nutraceuticals ‘let food be your medicine’. definition other words used in the context: dietary...
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NUTRACEUTICALS
‘Let Food be Your Medicine’
DEFINITION Other words used in the context: Dietary supplementation, Functional,
Multi-functional Foodscoined from “Nutrition” & “Pharmaceutical”
in 1989 by Stephen DeFelice,MD, Founder and Chairman of the Foundation for Innovation in Medicine (FIM).
Nutraceutical can be defined as
“ A food or part of food or nutrient, that provides health benefits, including the prevention and treatment of a disease.”
E.g. OF FUNCTIONAL COMPONENTS
Class / components
Source Potential benefit
1. Fatty acids
CLA
Milk & Meat Improve body composition, reduce cancers
ω-3 FA(DHA, EPA)
Fish oils, berseem & maize fodder,mustard,linseed,rapeseed
Reduce CVD & improve mental, visual function
2. Polyphenols
Anthocyanidin Fruits
Catechins
Flavonone
Tea,babul pods,mustard cake,rape seed
Nutralises free radicals, reduce risk of cancer
Flavones Citrus Fruits, vegetables,soya bean
proanthocyanidin •Cocoa, chocolate,tea,rape seed
Reduce CVD
Lipids
Fats are highly concentrated sources of energy for body.
Saturated fatty acidsMonosaturated (MFA)Polyunsaturated PUFA Saturated fats- animal based pdts
Lipids…MFA&PUF – plant origin
Trans fatty acids are pdts of partial
hydrogenation of PU fats and are
typically solids at room temperature.
MFA&PUFA do not promote formation of
the fatty deposits that can clog the
arteries
Lipids…Saturated FA—palmitic, lauric,
myristic acids are major cholesterol-elevating fatty acids in our diets.
Eskimos –diet rich in cholesterol + fat—free from heart diseases
Fish rich linolenic acid, found in fish + soyabean oils
linoleic acid –corn, soy bean oils
Linolenic acid- Omega 3 Linolenic acid (18:3n-3)- 18C, 3 double
bonds, the 1st being at C-3 from the methyl end.
CH3CH2CH=CHCH2CH=CHCH2CH=CH(CH2)7 COOH
precursor of : - Eicosapentaenoic acid -EPA (20:5n-3)
docosahexaenoic acid - DHA (22:6n-3) heart and brain & nerve function
Linoleic acid - Omega 6
CH3(CH2)4CH=CHCH2CH=CH(CH2)7COOH(18: 2n-6)
- precursor of arachidonic acid Prostaglandins, thromboxanes and
leukotrienes immunosuppressive effects and mediate
inflammatory responses platelet aggregation and vasoconstriction
CHOLESTEROL
cell membranes, brain and nerve tissues, steroidal hormones, bile acids.
Transported in bloodstream as a complex with molecules of proteins and fats, called lipoproteins.
Cholesterol is transported by both LOW DENSITY LIPOPROTEINS (LDLs) – most common and HIGH DENSITY LIPOPROTEINS (HDLs)
High levels of LDLs in the blood stream can lead to fatty plaque deposits on arteries and can predispose a person to have a heart attach (Bad cholesterol)
VITAMINSNeeded in small quantitiesFat soluble: A,D,E,KVit. A antioxidant – nightblindnessVit. D helps in bone strength.Water soluble- see later.
Vitamin E and C -Potent antioxidantsretard artery clogging and open them.
Help stop bad cholesterol (LDL, low-density lipoprotein) from being oxidised or turned rancid,
Probiotics
promote the growth of “friendly” bacteria, which
help, fight diseases.
Lactobacillus acidophillus: Acidophyllus type
support healthy bacteria for small intestine.
Bifidobacterium bifidum: Bifidobacteria support
healthy bacteria for large intestine.
Enhance the immune function.
Probiotics cont. Probiotics given to women around the time
of childbirth could protect children from atopic eczema for up to 4 yrs.
Controlling diarrhoea in children Offset S/E’s of antibiotics Ease symptoms of lactose intolerance. Sources: Sour milk, yoghurt, Yeast
(Saccharomyces spp)
Glucosamine-Glucosamine (an amino-sugar) is a nutrient
found in very small amounts in foodsnecessary for the formation of cartilage,
connective tissue and synovial fluid.-Useful in osteoarthritis, joint/connective tissue
injury Glucosamine – chondroitin combinationchondroitin -Naturally occurring sub that inhibit
the enzymes that degrade cartilagedraws fluid into cartilage thereby preventing it
from premature degeneration also acts as a building blocks for the creation of
healthy new cartilage
Centella asiatica, UmbelliferaeGotu kola, Herba centella, Hydrocotyle.
Indian pennywortHerbal teaAsiaticoside + derivatives of ursenoic acid. polyacetylenic cpds, flavone derivatives In animal experiments they promote
Thickening of skinIncrease local leucocytosisIncrease vascularization of connective tissueIncrease mucus secretion, hair and nail growth
Uses supported by clinical data
Rx wounds, burns and ulcerous skin ailments and prevention of keloids and hypertrophic scars
2nd & 3rd degree burnsTopically to accelerate healing, particularly in
cases of chronic post surgical and post trauma wounds
Rx of vein and skin disorders and in specific cosmetic products.
wound healing and tissue microcirculation and counteract such harmful venous processes as hemorrhoids and varices.
Evening Primrose Oil
-Fixed oil from seeds of Oenothera biennis (Onagraceae)
-Contains substancial amounts of esterified linolenic acid
-LA + 2 carbons gives arachidonic acid which is an immediate precursor of some prostaglandins.
Evening Primrose Oil..-Cosmetic purposes to improve skin, hair, and
nails-treatment atopic eczema and pre-menstrual
syndromePopular with women as an aid in regulating
the menstrual cycle.-Diabetic neuropathy-Rheumatoid arthritis
ALOEThe main commercial spp Aloe ferox.
Over 50 species e.g. A. secundiflora, A.
kendogenis, A. rabaiensis, A. tugensis, A.
elgonica, A. nyeriensis, A. keniense, A.
deserti, A. ukambensis
Parts used: juice, transparent gel from
leaves.
Aloe images
Aloe cont.Constituents: AQ glycosides, polysaccharidesProperties: Stress relief & suppression of peptic
ulcers, Treatment of radiation burns, wounds, skin
ulcers. Cosmetic skin prepns; eczema, -Arthritis, diabetes, HIV/AIDS? burns and skin irritationsLaxative Caution: juice should not be taken in pregnancy.
GINSENG
Panax ginseng
Used for centuries as a cure-all and tonic for
the body.
Traditional Chinese medicine for maintaining
physical and mental balance in human body.
Is an adaptogen = ‘harmony drug”
constituents: Saponins -ginsenosides
Ginseng cont.Promotes the release and manufacture of
adrenal hormones against stress.
Immunostimulatory: -increases RNA & prot
synthesis
- reduces protein degradation
-enhances antibody production
-increases interferon production
Ginseng…
Reduces BP, myocardial necrosis & cholesterol
Prevents liver damage to ethanol
Hypoglycaemic & stimulates insulin release
Inhibits growth of several types of cancers
-used as adjuvant in tumor chemotherapy.
-Available in 600mg capsule.
GINKGO Consists of dried leaves of Ginkgo bilobadiminished memory and concentration,
increased absent-mindness, confusion, energy loss, tiredness, depression, dizziness and tinnitus, dementia including Alzheimer’s. senility
-“Cerebral insufficiency” which could lead to dementia
Ginkgo biloba..Constituents: ginkgolides e.g. ginkgolide A,
B, C, M, J –diterpenes
bilobalide- sesquiterpenes,
flavonoid glyc, flavones, tannins + other
phenolics
Ginkgo has antioxidant, antiplatelet
aggregation and antiinflam activity.
ST. JOHN’S WORT- Hypericum
Hypericum perforatum (Guttiferaceae)For mild to moderate depression, anxiety and
nervous unrest-Compared with TCA’s- imipramine and
fluoxetine-Naphthodiathrone pigment hypericin,
hyperforin, C16 –C19 alkanes, pseudohypericin, xanthones, flavonoids
-Also antiviral-HIVH. keniese, H. kiboense, H. lanceolatum, H.
roeperatum
GINGER
-Zingiber officinale rhizome.-Compared with conventional drugs as
antinausea and travel sicknessNausea from anaesthetic effects after surgery-In hyper emesis gravidarum- a severe form of
nausea and vomiting related to pregnancyreduce the severity of nausea and the # of
vomiting attacks in cases of early pregnancy-and safe
-Gingerols and shagoals – Non volatiles, essential oils
GARLIC
Consists of bulbs of Allium sativum.-Anti cholesterol and anti thrombotic-inhibit
platelet aggregation-Antibacterial, antifungal, antiviral, anti tumor
and anti diabetic Useful in patients with old or acute myocardial
infarcation.- B.P. ,arteriosclerosisIt helps regulate cholesterol levels and
maintain heart health. Sulphur containing - ajoene, allicin, alliin
Milk Thistle-Silybum marianumprevent liver damage, regenerating cells and
large areas of liver tissue damage. treat acute and chronic viral hepatitis B, fatty
liver, cirrhosis and toxin-induced injury,radiation, etc
Milk Thistle…Flavolignans- Silymarins
Silybin
-Antioxidant-preventing damage to
healthy liver cells and stimulating a
regeneration of the injured liver cells.
Milk ThistleSilymarins stands guard on the outer receptor
sites of cells, baring toxins from breaking
through fatty cell membranes and entering cell
-Neutralizes toxic subs that manage to penetrate
Stimulates natural antioxidants in the body
-Stimulates protein synthesis
NEEM TREE (mwarubaine)
Azadirachta indica Coastal Neem Melia azadiracht – Highland NeemFamily MeliaceaePolvalent medicinal properties. “village
doctor”Antibacterial and antifungal properties-
preparation –skin preparation including soaps
NEEM TREE..Toothpaste- protect teeth from decay and
tooth rot and gum disordersInsecticide – insecticidal + antimoulting
(azadractin) Antimalarial activity –Boiled leaves (gedunin
and nimbolide)Antidiabetic (nimbinin and nimbadiol)
NEEM TREE..Leaves - Rx diabetic mellitus and juvenile
diabetes insulin Cardiovascular and Nervous activityAntifertility-Neem oil exerts spermicidal
activity, reversible May also prevent implantationAntihelmintic
NEEM TREE..Rx ringworm (antifungal) and intestinal
worms.Increase immune response in mice. Stomach ulcers- effectiveGalactologue (increase milk)Rx haemorrhoidsRx certain cancers
NEEM TREE..Increase immune response in mice. Stomach ulcers- effectiveGalactologue (increase milk)Rx haemorrhoidsRx certain cancers
COMPOSITIONTetranortriterpenoids Azandiractin, gedunin and nimbolideGedunin, gedunin and nimbolideFlavonoids Limonoids TanninPolysaccharides, Glycoproteins