pre-operative cardiovascular evaluation and related imaging€¦ · pre-operative cardiovascular...
TRANSCRIPT
Ivan Anderson, MDRIHVH Cardiology
Pre-Operative Cardiovascular Evaluation
and Related Imaging
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Lee A. Fleisher et al. JACC 2014;64:e77-e137
General Algorithm
Step by Step
• Step 1: Is surgery Emergent?– If Yes, go to surgery– If No, go to Step 2
Step by Step
• Step 2: Is the patient having a heart attack (i.e. ACS, Acute Coronary Syndrome)?– If Yes, treat ACS (see slides
from my NSTEMI lecture)– If No, go to Step 3
• MACE = Major Adverse Cardiac event• GDMT = Guideline Directed Medical
Treatment
Step by Step
• Step 3: Divide patients based on risk of adverse cardiac event (MI, CVA)– Low risk is defined as <
1% – High risk > 1%
• MACE = Major Adverse Cardiac event
• GDMT = Guideline Directed Medical Treatment
High Risk Conditions
• Congestive heart failure• Severe Aortic Stenosis• Severe Mitral Stenosis• Pulmonary Hypertension• Left Main Disease or triple vessel coronary
artery disease• Ventricular tachycardia or defibrillator
Specifics of High Risk Conditions: CHF
• CHF: Guidelines cite retrospective study demonstrating risk of death with CHF and atrial fibrillation, 30-day risk of death was – 9.3% with non-ischemic CHF– 9.2% with ischemic CHF– 6.4% with atrial fibrillation– 2.9% with CAD and no clinical diagnosis of of CHF
• You can consider checking a BNP to refine risk (> 116 pg/mL is elevated by meta-analysis)
• CHF = congestive heart failure, BNP = brain natriuretic peptide
Circulation. 2011;124:289–96J Am Coll Cardiol. 2011;58:522–9.
Specifics of High Risk Conditions: Valvular Heart Disease
• In general, regurgitation is better hemodynamically tolerated than stenosis
• Guidelines: say check echo for suspected moderate or greater valve disease (stenosis or regurgitation)
J Am Coll Cardiol. 2014;64: e77-137
Specifics of High Risk Conditions: Valvular Heart Disease
• Severe Aortic Stenosis: – Traditionally considered high cardiac risk, new guidelines
say surgery is ok with cardiac anesthesia– Study cited quotes a 2.1% 30-day risk of death with
moderate aortic stenosis– My advice: fix the valve first
• Severe Mitral Stenosis– Replace valve or do balloon commissurotomy first if
possible– Can consider surgery if valve repair is not an option– My advice: fix the valve, proceed with extreme caution
Am J Med. 2013;126:529–35
More High Risk Conditions
• Severe Mitral Regurgitation – acceptable risk if asymptomatic
• Severe Aortic Regurgitation – acceptable risk if normal left ventricular ejection fraction
• Untreated sustained or symptomatic ventricular tachycardia – refer to cardiology and arrange for ICD implantation
• ICD or pacemaker present: have representative available or discuss with anesthesia
J Am Coll Cardiol. 2014;64: e77-137
More High Risk Conditions
• Pulmonary hypertension– Risk of peri-operative death 4-26% by cited
studies in the guidelines
• Adult congenital heart disease (ACHD): highest risk is prior Fontan procedure, cyanotic ACHD, pulmonary hypertension, heart failure and significant dysrhythmia
J Am Coll Cardiol. 2014;64: e77-137
Risk Calculators• Revised Cardiac Risk Index (RCRI)
– https://www.mdcalc.com/revised-cardiac-risk-index-pre-operative-risk
• American College of Surgeons NSQIP MICA – National Surgical Quality Improvement Program
Myocardial Infarction Cardiac Arrest– http://www.surgicalriskcalculator.com/miorcardiacarrest
• American College of Surgeons NSQIP Surgical Risk Calculator– NSQIP again is National Surgical Quality Improvement
Program– www.riskcalculator.facs.org
Surgeries by Risk (of Cardiovascular Event)
• Low Risk Surgeries– Ophthalmologic– Plastic Surgery
• Highest Risk– Open heart surgery– Vascular surgery
• Anorectal• Bariatric• Brain• Breast• ENT• Foregut/hepatopancreatobiliary• Gallbladder/adrenal/appendix/• spleen• Intestinal• Neck• Obstetric/gynecological• Orthopedic• Other abdomen• Peripheral vascular• Skin• Spine• Thoracic• Vein• Urologic
Step by Step
• Step 4: Low risk patients, pretty easy
Step by Step
• Step 5: Higher risk patients– Can the do 4 METs?
• Yes, go to surgery• No, go to step 6
Step by Step: Steps 6 and 7
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Outline• General algorithm• High risk conditions
– Severe Aortic Stenosis (avoid)– Severe Mitral Stenosis (avoid)– Pulmonary Hypertension (avoid or optimize)– Ventricular tachycardia or Defibrillator (optimize)– Congestive heart failure (optimize)– Left Main Disease or triple vessel coronary artery disease
(optimize or revascularize)• Prior Cardiac stents• Specific testing• Medical management in the peri-operative setting
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Lee A. Fleisher et al. JACC 2014;64:e77-e137
Stents Algorithm
• Step 1: Were the stents put in less than 6 weeks ago?– Is the surgery elective?
• If yes, then delay for 1 year after drug-eluting stents or 30 days after bare metal stents
• If no, then keep on dual antiplatelet therapy unless risk of bleeding is greater than risk of stent thrombosis
Stents Algorithm
• Step 2: Were the stents put in > 6 weeks ago, but < 1 year ago?– Is the risk of delaying surgery greater than the risk of
stent thrombosis?• If yes, then delay for 6 months• If no, then delay for 1 year
• Step 3: Are stents over 1 year old and the patient is still on dual antiplatelet therapy (DAPT)?– Guidelines say keep DAPT if possible – I say why are they on it? Probably can safely stop
Plavix/Brilinta/Effient
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Outline• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing
– EKG– Echocardiogram (or other assessment of LV function e.g. MUGA)– Exercise stress test– Pharmacologic nuclear– Cardiopulmonary Exercise Testing– Cardiac catheterization
• Medical management in the peri-operative setting
Testing in Pre-Operative Cardiovascular Evaluation
• Specific testing– EKG
• Do for everyone going for any surgery that is not low risk– Echocardiogram (or other assessment of LV function
e.g. MUGA)• Do for dyspnea, known cardiac conditions (CHF, CAD,
arrhythmia, valvular disease)– Exercise stress test
• Cardiopulmonary Exercise testing may be considered in anyone undergoing high-risk surgery
• Exercise stress test (treadmill nuclear, exercise stress echocardiogram) may be considered in anyone undergoing intermediate or higher risk
Testing in Pre-Operative Cardiovascular Evaluation
• Specific testing– Pharmacologic nuclear
• Consider if elevated patient specific risk and poor functional capacity (can’t run)
– Cardiac catheterization• Do not do routinely, only if other tests are abnormal
– Coronary calcium score: I recommend as the initial screening test of choice
Outline
• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
setting
Outline• General algorithm• High risk conditions• Prior Cardiac stents• Specific testing• Medical management in the peri-operative
– Beta Blockers– Statins– ACE-Inhibitors– Alpha-2 agonists– Anti-platelet therapy– Calcium Channel blockers
Medical Management in the Peri-Operative Setting
– Beta Blockers• If they are on them, don’t stop them• If surgery is intermediate- to high-risk consider starting them• If the patient has > 2 risk factors for adverse cardiovascular
outcome (by RCRI calculator) then consider starting• Start them more than 1 day before surgery if at all possible
– Statins• Continue them if they are on them• Consider if vascular surgery• Consider if 1 or more risk factor for adverse outcome
J Am Coll Cardiol. 2014;64: e77-137
Medical Management in the Peri-Operative Setting
– ACE-Inhibitors• Try to keep them on it during the peri-operative setting• If they need to stop, restart as soon as safely possible
– Alpha-2 agonists• Not useful, don’t start to prevent an event
– Anti-platelet therapy• See section on stents• Don’t start aspirin before surgery to prevent events
– Calcium Channel blockers• Diltiazem seems to prevents events (reduces ischemia), but
may precipitate a CHF exacerbation• All others don’t help (e.g. verapamil, amlodipine, felodipine,
etc.)
J Am Coll Cardiol. 2014;64: e77-137
CARP Trial• Randomized Control Trial of revascularization before
elective vascular surgery• Patient population: 5859 patients were recruited from 18
VA hospitals who were scheduled for surgical revascularization/repair of an abdominal aortic aneurysm or bypass of PAD from 1999 to 2003. They had to have at least 1 70% stenosis on cardiac catheterization.
• 80% of patients were excluded for a final study population of 1654
• About 30% of patients had 3-V CAD, 15% with prior CABG• Randomized to stents or no stents (about 10% cross-over)
N Engl J Med 2004;351:2795-804
McFalls EO et al. N Engl J Med 2004;351:2795-2804.
Outcomes, CARP Trial
Predictive Accuracy of Non-Invasive Imaging – EVINCI Study
Circ Cardiovasc Imaging.2015;8:e002179
Patients Were Evaluated with
• Coronary Calcium Scan• Nuclear Stress Test (PET or SPECT)• Exercise Stress Echocardiogram• Cardiac MRI• Cardiac Catheterization +/- Fractional Flow
Reserve (FFR)
• SPECT = Single Photon Emission Computed Tomography• PET = Positron Emission Tomography
EVINCI Study Results
Circ Cardiovasc Imaging.2015;8:e002179
EVINCI Study Results
Circ Cardiovasc Imaging.2015;8:e002179
Questions