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Kidney anatomyKidney anatomy-- reviewreview

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Nephron anatomyNephron anatomy-- reviewreview

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Urine formationUrine formation-- overviewoverview

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GlomerulusGlomerulus

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Net filtration pressueNet filtration pressue

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GFR regulationGFR regulation-- autoregulationautoregulation

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GFR regulationGFR regulation-- hormonalhormonal

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GFR regulationGFR regulation-- neuralneural

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Tubular reabsorptionTubular reabsorption-- blood vesselsblood vessels

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Tubular reabsorptionTubular reabsorption-- PCTPCT

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Tubular reabsorptionTubular reabsorption-- PCTPCT

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Tubular reabsorptionTubular reabsorption-- loop of Henleloop of Henle

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Tubular reabsorptionTubular reabsorption-- DCT and CDDCT and CD

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Tubular secretion of KTubular secretion of K++-- CDCD

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Tubular secretion of HTubular secretion of H++-- PCTPCT

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Body fluid compartmentsBody fluid compartments

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Water gain and lossWater gain and loss

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Mechanism of dehydration stimulationMechanism of dehydration stimulation

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ElectrolytesElectrolytes

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pH scalepH scale

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Maintaining pHMaintaining pH-- renal excretion of Hrenal excretion of H++

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Maintaining pHMaintaining pH-- buffer systemsbuffer systems

CO2 + H2O H2CO3 HCO3- + H+

leftward shift causes CO2 and H2O to be exhaled

rightward shift causes H+ to be buffered by bicarbonate ion and

secreted by the kidney

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Metabolic acidosis and respiratory compensationMetabolic acidosis and respiratory compensation

changes in ventilation compensate for

metabolic induced pH disturbance

changes in kidney secretion of H+ and

reabsorption of HCO3- compensate for

respiratory induced pH disturbances