portal hypertensive polyps, a new entity? -...

2
1130-0108/2016/108/5/279-280 REVISTA ESPAÑOLA DE ENFERMEDADES DIGESTIVAS COPYRIGHT © 2016 ARÁN EDICIONES, S. L. REV ESP ENFERM DIG (Madrid) Vol. 108, N.º 5, pp. 279-280, 2016 PICTURES IN DIGESTIVE PATHOLOGY CASE REPORT We report the case of a 62-year-old woman with a his- tory of liver cirrhosis secondary to autoimmune hepatitis, portal hypertension and coagulopathy. Gastroscopy was performed to discard esophageal varices. In the gastric antrum a multiple polypoid and polylobed lesions were observed, occupying prepyloric region and extending into the pylorus and duodenal bulb (Fig. 1). Ultrasonogra- phy was performed to confirm absence of varices at that level. The larger lesions (8, 10, 12 mm) were removed with snare and thermocoagulation. Hemostasis securi- ty (hemoclips) was placed to reduce the risk of delayed bleeding. Pathological study described gastric hyperplas- tic polyps with edema, vascular congestion and smooth muscle hyperplasia without dysplasia or adenomatous changes (Fig. 2). DISCUSSION Portal hypertensive polyps (PHP) are a recent entity, described in cirrhotic patients with portal hypertension, portal venous obstruction or antral vascular ectasia. These lesions are similar to hyperplastic polyps, but with subepithelial vascular alterations histological features. Its prevalence ranges from 1-3% (1,2). The pathogen- ic mechanism is unknown, but is believed to be due to increased gastric angiogenesis (3). Endoscopic image may suggest malignant lesions such as gastric adeno- carcinoma, even submucosal tumor lesions. Usually asymptomatic, but in rare cases, they can cause anemia, gastrointestinal bleeding and gastric outlet obstruction, due to their antral location (4). Some authors recommend a similar management to that of hyperplastic polyps with endoscopic follow-up of asymptomatic, avoiding the complications of polypectomy (2,4). Because the risk of malignant transformation is unknown, some authors recommend resection of the ones over 5 mm (2,5). Com- plications of endoscopic resection are frequent bleeds and perforations (4). Portal hypertensive polyps, a new entity? Verónica Martín-Domínguez 1 , Ariel Díaz-Menéndez 2 , Cecilio Santander 1 and Luisa C. García-Buey 1 1 Department of Gastroenterology. CIBEREHD. IIS-IP. Autonomous University of Madrid. 2 Department of Pathology. Hospital Universitario de La Princesa (HULP). Madrid, Spain Fig. 1. Endoscopic image of polypoid-pseudotumoral in antrum and pre-pyloric region, extending to the pylorus. Fig. 2. Polypoid lesion with elongated foveolar epithelium with hyper- plastic areas and dilated glandular structures. In lamina propria, a nons- pecific acute and chronic inflammatory infiltrate is seen, with moderate edema, numerous congestive vessels and smooth muscle hyperplasia.

Upload: others

Post on 17-Mar-2020

0 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Portal hypertensive polyps, a new entity? - ISCIIIscielo.isciii.es/pdf/diges/v108n5/imagenes1.pdfCASE REPORT We report the case of a 62-year-old woman with a his-tory of liver cirrhosis

1130-0108/2016/108/5/279-280Revista española de enfeRmedades digestivasCopyRight © 2016 aRán ediCiones, s. l.

Rev esp enfeRm dig (Madrid)Vol. 108, N.º 5, pp. 279-280, 2016

PICTURES IN DIGESTIVE PATHOLOGY

CASE REPORT

We report the case of a 62-year-old woman with a his-tory of liver cirrhosis secondary to autoimmune hepatitis, portal hypertension and coagulopathy. Gastroscopy was performed to discard esophageal varices. In the gastric antrum a multiple polypoid and polylobed lesions were observed, occupying prepyloric region and extending into the pylorus and duodenal bulb (Fig. 1). Ultrasonogra-phy was performed to confirm absence of varices at that level. The larger lesions (8, 10, 12 mm) were removed with snare and thermocoagulation. Hemostasis securi-ty (hemoclips) was placed to reduce the risk of delayed bleeding. Pathological study described gastric hyperplas-tic polyps with edema, vascular congestion and smooth muscle hyperplasia without dysplasia or adenomatous changes (Fig. 2).

DISCUSSION

Portal hypertensive polyps (PHP) are a recent entity, described in cirrhotic patients with portal hypertension, portal venous obstruction or antral vascular ectasia. These lesions are similar to hyperplastic polyps, but with subepithelial vascular alterations histological features. Its prevalence ranges from 1-3% (1,2). The pathogen-ic mechanism is unknown, but is believed to be due to increased gastric angiogenesis (3). Endoscopic image may suggest malignant lesions such as gastric adeno-carcinoma, even submucosal tumor lesions. Usually asymptomatic, but in rare cases, they can cause anemia, gastrointestinal bleeding and gastric outlet obstruction, due to their antral location (4). Some authors recommend a similar management to that of hyperplastic polyps with endoscopic follow-up of asymptomatic, avoiding the complications of polypectomy (2,4). Because the risk of malignant transformation is unknown, some authors recommend resection of the ones over 5 mm (2,5). Com-plications of endoscopic resection are frequent bleeds and perforations (4).

Portal hypertensive polyps, a new entity?Verónica Martín-Domínguez1, Ariel Díaz-Menéndez2, Cecilio Santander1 and Luisa C. García-Buey1

1Department of Gastroenterology. CIBEREHD. IIS-IP. Autonomous University of Madrid. 2Department of Pathology. Hospital Universitario de La Princesa (HULP). Madrid, Spain

Fig. 1. Endoscopic image of polypoid-pseudotumoral in antrum and pre-pyloric region, extending to the pylorus.

Fig. 2. Polypoid lesion with elongated foveolar epithelium with hyper-plastic areas and dilated glandular structures. In lamina propria, a nons-pecific acute and chronic inflammatory infiltrate is seen, with moderate edema, numerous congestive vessels and smooth muscle hyperplasia.

Page 2: Portal hypertensive polyps, a new entity? - ISCIIIscielo.isciii.es/pdf/diges/v108n5/imagenes1.pdfCASE REPORT We report the case of a 62-year-old woman with a his-tory of liver cirrhosis

280 V. MARTÍN-DOMÍNGUEZ ET AL. Rev esp enfeRm Dig (maDRiD)

Rev esp enfeRm Dig 2016; 108 (5): 279-280

3. Amarapurkar AD, Amarapurkar D, Choksi M, et al. Portal hyperten-sive polyps: Distinct entity. Indian J Gastroenterol 2013;32:195-9. DOI: 10.1007/s12664-013-0324-3

4. Aydin I, Ozer E, Rakici H, et al. Antral hyperplastic polyp: A rare cause of gastric outlet obstruction. Int J Surg Case Rep 2014;5:287-9. DOI: 10.1016/j.ijscr.2014.03.016

5. Muchldorfer SM, Stolte M, Martus P, et al. Diagnostic accuracy of forceps biopsy versus polypectomy for gastric polyps: A prospective multicentre study. Gut 2002;50:465-70. DOI: 10.1136/gut.50.4.465

REFERENCES

1. Lam MC, Tha S, Owen D, et al. Gastric polyps in patients with por-tal hypertension. Eur J Gastroenterol Hepatol 2011;23:1245-9. DOI: 10.1097/MEG.0b013e32834c15cf

2. Pai CG. Portal hypertensive polyp - what is in a name? Indian J Gas-troenterol 2013;32:163-4. DOI: 10.1007/s12664-013-0331-4. DOI: 10.1007/s12664-013-0331-4