nutritional therapies for mental health - dr. leslie korn...glandular benefit dose range adrenal...
TRANSCRIPT
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LeslieKorn,PhD,MPHLMHC,ACS,RPP,NTP,NCBTMB
CopyrightDr.LeslieKorn,2020
Nutritional Therapies for Mental Health
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Principle
“Diet is essential but not sufficient”
— Leslie Korn
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Ethics & Nutritional Supplementation
• Rememberourethicsmodule&yourroleinnutritionalsupplementation
•Dependsonthestatewhereyoupractice• Yourscopeofpractice• Competency
• Identifyyourroleasprimaryorreferring&collaborative• Betheclinicianwhoknowsabouttherangeofoptionsevenifyoudon’trecommendorprescribe
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•AddressCauseofdis-ease/imbalances•⬇inflammation&oxidativestress•Managestressresponse•Enhancemitochondrialfunction•BalanceCircadianrhythm•Enhanceneuronalcommunication•AddressEpigenetics• Howfoods&nutrientscanaltergeneexpression
Goals of Nutritional Therapy
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Goals of Nutritional Therapy
• IdentifyBiochemicalindividualneeds• Enhancedigestion&utilizationofnutrients• Delivereasilyassimilatedhighdosenutrients•Manage/reduce/eliminatesymptoms• Alternatives/synergiststopharmaceuticals• Identifyadherencestrategiesincludingdose&delivery
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Supplement Dosing
•Treattheindividual,notthedisease/symptom•Spreaddesiredeffectsacross4broadareas
• Vitamins,Minerals,AminoAcids&Glandulars
•Tailorprotocoltoclientneeds•Planforincrementalchange•Lowerdosesthat⬆slowly•Adjustchildren’sdoses•Age&bodyweight
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Supplement Dosing
•Highquality,naturalformsupplements
•Lookforfoodsourcesofvitaminsonlabelor100%natural
•Readlabels• Lowerqualityvitamins(additives,fillers&foodcoloring)
•Useafewsupplementstocombinemostofwhatyouneed
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•Balanceuseofvitamins,minerals,fats,botanicals&glandulars
•Review&adjusttheprotocolevery3-6months
•Startslowly&buildaccordingtoadherence
•Startw/whereyouwillobservefastest&mostimportantchangesfirst;eg.Anxiolytic/antidepressantetc.
Dosing: Vitamins, Minerals, Botanicals & Glandulars
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Contraindications & Side Effects
Nutrients may • Slowor⬆metabolism• Excretionofcertainmedications
• Potentiate/synergizeactionofcertainmedications
• Exacerbateexistinghealthconditions
•Becontraindicated
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•5-HTP,Melatonin•Kava,St.JohnsWort
•Mixingofnutrients,drugs&herbs•Nutrientdeficitsasaresultofmedications
•Comprehensivedrug-nutrient-herbanalysis
Keeping Your Clients Safe
www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker
http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker
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Best Vitamins, Minerals, Amino Acids, Fats, Glandulars, & Special Nutrients
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•B-Vitamins&Minerals•FreeAminoAcids•Fats(dietary&supplemental)
•Probiotics•Glandulars
Core Nutrients for Mental Health
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•Integratefood&nutrients•Usepowdered/liquidnutrients•AddFish&Borage/CoconutOils
•Probioticspowder•Protein(whey,pea,hempprotein)
•Berries,Chocolate,Stevia
How to Take Nutrients? Smoothies
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Essential Vitamins
Vitamins •Water-soluble•Dissolvedinwater&arenotstoredinthebody•Riskofoverdosingisverylow
•Fat-soluble•Absorbedbyfat•Requiresufficientdietaryfatstobestoredinbodytissues
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•Neurohormonenotavitamin•AnnualserumVitaminDtesting:levels50-80/ng/mL•VitaminDreceptorsinbrain⬆serotoninproduction(Holick,2003)•ImprovesMitochondrialfunction•Deficiencyassociatedw/depression&pain,immuneproblems•High%ofdeficiencyinUSpopulation• Sinha,Hollingsworth,Ball,&Cheetham,2013
First Steps: Vitamin D Deficiency
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Vitamin D
• Helpsbodyabsorbcalcium,magnesium,phosphate,iron,&zinc• CholesterolisaprecursortovitaminD• (Vasquez,Manso,&Cannell,2004)• 5000IU/dayor• Oraldoseof50,000IUofvitaminDonceaweekfor8weeks• Long-termprevention=50,000IUofvitaminDonceortwiceamonth• Emulsifieddrops
• Holick,Michael.DepartmentofMedicine.DivisionofEndocrinology,Diabetes,andNutrition.BostonUniversitySchoolofMedicine,Boston,MA.
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B Complex Vitamin
•StartwithB-complex•Coresupportforbrainfunction
• eg.B-6supportsNTfunction;supportsbloodglucose
•Relaxation,cognition, &neurologicalhealth
•➡cofactorsinneurotransmitters
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Vitamin B9
•Folate,naturalform• Invarietyofplant&animalfoods
•Folicacid,syntheticform•Usedinsupplements&fortifiedfoods
•Strongcorrelationbetweenadeficiencyinfolate&depression
•Avoidfolicacid
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•MTHFR(Methylenetetrahydrofolatereductase)• Enzymeneededtoconvertfolate• ConvertshomocysteinetomethionineessentialforNTdevelopment
•GeneticMTHFRvariation:estat40%unabletoconvert• Individualswiththisgeneticvariation(Singlenucleotidepolymorphism(snp)take
• Implications?depression,bipolardisorder,schizophrenia,attention-deficithyperactivitydisorder(ADHD),autism,homocysteine
Folate, 5-MTHF & Genetics
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Vitamin B9& MTHFR
•Take:L-methylfolate,fewtonosideeffects• Ifsystemicinflammationishigh:experienceirritability, &insomnia
•Startatlowdose• IncludesupplementalMethylB-12,&Niacin
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Vitamin B3
•Niacin&niacinamide• Depression,anxiety,&alcoholaddiction•Niacincauses(unpleasant)flushing
•Niacinamide➡GABAreceptors•Moodstabilization&sedative,arthritis,•Anxiety,depression,insomnia,dementia&alcoholwithdrawal(Prousky,
2005)
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Vitamin B3
• Largedosesforschizophrenia(Hoffer,1962)• 15gramofL-methylfolate(or500mgofthiaminet.i.d.)• 3-8gramsofNiacinamide,toimproveoutcomesalongsidetheuseconventionalantipsychotics(Lake,2006)
Contraindications
•Niacinabove3,000mg.aday:monitorresponsewithhealthprofessional
• Possiblenausea&vomitingathighdoses
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Vitamin B6
•B6deficiency➡insomnia,hypertension,PMS,&irritability
•Depression&anxiety•SSRIformulationsoftencontainaddedB-6
•Pyridoxal5’-phosphate(P5P):preferredform•(50-100mg)•ActivecoenzymeformofvitaminB6
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Vitamin B8
• Inositoleffectivefordepression,panicattacks,agoraphobia,obsessivecompulsivedisorder,bulimianervosa,&bingeeating
(Gelber,Levine,Belmaker,2001)
•⬇OCDsymptoms• (Levine,1997)
•MoreeffectivethanfluvoxamineinthereductionofOCDsymptoms
(Gelberetal.2001)
Startat2000mg. Highdosesabove10,000mgcanupsetstomach
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Vitamin B12
•B12--essentialvitamin•Depression,fatigue,anxiety,cognition&psychosis•Co-factorinmethylationleadingtoSAMe•Sublingual:1-5mg/day•Elders,lowproteinandvegetariansatrisk•MetformindepletesthebodyofB12• (Prousky,2005)
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Choline
•Naturallyincellmembranelipidsinbrain• Beefliver,egg,fish,chickenandmilk•Synthesisofacetylcholine:memory&learning•3commonlyusedforms•CDP-Choline(cytidine-5’-diphosphatecholine)A.K.A.citicoline
•BreaksdownintoPhosphatidylcholine•ThenintoAlpha-GPC
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Choline
Vegetarians,vegansandexcessamountsofalcoholincreaseriskofcholinedeficiency
CDP-cholineacceleratedrecoveryinheadtraumapatients(Secades&Frontera,1995)
• 500mg.CDP-cholinetwicedailymayhelp⬇cravingsforcocaine(Renshaw,Daniels,Lundahl,Rogers,&Lukas,1999)
• Combinedwithlithium(carbonate)reducesmanicsymptomsinbipolardisorder
(Lyoo,Demopulos,Hirashima,Ahn,&Renshaw,2003)
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Vitamin C
•QualityvitaminCisaComplex(notjustascorbicacid)
•Containsbioflavonoids&rutin
•Eatingcitrusfruits’pulpprovidesbioflavonoids
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Fat Soluble Vitamins
•A•D• E•K•Needfattoabsorbtheseessentialvitamins•Besttakenw/ahigherfatmeal• Lowfatdietsatriskfordeficiency
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Vitamin A
•Agroupofcompoundscalledretinoids•Eyes•Immunesupport•Skin•Lungs
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Vitamin E•8fat-solubleantioxidantcompounds•Tocopherols&tocotrienols•⬆vitaminEassociated•⬇riskofcognitivedecline/Alzheimer’s
• Evidencesuggeststakingseparately• Tolowerinflammationmarkers
• 250mg/day.Annatto-derivedtocotrienols• (Mangialascheet.al.,2012,2013)
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Vitamin K•SupplementationshouldincludebothformsK1&2•K1(phylloquinone):Higherlevelsassociatedwithbettercognitivefunctioninelders(Presseetal.,2013)
• K2(menaquinone):essentialfornervehealthinthebrain
• 100mcgofvitaminK2(MK-7)• 1,000mcgofvitaminK2(MK-4);&1,500mcgofvitaminK1• Oralanticoagulantsdoubleratesofdepression
Contraindications: People taking anticoagulants (Warfarin) https://academic.oup.com/ehjcvp/advance-article/doi/10.1093/ehjcvp/pvz085/5699907
https://academic.oup.com/ehjcvp/advance-article/doi/10.1093/ehjcvp/pvz085/5699907https://academic.oup.com/ehjcvp/advance-article/doi/10.1093/ehjcvp/pvz085/5699907
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Essential Minerals
• “Sparkplugs”(Watts,2006)•Macrominerals•Bodyneedstheminlargeramounts•Calcium,phosphorus,magnesium,sodium,potassium,chloride&sulfur
• Traceminerals• Smallamounts• Iron,manganese,copper,iodine,zinc,cobalt,fluoride&selenium
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Chromium
•Depression&moodregulation•Effectiveindecreasingcarbohydratecravings&bingeeating(Brownley,VonHolle,Hamer,LaVia,&Bulik,2013)
•Chromiumpicolinate500-1000mcg
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Calcium
•Overuseofcalciumsupplementsbypost-menopausalwomen
•➡fatigue,exhaustion,headaches,depression,anxiety&insomnia
(Watts,2006)
•Overconsumptionmayinhibitzinc,phosphorous,&copperabsorption
•Handout:Calcium-richsouprecipe
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Lithium
•UseforcognitionandMooddisorders(Schrauzer&deVroey,1994)
• LengthensCircadianRhythm•Neuroprotective&anti-inflammatory•⬆hippocampalvolume,⬆brainderivedneurotrophicfactor(BDNF)
•⬇riskofAlzheimer’sinbipolarpatientswhotakeitregularly
(Diniz,Machado-Vieira,&Forlenza,2013)
• LithiumOrotate20-50mg
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Lithium
• Peoplew/BiPolar,depression,cognitivedecline&memoryloss(Forlenzaetal.,2011);(Nunes,Viel,&Buck,2013)
• Alcoholrecovery&relapseprevention(Sartori,1986)
• Lithiumorotatecrossesblood-brainbarrier• Carbonateformdoesnot
Contraindications •Nottobetakenbypregnant&lactatingwomen
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Magnesium
•Anxiolytic,anti-stress•Supportscognitivefunction&mood•Deficiencyiscommon•Improvesserotoninsynthesis•Reducesinflammation&oxidativestress•Muscletension,sleep•Aspartate:aseffectiveaslithiumin50%ofseverelyillrapid-cyclingbipolarpatients
(Chouinard,Beauclair,Geiser,&Etienne,1990)
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Magnesium
•Mostabsorbableformsofmagnesium• Glycinate• L-threonate,anewformdevelopedtocrossthebloodbrainbarrier.Improvesshort-termmemory
(Abumariaetal.,2011)
•⬆overallcognitivefunction(Slutskyetal.,2010)
• Antidepressant&candampentraumaticmemories(Abumaria,Yin,Zhang,Zhao,&Liu,2009)
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Magnesium Threonate
•Significantly⬆levelsofmagnesiumwithinbrain
•Maintainsthequantityofsynapticconnectionsbetweenbraincells
•Improvedshort&longtermmemory(SlutskyI,AbumariaN,WuLJ,HuangC,ZhangL,LiB,ZhaoX,GovindarajanA,ZhaoMG,ZhuoM,TonegawaS,LiuG.2010)(LiW,YuJ,LiuY,HuangX,AbumariaN,ZhuY,HuangX,XiongW,RenC,LiuXG,ChuiD,LiuG1.2014)
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Potassium
•Deficiency➡Bulimia&anorexia
(Higdon,2004)
•Potassiumorotate&citrateveryeasilyabsorbed
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Selenium
•Elevatesmood,reducesinflammation,enhancesimmunity
Contraindications •Veryhighdosesofseleniumcanbetoxic
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Zinc
•Antidepressant(Levenson,2006)
•Cognitivefunctioninelderadults
(Mayloretal.,2006)
•Useinbulimia&purging,anorexiadisorder
•Picolinate25-50mg/day
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Copper
•Regulatescellularenergyproduction&neurotransmission
•High&Lowcopperlevelslinkedtodepression• Source:wellwater
•Antacidsinterferew/theabsorptionofcopper
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Iodine
•Foodsources• Seafood,seaweed&iodizedsalt
•Benefitsfatigue,ADHD&ASD
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Iron
•Irondeficiency⬆riskofmooddisorders,autismspectrumdisorder,attentiondeficit,hyperactivitydisorder
(Chenetal.,2013)
•Irondeficiency⬆fatigue,anemia,poorcognitivefunction&developmentaldisorders
•VitaminC⬆ironabsorption•Cookw/castiron•Floradix
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Rubidium
PrimarydietarysourceofRbisredmeat. Processedmeatscontainahighconcentrationofrubidium. Brazilnuts,pecans,sesameandsunflowerseeds,potatoskins, eggplant,mushrooms,cucumber,avocado,andmeatbones
Usefordepressionspecificallystimulatescatecholamine(dopamine, norepinephrine; and epinephrine) pathways
Activatesthesynthesisof5-hydroxytryptophan
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Rubidium
Usefordepressionindialysispatients
MerckManual,1940:useashypnoticand‘nervousafflictions”
500mg/dayRB-zyme
https://www.ncbi.nlm.nih.gov/pubmed/8412574https://www.ncbi.nlm.nih.gov/pubmed/8926857
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Antioxidants
• Body’ssystemofprotection➡neutralizefreeradicals• Excessoxidation➡toomanyfreeradicalsforantioxidantstoneutralizethem➡“oxidativestress”• ⬆Celldestruction• N-acetylcysteine• Boostsproductionofglutathione• Alphalipoicacid• CoenzymeQ10(CoQ10)• MilkThistle
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Probiotics
•FermentedfoodsorSupplements
•Heatstabilizedorneedrefrigeration•Intakeofprobioticsmayreducenegativethoughtsassociatedw/sadmood
(Steenbergen,Sellaro,vanHemert,Bosch,Colzato,2015)
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Essential Fatty Acids
• DHA,aconstituentoffishoil•⬆communicationbetweensynapses•⬆dendriticspinesonpostsynapticneurons• Higherbloodlevelsoffishoil=w/⬆brainvolume
(Pottalaetal.,2014)
• TheFishOilYouthDepressionPilotStudy(1.4gms)• Min.of2000mgadayforeffect• Upto20gm.dailyoffishoilforthetreatmentoftraumaticbraininjury(Lewis,Ghassemi,&Hibbeln,2013)
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Gamma Linoleic Acid (GLA)
●GLA-richplantoils●Borageseed
● derma●Eveningprimroseseeds
● menopause●Blackcurrantseed●Uterinecramp/PMS●Hemp●500-1000mg/day
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Medium Chain Fatty Acids & Cognition
•⬆ketonebodies:improvescognition&memory
•SignificantresearchforMCT&cognitiverepair•Promotes&nourishesneuronalcommunicationby⬆growthofdendrites(nerveendings)
•Coconut,Palm(lesseringrassfedbutter)•AddrawButter&coconutfattocoffee
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•Aminoacidsareprecursorstoneurotransmitters
•Productionofneurotransmittersisaffectedbyaminoacidsindiet
•Poordiet/lowprotein⬇neurotransmitters•PoorFats⬇neuronalcommunication•EFA’saresynaptic“lube”
Amino Acid Therapy
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Amino Acids
•Aminoacidtherapies=alternativetopsychotropicpharmaceuticalmedications
•Freeaminoacids
Contraindications •Peoplew/tardivedyskinesiashouldnottakephenylalaninesupplements
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NT’S AMINO ACIDS/ NUTRIENTS BOTANICALS FOODS ENTHEOGENS
GABAGlutamine,taurine, lactium,
LithiumorotateValerian,hops,skullcap,
greentea,kava
Walnuts,oats,spinach,beansliver,
mackerel
Amanitamuscaria,Muscimol
SerotoninTryptophan, 5HTP,B-vitamins,(B-12,
B-6niacinamide),folateSt.John’swort
Salmon,beef,lamb,figsbananas,root
vegetables,brownrice
LSD,Psilocybin,DMT,Ibogaine,Ayahuasca
Dopamine Tyrosine,DL- Phenylalanine,B-12,B-6 Ginseng,FenugreekCoffee,tea,eggs,
pork,darkchocolate,ricottacheese
MDMA/MDE Mescaline
Norepinephrine Tyrosine StJohn’swort,Holybasil,licorice Meats,fishescheeseMDMA/MDE Mescaline
AcetylcholineGPCcholine, phosphatidylserine, acetyl-L-carnitine, huperzine
Sage,Bacopa,Melissa,Ginkgo,Ashwaganda
Eggs,liver,salmonshrimp,nutbutters,
coffee
Scopolamine(contraindicated)
Glutamate GlutamicAcid GotuKola,Kava,PassionflowerCaffeine,fermentedfoods,chicken,eggs,
dairy
Ketamine Ibogaine
Endogenousopioids
Lactium PapaversomniferumCasein(milk),gluten(grains),spinach,fat,
fasting
Ibogaine, Salviadivinorum
Cannabinoids Fishoil,lactobacilli Cannabis Hempseeds/hempoil Cannabis
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Theanine
•Aminoacidfoundingreen&blackteas
•Crossestheblood–brainbarrierwhereitactsasananxiolytic
•Canenhancedreams
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•FreeAminoAcids•B-ComplexwithB-6&B-12•Magnesium•Theanine•Curcuminw/BlackPepper•Tyrosine(rhodiola)•Eggs,Eggs&moreEggs-Acetylcholine
Top 7 Nutrients Essential for Neurotransmitter Balance
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Coenzyme Q10
•Vitaminlike,fat-solublesubstancefoundinmitochondria•Twoforms:ubiquinol&ubiquinoneubiquonolmaybemoreeffective
•Beneficialfortreatmentofbipolar,depression,fatigue,fibromyalgia&schizophrenia,mitosupport
Contraindications • Canreducethebody’sresponsetobloodthinning(anticoagulant)medicine• Can⬇insulinrequirementsinpeoplew/diabetes
• Stainsdepletethereforeneedtosupplement
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Lactium
•DevelopedinFrance•Genericnameofbioactivemilk-derivedpeptides•ActsonGABAreceptors•⬇stress&cortisollevelswhileinducingrelaxation&improvingmentalfunction
•⬆sleep
(Clare&Swaisgood,2000);(Delini-Stula&Holsboer-Trachsler,2009);(deSaint-Hilaire,Messaoudi,Desor,&Kobayashi,2009)
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Melatonin
•Hormonesynthesizedasthefinalmetabolitebythetryptophan-serotoninpathway
•Theuseoftryptophanor5-HTPmayeliminatetheneedformelatonin
Contraindications •Alpha-&beta-blockingdrugsusedforhypertensioncandisruptsleepby⬇melatoninrelease
(Stoschitzkyetal.,1999)
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Phosphatidylserine
•Phospholipid:keycomponentofcellmembrane•Essentialfortransferofbiochemicalmessagesintocellswithinbrain¢ralnervoussystem
•RegulatescortisollevelsviatheHPA-axis•⬆acetylcholineinbrain•Supportsmemoryinchronicstress,depression,ADHD,PTSD&TBI
•Eggyolks&liverrichPSsources•100/mgdayHPAaxis
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Bromelain
•Inhibitscyclooxygenaseenzyme•Inhibitssynthesisofprostaglandin2
•Breaksdownfibrin&reducesswelling
•Foundationofanti-inflammatorytreatment
•Useforpain&fibromyalgia (withCoq10)
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RNA/DNA Supplements
• Recoveryfromillness&surgery• Cognitivefunction• Immunesupport• Diet• Proteins,synthesisfromaminoacids&glucose
• Supplements• Four“ribonucleotides”CytidineMonophosphate(CMP),UridineMonophosphate(UMP),AdenosineMonophosphate(AMP),&GuanosineMonophosphate(GMP)
• Enhancebrainphospholipids&learning• Cognitex(w/w/oPregnenalone)
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Glandulars-Foods & Supplements
•Brain•Hypothalamus•Pituitary•Adrenal•Thymus•Liver•Heart•Thyroid•Lung
TraditionalFoods•Tripe•Lung/Chanfaina•Thymus(sweetbread)•Heart•Liver•Tongue•Testicles•Kidneys•Blood
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GLANDULAR BENEFIT DOSERANGE
Adrenal
HelpsthebodyrespondtostressSupportsimmunefunction
Supportsmetabolism&physiologicalfunctionofadrenalglands
Addressesfatigue,sugarmetabolism,andweightloss
100mgb.i.d.aor200mgt.i.d.a
AdrenalCortex Helpstosupportahealthystressresponse 250mg(1,t.i.d.)
Brain SupportsHPAaxis,depression 250mg(1-2,t.i.d.)
Glandular Supplementation
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GLANDULAR BENEFIT DOSERANGE
Hypothalamus SupportsHPAaxis,depression,TreatmentofTBI 500mg(1-3,t.i.d.)
Liver Supportsliverinalcohol&drugrecovery,detoxification,chemicalsensitivity 400mg(1-2,t.i.d.)
Pancreas
Supportdigestion Maysupport&modulatetheimmunefunction Maysupportbloodglucosewithinnormallimits Supportspancreaticfunction&fatdigestion
400mg(1-2,t.i.d.)
Pituitary SupportHPAaxisdepression 250mg(1,b.i.d.)
Glandular Supplementation
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GLANDULAR BENEFIT DOSERANGE
Thymus Immunefunction 1,000mg(1-2,t.i.d.)
Thyroid Lowthyroidfunction 40mg(1-2,3x/day)
Glandular Supplementation
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Myer’s Cocktail IV Supplements
•Magnesium•Calcium•VitaminsB12,B6,&C•UseforMigraines• Fatigue(chronicfatiguesyndrome)
• Fibromyalgia•Acutemusclespasm•Drug/alcoholrecovery
(Gaby, 2002); (Massey, 2007)
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• Educatetheclient:roleofnutritionalsupplementationinwell-being• Prioritizecorenutrients
• Supplements/foods(e.g.probioticssupplementsorfreshfermentedfoodsorboth)
• Adjunctnutrientprotocol• Reviewassessment:matchspecificmodesofingestion (e.g.smoothies,capsules,andliquids,IVetc.)
• Applydrug/nutrientinteractionsdatabase• Considerconsultationw/prescribingorexpertclinician• Identifyobstacles/challengestoadherence
Protocol Design
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Chronic Pain
• ChronicPainiscomorbidw/depression,similarapproachtotreatment• 5HTP5-hydroxytryptophan• D,L-phenylalanine• Foracutepain,useitat250mgevery2hours• Forchronicpainordepression,use500mg3timesaday
• Fishoil• Capsaicin(topical)• CompoundedKetoprofen,Ketamine,Capsaicin
• CBD-richtincture
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Depression - Part 1NUTRIENTS DOSE
Complexvitamins&mineralswithL-methylfolate
Dosevariest.i.d.
Omega-3fishoil 1–3gramso.d.
Gammalinoleicacid(GLA)/borageoreveningprimroseoil
1,000mgo.d.
Freeaminoacids Dosevariesb.i.d.
Probiotics 100+billionCFUso.d.
VitaminD50,000IU(oral,1x/weekfor 8weeks)fordeficiency 2,000–4,000IUo.d.formaintenance
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Depression - Part 2NUTRIENTS DOSE
GlucoseTolerancefactor 1-2capsulest.i.d.
VitaminB6 10mgq.i.d.
Niacinamide Niacinamide
Methylcobalamin 1-2mcgo.d.
LithiumOrotate 50-150mgo.d.
Magnesium 400mg
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Depression - Part 3NUTRIENTS DOSE
5-HTP 50-100mgo.d.
Or/Tryptophan 50-100mg
L-Tyrosine 250-500mgb.i.d.
AdrenalGlandular 100-200mgt.i.d.
HypothalamusGlandular 500-1500mgb.i.d.
Melatonin 0.5-1mgo.d.
Lactium
OrthophosphoricAcid 30dropso.d.
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Seasonal Affective Disorder - Part 1NUTRIENTS DOSE
Complexvitamins&mineralswithL-methylfolate
Dosevariest.i.d.
Omega-3fishoil 1–3gramso.d.
Gammalinoleicacid(GLA)/BorageorEveningPrimroseOil
1,000mgo.d.
Freeaminoacids Dosevariesb.i.d.
Probiotics 100+billionCFUso.d.
VitaminD50,000IU(oral,1x/weekfor8weeks)fordeficiency2,000–4,000IUo.d.formaintenance
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Seasonal Affective Disorder - Part 2NUTRIENTS DOSE
GlucoseToleranceFactor 1-2capsulest.i.d.
VitaminB6 50-100mg.o.d.
Tryptophan 500mg.o.d.@night
Melatonin 0.5-1mgo.d.night
SAMe 400-600mgo.d.
Wheyprotein 2heapingtablespoonso.d.
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Alcohol - Part 1NUTRIENTS DOSE
Complexvitamins&mineralswithL-methylfolate
Dosevariest.i.d.
High-dosePhosphorylatedThiamineB-VitaminMineralComplex
1-2mcgo.d.
Omega-3FishOil(DHA/EPA) 1-2gmt.i.d
GammaLinoleicAcid(GLA)/BorageorEveningPrimroseOil
1000mgo.d.
FreeAminoAcids Dosevariesb.i.d.
Probiotics 100+billionCFUso.d.
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Alcohol - Part 2NUTRIENTS DOSE
VitaminD50,000IUor/
2000-5000IUo.d.
GlucoseToleranceFactor 1-2capsulest.i.d.
CDP-Choline 500mgb.i.d.
LiverGlandular 400mgt.i.d.
AdrenalGlandular 200mgt.i.d.
HypothalamusGlandular 500mgt.i.d.
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Alcohol - Part 3NUTRIENTS DOSE
Niacinamide 500mg
Magnesium 1-2capsulest.i.d.
Potassium 500mgb.i.d.
Lithiumorotate 400mgt.i.d.
5-HTP 200mgt.i.d.
Tryptophan 500mgt.i.d.
Melatonin 0.5–1mg
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Alcohol - Part 4
NUTRIENTS DOSE
Phosphatidylcholine 800-1200mgb.i.d
SAMe 400mgb.i.d.
Lactium
(w/Anxiety)150-300mgo.d.
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Anxiety - Part 1NUTRIENTS DOSE
Complexvitamins&mineralswithL-methylfolate
Dosevariest.i.d.
Omega-3fishoil 1–3gramso.d.
Gammalinoleicacid(GLA)/BorageorEveningPrimroseOil
1,000mgo.d.
Freeaminoacids Dosevariesb.i.d.
Probiotics 100+billionCFUso.d.
VitaminD50,000IU(oral,1x/weekfor8weeks)fordeficiency2,000–5,000IUo.d.formaintenance
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Anxiety - Part 2NUTRIENTS DOSE
B6pyridoxalphosphate 50mgb.i.d.
B-12methylcobalamin 1,000mcgo.d.
Niacinamide 500mgb.i.d.
MagnesiumL-threonateorglycinate 100–400mg
AlphaGP-choline 600–1,000gramso.d.
Tryptophan 500mg
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Anxiety - Part 3NUTRIENTS DOSE
Lactium 150–450mgasneeded450–600mgforsleep
Orthophosphoricacid 30dropso.d.
Lithiumorotate(Depression&moodlability)
45mgo.d.(Shealy,2006)
Taurine(Highbloodpressureorgallbladderissues)
500–1,000mgt.i.d.
Glycinestrips(Acutepanic) 2g(sublingually)everyfewminutes(Prousky,2005)
Phenibut 250–500mgo.d.
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Anxiety - Part 4
NUTRIENTS DOSE
Adrenalglandularstress 100mgb.i.d.or200mgt.i.d.
Stabilium(Garumarmoricum)(Useifcaseinallergy)
200–400mgo.d.
Oralmicronizedprogesterone(Prescriptiononlyformenopausalwomen)
50–100mgo.d.
Phosphatidylserine(Posttraumaticstressdisorder)
100mgt.i.d.
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Sleep/Wake Disorders - Part 1NUTRIENTS DOSE
Complexvitamins&mineralswithL-methylfolate
Dosevariest.i.d.
Omega-3fishoil 1–3gramso.d.
Gammalinoleicacid(GLA)/BorageorEveningPrimroseOil
1,000mgo.d.
Freeaminoacids Dosevariesb.i.d.
Probiotics 100+billionCFUso.d.
VitaminD50,000IU(oral,1x/weekfor 8weeks)fordeficiency 2,000–4,000IUo.d.formaintenance
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Sleep/Wake Disorders - Part 2NUTRIENTS DOSE
Glucosetolerancefactor 1–2capsulest.i.d.
B-12methylcobalamin 1mgo.d.
Magnesiumthreonate 100–400mgo.d.
LithiumOrotate 1.5mgo.d.
Alpha-lipoicacid 200mgo.d.
Melatonin 0.5–1mgnight
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Sleep/Wake Disorders - Part 3
NUTRIENTS DOSE
Lactium 450–600mgo.d.
5-HTP(optional) 25–100mgo.d.
Phenibut(optional) 250–500mgo.d.(reduceafter1monthtoeveryotherday)
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• VitaminCtosaturation=10,000to20,000mgperday&more• 1000mgofvitaminCeveryhour.
• Saturation=singleepisodeofdiarrhea• Then⬇thedosageto1000mgevery4hours
• L-Glutamine(2000or3000mg)• ⬇physiologicalcravingsforalcohol.L-Glutamineisnaturallyproducedintheliver&kidneys
• Lecithin(2to4tablespoonsdaily)• Inositol&choline,relatedtotheB-complex• Lecithinalsohelpsmobilizefatsoutoftheliver
Dr.Abram Hoffer’s Protocol for Alcohol Recovery
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• Chromium• 200-400mcgchromiumpicolinatedaily• Chromiumgreatly⬇carbohydratemis-metabolism,&greatlyhelpscontrolbloodsugarlevels
•Magnesium(400mg)&theantioxidantscarotene&d-alphatocopherol
Dr. Hoffer’s Protocol for Alcohol Recovery
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Copyright,LeslieE.Korn,2020
Cognitive Impairment
• Trans-Fats=riskfactor• Intensivenutrientsupportdiet&exercisecanreversedecline&slowitinlaterstages• Lotsof(mis)diagnosesrelatedtomood&cognition
• Severaltypesofdecline• Noninflammatory-lowzinctypeAD• Mold
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Copyright,LeslieE.Korn,2020
Alzheimers: Diabetes Type 3
• “Whatoccursintheheartoccursinthebrain”
•Inflammation(turmeric;hops&rosemarysuppressinflammatorycytokines)
•Blood/Oxygenflow(gingko,vinpocetine,VitaminE,HBOT)
•Insulinresistance(⬆adrenal/livereliminategrains/sugars)
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Copyright,LeslieE.Korn,2020
Alzheimers: Diabetes Type 3
•Lossofbrainvolume(Brain,hypothlamus,CES,fats)•Impairedneurotransmitterfunction•Hormones(DHEA,estrogentestosterone)•Toxicaccumulations
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Copyright,LeslieE.Korn,2020
Cognitive Function & Mood Elevation
•Coffee/BlackTeaw/MCT/RawButter;KetoDiet • Foods:Eggs,Liver •AminoAcids5-HTP(25-200mgs) •Glandulars:AdrenalbrainHypothalamus •Depression&Cognitionadd • Acetyl-Lcarnitine,GPCcholine(AlphaGlycerylphosphorylcholine)Gingko&Huperzine • (Note:somepeoplegetheadacheswithGingko)(notforuseduringpregnancy/lactation)
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Copyright,LeslieE.Korn,2020
Cognitive Function Protocol
•Huperziaserrata/ChineseClubMoss•HuperzineA,(acetylcholinesteraseinhibitor)•⬆acetylcholine⬆memory⬆learning• 50-200mcg.Daily
•Bacopamonniera(Ayurvedicplant,Brahmi,waterhyssop)• 300-600mg(totalbacosidecontentat55%oftheextract)• Takewithfattymeal
• BensonS,DowneyLA,StoughC,etal.Anacute,double-blind,placebo-controlledcross-overstudyof320mgand640mgdosesofBacopamonnieri(CDRI08)onmultitaskingstressreactivityandmood.PhytotherRes.2014Apr;28(4):551-9.
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Copyright,LeslieE.Korn,2020
Cognitive Function Protocol
•Acetyl-L-carnitine(ALCAR):crossesbloodbrainbarrier•⬆acetylcholine;⬆nervegrowthfactorinbrain,aproteinforlearning&memory.⬆metabolism
•⬆Enhancescellularenergy,⬇insulinresistance
• 250-500mg(am)• Potentiatesw/alphaGPC(glycero-phosphocholine)&RLipoicacid
• CombineHuperzine,Bacopa,R-Lipoicacid&ALCAR
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Copyright,LeslieE.Korn,2020
Cognitive Function Protocol
• LithiumOrotate40mg/day
• RNA/DNA• Enhancecognition,memory,TBI,circulation
• Phosphytidalserine100mg/day• RegulatestheHPAaxis&supportsnervecelltransmission
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Copyright,LeslieE.Korn,2020
Glandulars for Cognitive Function
•Brain •Hypothalamus&Pituitary •Adrenal •Liver(mood+anger)•Heart•Thyroid
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Copyright,LeslieE.Korn,2020
Sundowning / Dementia
• Sundowning:agitation,confusion&anxietyinlateafternoon/evening•⬇productionofmelatonin• Deteriorationofsuprachiasmaticnucleus(SCN)•⬆2hrs.ofmorningbrightlight• Melatonin• CherryChamomilesmoothie• Pituitary/Hypothalamus500-2000mg• Cranial/Sacraltherapy&HandMassage• Melissaaromatherapy
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Copyright,LeslieE.Korn,2020
• Andropause • LowT- Depression,irritability,lowlibido,bellygain
• PeriMenopause• LowP- Sleep,irritability,anxiety,foggy
• Menopause• LowP,E&T- Sleep,irritability,anxiety,depression,flashes,lowlibido,NT’sgodownwhenestrogengoesdown
Hormones
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Copyright,LeslieE.Korn,2020
• Hypothyroid/Hyperthyroid• Cold,depressed/hot,anxious
• Testing&supplementation>referralstoprescribers • Women’sInternationalPharmacy• CompoundingPharmacies
Hormones
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Copyright,LeslieE.Korn,2020
Bioidentical Hormones
Estrogen(s) estrone,estradiol,andestriolProgesterone,Testosterone,DHEA enhancingenergyandmusclestrengthPregnenolone autoimmunedisorders,chronicfatigue,anddepressionThyroidHydrocortisone Fatigue,ResearchsuggestsPTSDpreventionwithin1st3monthshttps://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75
https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75
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Copyright,LeslieE.Korn,2020
Why Test?
•Testingincontext•Clientmaywantit• Itmayimproveadherencetoaplan•Testsmayconfirmwhatwebelieveorsuspect• Illuminatenuances
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• VitaminD–depression,pain,immunefunction• TissueMineralAnalysis(excessmineralsheavymetalscancontributetomentalillness)https://www.traceelements.com/• 24hrdiurnalcortisol•Hormonepanels• Foodsensitivities•DigestivePanels• Specializedtesting:Walshprotocols,B-12,APOEgenetictesting
Laboratory Testing
https://www.traceelements.com/
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•Homocysteine
•High-sensitivityC-reactiveprotein(CRP):norms,under0.55mg/Linmen&under1.0mg/Linwomen
•Fibrinogen:200–300mg/dL
Inflammatory Markers in Blood Tests
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• Simplewaytotestfunctionaldeficiency,commonineatingdisorders
• Takeateaspoonfullofliquidzinc&youwillfindthatyouexperiencevaryingtastesbasedonyourbody’scurrentneeds•Deficientinzinc,theliquidwilltastelikewater•Adequatelevelsitwilltastebitter
Zinc Taste Test
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• Drug–NutrientInteractionsVirtualDatabase• Usethisdatabasetoenteradrugorsupplement;receiveafullinteractionreportthatincludesnoticeofpotentialinteractions.Phone:800-931-17 http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker
Databases
http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checkerhttp://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker
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Lab Testing
108
• TraceElements,Inc.•Hairanalysislaboratory.4501SunbeltDr.,Addison,TX75001 Ph:(800)824-2314.Fax:(972)248-4896 http://www.traceelements.com
•Diagnos-Tech’s,Inc.• Fortestingfoodallergies,adrenalstress,male/femalehormonepanels Ph:(800)878-3787;Email:[email protected]; http://www.diagnostechs.com
http://www.traceelements.commailto:[email protected]://www.diagnostechs.com
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•GlutenandFoodAllergy/FoodSensitivityTesting• CyrexTMspecializesintestingforautoimmuneconditions https://www.cyrexlabs.com/
• GreatPlainsLaboratory• Providesspecializedtesting,includingOrganicAcidstest,Gluten/Casein,VitaminD,aminoacidlevelstesting(urinaryandblood),urinary/serumpeptidetests,&zinctastetest http://www.greatplainslaboratory.com/home/eng/ Tests:https://www.greatplainslaboratory.com/select-a-test-2
Lab Testing
https://www.cyrexlabs.com/http://www.greatplainslaboratory.com/home/eng/https://www.greatplainslaboratory.com/select-a-test-2
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• LifeExtension• Providesrequisitionsforclient-orderedbloodtests http://www.lifeextension.com/Vitamins-Supplements/Blood-Tests
• TheMediatorReleaseTest•Testsforfood&food-chemical-inducedinflammation https://nowleap.com/the-patented-mediator-release-test-mrt/
Lab Testing
http://www.lifeextension.com/Vitamins-Supplements/Blood-Testshttp://www.lifeextension.com/Vitamins-Supplements/Blood-Testshttps://nowleap.com/the-patented-mediator-release-test-mrt/
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• SpectraCell• Providesnutritionaltesting,includingMTHFR,telomeretesting,micronutrienttests(blood),andnutrientstatusforphysicians&theirclients.SpectraCellLabsalsoconductstelomeretestingviabloodsamplesubmission. http://www.spectracell.com/
Lab Testing
http://www.spectracell.com/
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Copyright,LeslieE.Korn,2020
Omega 3 Index
•MeasureslevelsofEPA/DHAinthebloodcell• Bloodspot/athometest• https://omegaquant.com/about/
• https://omegaquant.com/omega-3-calculator/• Calculateshowmuchdoseisneededfollowingtest
https://omegaquant.com/about/https://omegaquant.com/omega-3-calculator/
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Supplements Sources
113
• BioticsResearchCorporation•QualityNutritionalproducts Ph:(800)636-6913;Fax:(800)863-9613; http://www.bioticsnw.com
•AllergyResearchGroup• Excellentsourceofvitamins,minerals,&glandulars. http://www.allergyresearchgroup.com/
http://www.bioticsnw.com/http://www.allergyresearchgroup.com/
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• CarlsonLabs• Excellentsourceforfishoil http://www.carlsonlabs.com/
• IntegrativeTherapeutics• http://www.integrativepro.com
• FungiPerfecti• Providesmedicinalmushroomsupplementsandproducts. FungiPerfectiLLC,POBox7634,Olympia,WA98507; Phone:(toll-freeinUS&Canada):800-780-9126(local):360-426-9292 [email protected]
Supplements Sources
http://www.carlsonlabs.com/http://www.integrativepro.com/mailto:[email protected]
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•NordicNaturals•High-qualityfishoilcombinationsforallages Website:www.nordicnaturals.com
• StandardProcess• Excellentsourceofchlorophyll&glandulars Website:www.standardprocess.com/home
Supplements Sources
http://www.nordicnaturals.com/http://www.standardprocess.com/home
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• LifeExtension• Providesnutritionalinformation,products,&services. http://www.lef.org/
• LifeExtensionMagazine• AmonthlypublicationoftheLifeExtensionFoundationontopicsofnutrition,hormones,&antiagingsupplements. http://www.lifeextension.com/magazine
• ThorneMetabolicNutrition• Qualitynutritionalsupplements. https://www.thorne.com/
Supplements Sources & Information
http://www.lef.org/http://www.lifeextension.com/magazinehttps://www.thorne.com/
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Databases
• RxISK• Free&independentwebsitewherepatients,doctors,&pharmacistscanresearchprescriptiondrugs&easilyreportadrugsideeffect https://www.rxisk.org
•NutritionData• Detailednutritioninformation,plusuniqueanalysistoolsthattellyoumoreabouthowfoodsaffectyourhealth&makeiteasiertochoosehealthyfoods http://nutritiondata.self.com/
https://www.rxisk.orghttp://nutritiondata.self.com/
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• FullScript:upto35%offhighgradesupplements•Signuphereandadonationismadetothecharity• CWIS“NutrientsforNatives”program
•https://fullscript.com/practitioners/dr-leslie-korn
Distributors
https://fullscript.com/practitioners/dr-leslie-kornhttps://fullscript.com/practitioners/dr-leslie-korn
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• BastyrUniversityNutritionPrograms
• http://www.bastyr.edu/academics/areas-study/study-nutrition
•HealthCoachTrainingProgram
• http://www.integrativenutrition.com/
Nutritional Therapies Training
http://www.bastyr.edu/academics/areas-study/study-nutritionhttp://www.bastyr.edu/academics/areas-study/study-nutritionhttp://www.integrativenutrition.com/http://www.integrativenutrition.com/
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• NationalAssociationofNutritionProfessionals(NANP)https://www.nanp.org/list-of-schools
• NutritionalTherapyPractitionerProgram• https://www.nutritionaltherapy.com
Nutritional Therapies Training
https://www.nanp.org/list-of-schoolshttps://www.nanp.org/list-of-schoolshttps://www.nutritionaltherapy.comhttps://www.nutritionaltherapy.com
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•AmericanNutritionAssociation• https://theana.org/advocate
•Weston-PriceFoundation• http://www.westonaprice.org/
Organizations
https://theana.org/advocatehttps://theana.org/advocatehttp://www.westonaprice.org/http://www.westonaprice.org/
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Copyright,LeslieE.Korn,2020
• Ethical&Legalissuesofuseofnutritionalsupplements• Goals&Dosingofsupplements• Contraindications&Drug/NutrientInteractions• CoreNutrientsforMentalHealth• Water&FatSolubleVitamins;Minerals• Aminoacids&Neurotransmitters• ProtocolsofSpecialNutrients,Vitamins,Minerals&Glandulars• IntegrateBioidenticalHormonesforenhancedefficacy• DevelopingProtocols
Summary
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Thank you!drlesliekorn.com [email protected]
http://drlesliekorn.com/mailto:[email protected]?subject=