association between glycemic-1
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Association Between GlycemicControl and Morning Blood
Pressure Surge With VascularEndothelial Dysfunction in
Tye !
Dia"etic PatientsKoichiro Yoda, Masaaki Inaba,
Kae Hamamoto, Maki Yoda,
Akihiro Tsuda,Katsuhito Mori,Shinsuke Yamada, Masanori Emoto,
Hidenori Koyama, and Yasuo Imanishi
Diabetes Care Volume !, March
"#$%
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Patients with DM tend to e#hi"it
accelerated arteriosclerosis and areconse$uently at higher ris% of cardio&asculardisease including stro%e and coronary heartdisease'
(t is ossi"le that inade$uate glycemic
control or the occurrence of insulinresistance acti&ate symathetic acti&ity)which leads to MBPS in DM atients'
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*B+ECT(VE
e&aluate the association ,
insulin resistance + glycemic controlwith Morning Blood Pressure Surge-
association "etween,
MBPSand vascular endothelial
dysfunction) as assessed "yendothelium.deendent /MD and 0MD inT!DM atients'
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1ESEA1C2DES(G0 A0DMET2*DS
34 atients with T!DM-
E#clusion criteria,
renal dysfunction 56eG/17894 m:;min;
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!@ h am"ulatory "lood ressuremonitoring-
Assessed the &ascular function "y,
"rachial arterty ow mediated dilaton5/MD?-
nitroglycerin.mediated dilaton 50MD?'
1ESEA1C2 DES(G0 A0D
MET2*DS
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1ES:TS
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Multi&ariate Association of theClinical Varia"le With MBPS in T!DM
Patients
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Multi&ariate Association of MBPS With/MD) "ut 0ot 0MD in T!DM Patients
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C*0C:S(*0S
:imitations ,
cross .sectional study
insucient to disentangle otentionalrelationshis among oor glycemiccontrol) insulin resistance) and MBPS
5"ecause 2"A
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:imitations,
DM atients enrolled in the study weretreated with &arious drugs) includingantihyertensi&e drugsand statins) theeect of those treatments on MBPScould not "e totally negated
C*0C:S(*0S
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poor glycemic control and insulinresistance are indeendentlyassociated with the occurrence of
MBPSin T!DM atients) which might"e signiFcantly associated withendothelial dysfunction'
C*0C:S(*0S
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TAE 2*ME MESSAGE
Morning Blood Pressure Surge might"e one of the maHor targets forre&enting &ascular damage in T!DMatients'
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T2A0 I*J