729
0729
1250 mg/lANIMAL ID
00396
00398
00366
00394
00367
00400
00359
00368
00397
00369
00375
00384
00357
00365
00355
00373
00360
00351
00352
00353
00354
00358
00362
00363
00374
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder A A + A A A A + A A + A + A A A A + + + + + + + +
Intestine Large, Cecum A A + + A A + + A A + A + A A A A + + + + + + + +
Intestine Large, Colon A A + + A A A + A A + A + A A A A + + + + + + + +
Intestine Large, Rectum A A + + A A A + A A + A + A A A A + + + + + + + +
Intestine Small, Duodenum A A + + A A A A A A + A + A A A A + + + + + + + +
Intestine Small, Ileum A A + + A A A + A A + A + A A A A + + + + + + + +
Intestine Small, Jejunum A A + + A A A A A A + A + + A A A + + + + + + + +Carcinoma X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XHepatoblastoma X XHepatoblastoma, MultipleHepatocellular Adenoma X X X X XHepatocellular Adenoma, Multiple X X X X X X X X X X X X X X XHepatocellular Carcinoma X X X X X X X XHepatocellular Carcinoma, Multiple X X XOsteosarcoma, Metastatic, Bone X
Mesentery + + + + +Sarcoma X
Pancreas + + + + + A + + A A + A + + + + A + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 76
DAY ON TEST
B6C3F1 MICE FEMALE
0494
0509
0533
0573
0582
0586
0612
0632
0641
0647
0648
0664
0669
0677
0716
0721
0722
0729
0729
0729
0729
0729
0729
0729
0729
1250 mg/lANIMAL ID
00396
00398
00366
00394
00367
00400
00359
00368
00397
00369
00375
00384
00357
00365
00355
00373
00360
00351
00352
00353
00354
00358
00362
00363
00374
females(cont...)
Sarcoma, Metastatic, Mesentery X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + A + A + + + + + + + + A + + + + + + + + +Squamous Cell Papilloma X
Stomach, Glandular + + + + A A A + A A + A + + A A A + + + + + + + +
Tongue +Squamous Cell Carcinoma X
Tooth + + + + +
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XPericardium, Alveolar/Bronchiolar Carcinoma,
Metastatic, LungX
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaSarcoma, Metastatic, Mesentery X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + A + + A A + A + + + + A + + + + + + + +Adenoma X
Parathyroid Gland M + M + + + M + + + + M + + + + + + M + + + M + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 77
DAY ON TEST
B6C3F1 MICE FEMALE
0494
0509
0533
0573
0582
0586
0612
0632
0641
0647
0648
0664
0669
0677
0716
0721
0722
0729
0729
0729
0729
0729
0729
0729
0729
1250 mg/lANIMAL ID
00396
00398
00366
00394
00367
00400
00359
00368
00397
00369
00375
00384
00357
00365
00355
00373
00360
00351
00352
00353
00354
00358
00362
00363
00374
females(cont...)
Pituitary Gland + + + + + + + + A + + + + + + + + + + + + + + + +Pars Distalis, Adenoma
Thyroid Gland + + + + + + + + + + + + + + A + + + + + + + + + +Follicular Cell, Adenoma
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary + + + + A A + + + + + + + + + + M + + + + + + + +Cystadenoma X X XHemangioma X
Uterus + + + + + + + + A + + + + + + + + + + + + + + + +Hemangiosarcoma
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + A + + + + + + + + + + + + + + + + + + +
Lymph Node + + + + +Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, LungX
Iliac, Sarcoma, Metastatic, Mesentery XMediastinal, Sarcoma, Metastatic, Mesentery X
Lymph Node, Mandibular + + + + + A + + + + + A + + M + + + + + + + + + +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 78
DAY ON TEST
B6C3F1 MICE FEMALE
0494
0509
0533
0573
0582
0586
0612
0632
0641
0647
0648
0664
0669
0677
0716
0721
0722
0729
0729
0729
0729
0729
0729
0729
0729
1250 mg/lANIMAL ID
00396
00398
00366
00394
00367
00400
00359
00368
00397
00369
00375
00384
00357
00365
00355
00373
00360
00351
00352
00353
00354
00358
00362
00363
00374
females(cont...)
Sarcoma, Metastatic, Mesentery X
Lymph Node, Mesenteric A + + + + A + + + + + A + + + + A + + + + + + + +Sarcoma, Metastatic, Mesentery X
Spleen A + + + + A + + A + + A + + + + + + + + + + + + +Fibrosarcoma X
Thymus + + + + + A + + + + + A + + A + + + + + + + + + +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX X
Sarcoma, Metastatic, Mesentery X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + A + + + + + + + + + + A + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Sarcoma X X X X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +Osteosarcoma, Multiple X
Skeletal Muscle +Sarcoma, Metastatic, Mesentery X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
Peripheral Nerve +
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 79
DAY ON TEST
B6C3F1 MICE FEMALE
0494
0509
0533
0573
0582
0586
0612
0632
0641
0647
0648
0664
0669
0677
0716
0721
0722
0729
0729
0729
0729
0729
0729
0729
0729
1250 mg/lANIMAL ID
00396
00398
00366
00394
00367
00400
00359
00368
00397
00369
00375
00384
00357
00365
00355
00373
00360
00351
00352
00353
00354
00358
00362
00363
00374
females(cont...)
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X X X XAlveolar/Bronchiolar Adenoma, MultipleAlveolar/Bronchiolar Carcinoma X X X X XAlveolar/Bronchiolar Carcinoma, Multiple XHepatoblastoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver X XOsteosarcoma, Metastatic, Bone XSarcoma, Metastatic, Mesentery X
Nose + + + + + A + + + + + + + + + A A + + + + + + + +
Pleura +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
Trachea A + + + + A + + + + + A + + A A A + + + + + + + +
SPECIAL SENSES SYSTEM
Eye A A + + A A A + A A + + + A M A A + + + + + + + +
Harderian Gland A + + + A + + + + A + + + + + + + + + + + + + + +Adenoma X XCarcinoma X
Zymbal's Gland
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 80
DAY ON TEST
B6C3F1 MICE FEMALE
0494
0509
0533
0573
0582
0586
0612
0632
0641
0647
0648
0664
0669
0677
0716
0721
0722
0729
0729
0729
0729
0729
0729
0729
0729
1250 mg/lANIMAL ID
00396
00398
00366
00394
00367
00400
00359
00368
00397
00369
00375
00384
00357
00365
00355
00373
00360
00351
00352
00353
00354
00358
00362
00363
00374
females(cont...)
URINARY SYSTEM
Kidney + + + + + + + + + + + A + + + + + + + + + + + + +Alveolar/Bronchiolar Carcinoma, Metastatic,
LungX
Osteosarcoma, Metastatic, Bone XRenal Tubule, Adenoma X
Urinary Bladder + + + + A A A + A + + A + + A + A + + + + + M + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X X X X X
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 81
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
1250 mg/lANIMAL ID
00376
00380
00385
00386
00387
00388
00361
00364
00370
00371
00383
00390
00391
00392
00393
00395
00399
00356
00372
00377
00378
00379
00381
00382
00389 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + M + + + + M + + + + + + 35
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 39
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 38
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 38
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 37
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + M 37
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 38Carcinoma X 2
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 2Hepatoblastoma X 3Hepatoblastoma, Multiple X 1Hepatocellular Adenoma X X X X 9Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X 30Hepatocellular Carcinoma X X X X X X X X X X 18Hepatocellular Carcinoma, Multiple X X 5Osteosarcoma, Metastatic, Bone 1
Mesentery + + + + 9Sarcoma 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 45
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 82
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
1250 mg/lANIMAL ID
00376
00380
00385
00386
00387
00388
00361
00364
00370
00371
00383
00390
00391
00392
00393
00395
00399
00356
00372
00377
00378
00379
00381
00382
00389 * TOTALS
Sarcoma, Metastatic, Mesentery 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 47Squamous Cell Papilloma 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 41
Tongue 1Squamous Cell Carcinoma 1
Tooth + + + + 9
CARDIOVASCULAR SYSTEM
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1Pericardium, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Sarcoma, Metastatic, Mesentery 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 45Adenoma 1
Parathyroid Gland + + + + + M + + + + + M + + + M + + + + + + + + + 41
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 83
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
1250 mg/lANIMAL ID
00376
00380
00385
00386
00387
00388
00361
00364
00370
00371
00383
00390
00391
00392
00393
00395
00399
00356
00372
00377
00378
00379
00381
00382
00389 * TOTALS
Pituitary Gland + + + + M + + + + I + + I + + + + + + + + + + + + 46Pars Distalis, Adenoma X X X 3
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Follicular Cell, Adenoma X 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 47Cystadenoma X X X 6Hemangioma 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 49
Lymph Node + + + 8Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1
Iliac, Sarcoma, Metastatic, Mesentery 1Mediastinal, Sarcoma, Metastatic, Mesentery 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 47
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 84
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
1250 mg/lANIMAL ID
00376
00380
00385
00386
00387
00388
00361
00364
00370
00371
00383
00390
00391
00392
00393
00395
00399
00356
00372
00377
00378
00379
00381
00382
00389 * TOTALS
Sarcoma, Metastatic, Mesentery 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 46Sarcoma, Metastatic, Mesentery 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 46Fibrosarcoma 1
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 47Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2
Sarcoma, Metastatic, Mesentery 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 48
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Sarcoma 4
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Osteosarcoma, Multiple 1
Skeletal Muscle 1Sarcoma, Metastatic, Mesentery 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
Peripheral Nerve 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 85
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
1250 mg/lANIMAL ID
00376
00380
00385
00386
00387
00388
00361
00364
00370
00371
00383
00390
00391
00392
00393
00395
00399
00356
00372
00377
00378
00379
00381
00382
00389 * TOTALS
Spinal Cord 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X 10Alveolar/Bronchiolar Adenoma, Multiple X 1Alveolar/Bronchiolar Carcinoma X X X X 9Alveolar/Bronchiolar Carcinoma, Multiple X X X 4Hepatoblastoma, Metastatic, Liver 1Hepatocellular Carcinoma, Metastatic, Liver X X 4Osteosarcoma, Metastatic, Bone 1Sarcoma, Metastatic, Mesentery 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 47
Pleura 1Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 44
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 39
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47Adenoma 2Carcinoma X X X 4
Zymbal's Gland + 1
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 86
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
1250 mg/lANIMAL ID
00376
00380
00385
00386
00387
00388
00361
00364
00370
00371
00383
00390
00391
00392
00393
00395
00399
00356
00372
00377
00378
00379
00381
00382
00389 * TOTALS
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 49Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1
Osteosarcoma, Metastatic, Bone 1Renal Tubule, Adenoma 1
Urinary Bladder + + + + + M + + + + + + + + + + + + + + + + + + + 41
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Lymphoma Malignant X X X X X X X X 13
*** END OF REPORT ***
TDMS No. 20009 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 05/27/2011Test Type: CHRONIC beta-Picoline Time Report Requested: 09:52:36
Route: DOSED WATER CAS Number: 108-99-6 First Dose M/F: 11/09/04 / 11/08/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 87