U01 Project Presentation: MSMof primary motor cortex (M1)

Bill Lytton

Gordon Shepherd

SUNY Downstate, Kings County Hospital, Northwestern University

Mar 2, 2015 15:00

Multiscale modelingScales of investigation

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 2 / 23

MSM Neurotechnologies

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 3 / 23

Neurotechnologydynamical fitting (cell and net, CNR)large networks (HPC technology, Yale)Databasing and data-mining (Yale, UCL)Future: down to RxD; up to multi-area

Neural dynamics and codingSignal transforms (sensorimotor transforms)“Packets” via δθαβγMultiplicity of codes

Neurobiology of disease and treatmentAutismBMISchizophrenia

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 4 / 23

Moving away from Frankensteinnetworks

1 species

1 age range

1 lab

1 set of techniques

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Interactions between levelsBipartite output/STR-SPI code transformation hypothesis

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Complex parameterizations:voltage-sensitive ion channel level

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Pyramidal neuron model complexity

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Fitting different aspects

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Praxis (principal axis method)

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 10 / 23

Neural Dynamics and coding

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A century of layers

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Cell layout: ‘y-fraction’

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Betweenness centrality viewnodes present in higher proportion of shortest paths

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 14 / 23

Dynamics of a networkNeed to improve LFP generation

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 15 / 23

Machine learning for biomimesis2-stage learning EA then STDP

Lytton (DMC,NW) NeuroSimLab.org Mar 2, 2015 15:00 16 / 23

Multiplexing of multicodesLikely many codes coexist

Rate code (Adrian)

First-wave code (Thorpe)

Synchrony code (Singer)

Phase code (Lisman)

Point attractors (Hopfield)

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Cross frequency relationsReality on L (rat L medial PFC)

frequency (Hz)

freq

uen

cy (

Hz)

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NEURON simulation environment

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ModelDB: Simulation databasing

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NEUROML/Open Source Brain

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BRAIN, HBP/BBB, ABIBrain research through advancing innovative neurotechnologies

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