The circadian clock plays a role not just

in sleep wake cycles but also in the

regulation of metabolic systems.

circadian misalignment

Circadian misalignment has been linked

to a number of negative health

problems.

Individuals who work night shifts suffer

severe circadian misalignment

Impaired glucose tolerance and

circadian misalignment

Animal experiments

Circadian misalignment impaired energy metabolism

Type 2 diabetes (T2D) & bed times

Evening types & breakfast skipping

Social Jetlag

BMI & social jetlag

AIMS:

To investigate if chronotype is

independently associated with

Glycaemic control in T2D

Examine the relationship between daily

calorific intake and Glycaemic control

194 Adults TD2

Height, Weight, medications & HbA1c levels

PSQI, MSF, Berlin questionnaire &CES-D

Midsleep time weekdays

Midsleep time freedays

= Social Jetlag

Table 2: Chronotype and Glycaemic Control

HbA1c levels tended to be higher in

those with social jetlag >30mins though

was not significant

There was a small positive correlation

between dinner calorie intake and

HbA1c levels (r = 0.26, p= <.0001)

There was a medium positive correlation

between chronotype and Glycaemic

control (r = 0.34, p<.0001)

Multiple regression was carried out – controlling for

gender, race, BMI, insulin use, diabetic

complications & perceived sleep debt.

Results indicated that chronotype was

independently associated with Glycaemic control

(B = .025, p=000.1)

For each hour delay in MSF there was a 2.5%

increase in HbA1c levels

Both MSF and calorific intake at dinnertime were

significantly associated with HbA1c levels.

Chronotype is associated with Glycaemic control in T2D

This association is independent of sleep debt, perceived sleep debt and poor sleep quality

Results also indicated that later chronotypeswere found to be both significantly younger and report more depressive symptoms