td avian influenza

7/21/2019 TD Avian Influenza

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FLU BURUNGAVIAN INFLUENZA

Pada Perkuliahan Mahasiswa Semester 3 !

Ilmu "e#erawatan02/16/15

1T_Disease/NK/STIKMA


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A$ian In%uen&a

'e(niti)ns* E#idemi+,-he )++urren+e ). +ases ). an

illness in a +)mmunit/ )r re0i)n whi+h is in

e1+ess ). the num2er ). +ases n)rmall/e1#e+ted .)r that disease in that area atthat time

Pandemi+,An e#idemi+ that strikes a $er/

wide area4 usuall/ hemis#here5wide )rw)rld5wide

02/16/15

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T_Disease/NK/STIKMA


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A$ian In%uen&a

-hree in%uen&a #andemi+s durin0 thelast +entur/* 6789 :;3N :;


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02/16/15T_Disease/NK/STIKMA

4

1920 1940 1960 1980 2000

H1N1

H2N2

H3N2

1918: Spanish Flu 1957: Asian Flu 1968: Hong Kong Flu

20-40 million deaths 1-4 milliondeaths
http://www.i-s-b.org/wissen/broschuere/32.gif


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A$ian In%uen&a

A$ian in%uen&a is+auses 2/ the;!N6 in%uen&a

$irus In%uen&a A $irus

02/16/15 5T_Disease/NK/STIKMA


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A$ian In%uen&a

A$ian in%uen&a ;!N6* S#)radi+ transmissi)n t) humans in


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A$ian In%uen&a

;i0hl/5#ath)0eni+N!;6 in%uen&a$irus n)w endemi+

am)n0 2ird and#)ultr/ #)#ulati)nsin Asia



8/50

A$ian In%uen&a

S#)radi+ transmissi)n .r)m 2irds t)humans ). ;!N6 raises +)n+erns* ;!N6 ma/ mutate

;!N6 ma/ +)m2ine with 0eneti+ material .r)mhuman in%uen&a $irus +reatin0 a new strain+a#a2le ). human5t)5human transmissi)n and#)tential #andemi+

; des+ri2es the ;!N6 as a C#u2li+health +risisD and de+lared that the w)rldis as +l)se as e$er t) the ne1t #andemi+

02/16/15

8

T_Disease/NK/STIKMA


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A$ian In%uen&a

Aian !" !#man !2

!#man !"

$ol#tion o% 1968 !"N2 In%l#en&a 'andemi(02/16/15 9T_Disease/NK/STIKMA


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A$ian In%uen&a

Virus* Ultrami+r)s+)#i+

in.e+ti)us a0ent thatre#li+ates its sel.

)nl/ within +ells ).li$in0 h)sts

Man/ are#ath)0eni+

A #ie+e ). nu+lei+a+id :'NA )r RNA=wra##ed in a thin+)at ). #r)tein



11/50

A$ian In%uen&a

In%uen&a $irusesare RNA $iruses

Se0mented

0en)me thus0reat anti0eni+di$ersit/



12/50

A$ian In%uen&a

In%uen&a $irus +lassi(+ati)ns* )re #r)tein*

A

B

S#e+ies ). )ri0in :swine4 a$ian4 et+=

Ge)0ra#hi+ site ). is)lati)n

Serial Num2er

Gl/+)#r)tein su2t/#es :In%uen&a A )nl/=

02/16/15

12

T_Disease/NK/STIKMA


13/50

A$ian In%uen&a

-w) ma)r anti0eni+0l/+)#r)teins

em2edded inmem2rane* ;ema00lutinin :;A=

Neuramidase :NA=

Indu+e anti2)d/res#)nse inhumans



14/50

A$ian In%uen&a

A$ian in%uen&a* 68 ;A su2t/#es

7 NA su2t/#es

Man/ su2t/#es#)ssi2le

All su2t/#es .)und in2irds



15/50

A$ianIn%uen&a In%uen&a A*

Res#)nsi2le .)r .reuent:usuall/ annuall/=)ut2reaks )r e#idemi+s). $ar/in0 intensit/

++asi)nal #andemi+s Su2t/#es +ir+ulatin0*

;6N6 N6N< ;3N strains +a#a2le ). e$)l$in0 int)

hi0hl/ #ath)0eni+ strains4

Re+ent ;! $irus strains in+reasin0l/#ath)0eni+

Virulen+e related t) ;A m)le+ules

02/16/15

33

T_Disease/NK/STIKMA


34/50

A$ian In%uen&a

lini+al Features ;!N6*

677>*

9 ). 69 O 6< /ears )ld All 2ut )ne had mild disease

6< /ears )ld Fe$er :6??J= U##er res#irat)r/ tra+t s/m#t)ms :8>J= Pneum)nia :!9J= GI s/m#t)ms :!?J=

02/16/15

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T_Disease/NK/STIKMA


35/50

A$ian In%uen&a

lini+al Features ;!N6*

677>* Risk .a+t)rs

lder a0e 'ela/ed admissi)n t) h)s#ital Pneum)nia Leuk)#enia L/m#h)#enia

)m#li+ati)ns M'S

Renal .ailure ardia+ +)m#r)mise Pulm)nar/ hem)rrha0e Pneum)th)ra1 Pan+/t)#enia

02/16/15

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T_Disease/NK/STIKMA


36/50

A$ian In%uen&a

Primar/ +ause ).death is res#irat)r/.ailure



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A$ian In%uen&a

lini+al .eatures ;!N6


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A$ian In%uen&a

lini+al .eatures ;!N6

In+u2ati)n #eri)d )nun+ti$itis

;!N< hildren sh)w mild4 limited URI s/m#t)ms

02/16/15

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T_Disease/NK/STIKMA


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A$ian In%uen&a

'ia0n)sis Viral +ulture

P)l/merase hair Rea+ti)n :PR= assa/ .)r

a$ian in%uen&a A :;!N6= RNA Immun)%u)res+en+e .)r anti0en with use ).

;! m)n)+l)nal anti2)d/

F)ur5.)ld rise in ;!5s#e+i(+ anti2)d/

02/16/15

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T_Disease/NK/STIKMA


40/50

A$ian In%uen&a

h) sh)uld 2e tested ;i0h5risk #atients

Patients with a hist)r/ ). tra$el within 6? da/s

). s/m#t)m inset t) a +)untr/ withd)+umented ;!N6 a$ian in%uen&a in #)ultr/and)r humans

AN'

Patients with #neum)nia )n AR'S4 )r )therse$ere res#irat)r/ illness .)r whi+h an eti)l)0/has n)t 2een esta2lished

02/16/15

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T_Disease/NK/STIKMA


41/50

A$ian In%uen&a

h) sh)uld 2e tested L)w5risk #atients

Patients with hist)r/ ). +)nta+t with d)mesti+ #)ultr/)r a kn)wn )r sus#e+ted human +ase in an ;!N65

in.e+ted +)untr/ within 6? da/s ). s/m#t)m )nset AN'

')+umented .e$er Q39

AN'

ne )r m)re ). the .)ll)win0* )u0h

S)re thr)at

Sh)rtness ). 2reath

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T_Disease/NK/STIKMA


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A$ian In%uen&a

Va++inati)n N) li+ensed $a++ine

Area ). intense resear+h

Bi)se+ure .a+ilities

reuired 2e+ause ). $iral#ath)0eni+it/

Viruses are lethal t)e00s whi+h #re$entsmass $a++ine

#r)du+ti)n A$ian $a++ines a$aila2le

alth)u0h in+)nsistentl/administered



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02/16/15 T_Disease/NK/STIKMA 43


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A$ian In%uen&a

-reatment Ee+ti$e dru0s*

M< +hannel 2l)+kers

Amantadine :S/mmetrel= Rimantadine :Flumadine=

Neuraminidase inhi2it)rs seltami$ir :-ami%u=

Zanami$ir :Relen&a=

02/16/15

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T_Disease/NK/STIKMA


45/50

A$ian In%uen&a

-reatment ;!N6 in -hailand has de$el)#ed mutati)ns in

the M< #r)tein whi+h makes it resistant t)amantadine and rimantadine :neuraminidaseinhi2it)rs remain ee+ti$e=

seltami$ir :-ami%u= ee+ti$e when 0i$en earlyin the +)urse ). the in.e+ti)n

seltami$ir :-ami%u= inee+ti$e when 0i$enlatein the +)urse ). the in.e+ti)n

-reat .)r !59 da/s

02/16/15

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T_Disease/NK/STIKMA


46/50

A$ian In%uen&a

Pre$enti)n P)ultr/ )ut2reak*

Tuarantine 'e#)#ulati)n Area sur$eillan+e

)rkers* PPE :0)wns4 0l)$es4 .reuent hand washin0= N7! mask Pr)#h/la1is Va++inati)n with +urrent in%uen&a $a++ine

02/16/15

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T_Disease/NK/STIKMA


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A$ian In%uen&a

P)st5E1#)sure Pr)#h/la1is ;)useh)ld +)nta+ts ). ;!N6 #atients

sh)uld re+ei$e )seltami$ir dail/ .)r >56?

da/s M)nit)r tem#erature

Tuarantine

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T_Disease/NK/STIKMA


48/50

A$ian In%uen&a

02/16/15

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T_Disease/NK/STIKMA


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Sem)0aBerman.aat

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td avian influenza

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