Bio-based chemistry is penetrating all market seg-ments and is promoted more and more to consum-ers of fi nal products. Cosmetic and beauty care are industries where this trend is strongly growing and provides challenges to the key players to develop new formulations in line with consumer demands. New formulations mean new ingredients with a stronger sustainable approach for the production of the raw material and the fi nal products. Minasolve® is help-ing in such achievement by proposing bio-ingredi-ents developed under green chemistry principles to cope with market demands and customer focus. One of the key ingredients developed for this market seg-ment is A-Leen 5 (INCI name Pentylene Glycol) which has been developed and produced with a proprietary process established by Minasolve®’s sister company Pennakem, specialized in furfural chemistry. This bio-based ingredient has now proven its versatility in its use in cosmetic formulations and brings multiple prop-erties to the fi nal products. This bio-based ingredient, odourless, GMO free, fi rst of its kind in the 1,2-alkan-ediol range, has been awarded the silver award for Green Ingredients at in-cosmetics 2014 in Hamburg.

A particular challenge of today is the cost-effective production of self-preserved cosmetic products for the mass-market. In order to meet this demand, Minasolve offers now three cost-optimized and easy to use solutions: EasySafe P8, EasySafe GC 8 and EasySafe OC 8. Each of these ingredients is based on safe, mild and undisputed components, all three of them being effective at low dosage. Together these novel ingredients provide a versatile tool-box to the formulator, helping to meet the latest market expectations in terms of safety and “clean labelling”.

From Biomass to COSMETIC Sustainable

Multifunctional Ingredients and

Solutions.

Today’s general environmental and human safety con-cerns, associated with the growing global trend for sustainable production, have led to more and more interest in the development of high value ingredients in accordance with the principles of green chemistry.

Pennakem, which has been active in renewable chem-istry since the 1940s, and Minasolve®, a sister com-pany in the Minafi n group, have jointly developed a new, effi cient and cost effective process to deliver high volumes of the multifunctional compound, bio-based 1,2-pentanediol (INCI name Pentylene Glycol). Minasolve® is marketing this ingredient under the brand name A-Leen 5 for personal care and other applications.

Pennakem has developed a proprietary green manu-facturing process to produce odourless bio-based 1,2-pentanediol which is based on valorizing the natural waste material sugar cane bagasse and which

uses renewable chemistry to create a high quality cosmetic ingredient.

The growing interest of personal care formulators in using this ingredient is confi rmed by the growth of new product launches during the past few years. According to Mintel, the number of new products containing pentylene glycol has grown from 1000 in 2010 to 1500-1600 in the last three years. Additionally, the number of new products claiming “no parabens’ almost doubled from under 200 in 2010 to nearly 400 last year.

The anti-microbial activity profi le of A-Leen 5 is equiv-alent to its petrochemical-based analogues. The suit-ability of A-Leen 5 as an anti-microbial protection agent for typical cosmetic products has been demon-strated in microbial challenge tests in accordance to ISO 11930 standards.

CONCLUSIONS

The development of an effi cient, green, and cost effective process to produce large volumes of bio-based 1,2-pentanediol results from the trend towards sustainable growth in many different global markets. A key multifunctional ingredient for personal care and cosmetic products has been developed in the quest for safer preservation and sensory improvement sys-tems and to support the growing market demand for

natural ingredients. A-Leen 5 answers customers’ expectations for better environmental respect and social responsibility. It can easily be used to substitute petrochemical-based additives in current cosmetic products and consequently easily improves the natu-ral index of the product. This innovative achievement won the silver Green Ingredients Award at In-Cosmet-ics 2014.

Production

« Pennakem, our US sister company is active in renewable chemistry since the 1940’s »

GREEN CHEMISTRY

BACK INTEGRATED RAW MATERIALS – FULL TRACEABILITY

FURFURAL APPLICATIONS

« Minasolve is the Pioneer of bio-based

Pentylene Glycol»SUGAR CANE BAGASSE

RESPONSIBLE SOURCING

FURFURAL

A-LEEN 5

COSMETIC GRADEODOURLESS

OHOH

FoodPharmaCosmeticsRubberAgro

Furfuryl Alcohol PurifiedO

O

H

2 3

Pennakem, specialized in furfural chemistry. This bio-based ingredient has now proven its versatility in its use in cosmetic formulations and brings multiple prop-erties to the fi nal products. This bio-based ingredient, odourless, GMO free, fi rst of its kind in the 1,2-alkan-ediol range, has been awarded the silver award for Green Ingredients at in-cosmetics 2014 in Hamburg.

A particular challenge of today is the cost-effective production of self-preserved cosmetic products for the mass-market. In order to meet this demand, Minasolve offers now three cost-optimized and easy to use solutions: EasySafe P8, EasySafe GC 8 and EasySafe OC 8. Each of these ingredients is based on safe, mild and undisputed components, all three of them being effective at low dosage. Together these novel ingredients provide a versatile tool-box to the formulator, helping to meet the latest market expectations in terms of safety and “clean labelling”.

2

Green Extraction Solvent Bio-based cosmetic formulations are becoming increasingly popular. The most com-monly used natural ingredients are extracts from plant materials. A key decision in the production of truly sustainable extracts is the choice of the extraction solvent.

A-Leen 5 (INCI name Pentylene Glycol) is a non-volatile hydrophilic/amphiphilic solvent. It can be favorably used as a (co)extraction agent and solvent for herbal ingredients:

► The amphiphilic nature of A-Leen 5 ensures that both polar and non-polar constituents are extracted from plant materials and stabilized inside the extract. The extraction power of A-Leen 5 is comparable to that of ethanol (Figure A/B).

► A-Leen 5 can be easily combined with water as extraction agent, which lowers the vis-cosity and enhances the cost effectiveness. The solubilization properties of A-Leen 5 are largely maintained, even at higher levels of water.

► A-Leen 5 has a relatively low volatility with a boiling point of 206 °C. Extractions at high temperature can be carried out under atmospheric pressure.

► The attractive skin conditioning effects of A-Leen 5 make it possible to add the obtained extracts directly into cosmetic formulations. It is not necessary anymore to remove any ex-traction solvent that is possibly not skin friendly. Energy-intensive solvent exchanges can be omitted.

► Thanks to the antimicrobial activity of A-Leen 5, extracts containing at least 5% of A-Leen 5 are self-preserved. Microorganisms potentially present on vegetal materials are effectively killed, and the extracts are well protected against a re-infestation by microbes.

Figure A Figure B

Figure A highlights the application of A-Leen 5 in comparison with Ethanol as solvent for the extrac-tion of peppermint leaves. For each extraction, 10 g of plant materials were suspended in 50 g of extraction solvent. The mixtures were heated and stirred at 75-80°C for 15 minutes. After cooling, the solid constituents were fi ltered off and the fi ltrates were analyzed by HPLC. In conclusion, A-Leen 5 and Ethanol showed comparable performances as extraction solvents.

Figure B: Qualitative and semi-quantitative HPLC-analysis (UV detection at 254 nm) of Peppermint leave extracts obtained by using A-Leen 5 and Ethanol as extraction agents.

CONCLUSION : A-Leen 5 is an innovative green extraction solvent that enables to in-crease the Natural Origin Index of cosmetic formulations.

Aroma-3INCI: Phenylpropanol

A-Leen Aroma-3 is a nature-derived version of Phenylpropanol, a fragrance component naturally occurring in fl owers and fruits – such as Hyacinths, Narcissus and ripe strawberries.

A-Leen Aroma-3 is a mild perfuming agent. It brings a comfortable, balsamic and spicy oriental note to personal care products.

A-Leen Aroma-3 also shows a broad spectrum anti-microbial activity that helps to protect all kinds of cosmetic products against microbial degrada-tion. This activity is largely pH-independent.

A-Leen Aroma-3 is produced starting from Cas-sia essential oil, which is traditionally obtained by steam distillation from the leaves and branches of the Chinese cinnamon tree Cinnamomum cassia. The full manufacturing process of A-Leen Aroma-3 is in accordance with the principles of “green-chem-istry” and complies with the standards COSMOS and NATRUE.

A-Leen Aroma-3 is free of fragrance allergens and free of listed preservatives.

Green AINCI: Pentylene Glycol, Phenylpropanol

E-Leen Green A is a novel, synergistic combina-tion of nature-based Pentylene Glycol (A-Leen 5) and nature-based Phenylpropanol. The mixture represents a cost-effective solution to obtain com-pletely self-preserving cosmetic products.

Both constituents of E-Leen Green A are produced by means of “green chemistry” and thus meet the requirements of the natural cosmetics standards COSMOS and NATRUE.

E-Leen Green A is skin-moisturizing, skin condition-ing and mildly perfuming. Its antimicrobial effect is largely independent of the pH value.

E-Leen Green A is water-soluble up to 3% and there-fore suitable for clear, water-based products. By combination with Pentylene Glycol, the lipophilic Phenylpropanol remains predominantly in the water phase of emulsions. This circumstance contributes signifi cantly to the broad antimicrobial effect of E-Leen Green A.

A-Leen Aroma-3 & E-Leen Green ATwo universal solutions for natural antimicrobial protection over a large pH range.There is a general and steadily growing demand from consumers for safe, mild and nature-based cosmetics. These products should be self-preserved, as well as free of harsh preservatives and allergens. Minasolve offers two novel solutions to protect these kinds of modern formulations:

Ethanol

A-Leen 5

96% EthanolA-Leen 5

Relative sum of HPLC integrals (%)

0

0 5 10 20 min15

20

40

60

80

100

120

140

4 5

EasySafe P8The alternative for ultimate per-formance

INCI: Caprylyl Glycol, Phenylpropanol

EasySafe P8 provides broad-spectrum protection, also at high pH-values. It combines two multifunctional ingredients: Caprylyl Glycol, a wellknown skin humectant, and Phenylpropanol, an aroma compound naturally occurring in fl owers and fruits. EasySafe P8 is also well suitable for clear, water-based products.

EasySafe GC 8Mild, safe and versatile protec-tion

INCI: Caprylyl Glycol, Glyceryl Caprylate/Caprate, Glycerin

EasySafe GC 8 is designed to protect mild and low-odour for-mulations. It is based on Glyceryl Caprylates and Caprates derived from vegetable oils. These mild skin care agents have refatting and co-emulsifying properties. EasySafe GC 8 has a broad-spec-trum antimicrobial effect. It can also help to avoid thinning effects which may be caused by Caprylyl Glycol in some formula-tions.

EasySafe OC 8The eco-friendly preservative solution

INCI: Caprylyl Glycol, Phenylpropanol, o-Cymen-5-ol

EasySafe OC 8 is an eco-friendly alternative to out-of-time pre-servatives, such as Triclosan or Triclocarban. EasySafe OC 8 combines three mild ingredients, resulting in a powerful antimi-crobial and anti-oxidant activity. Among them is the skin-friendly preservative o-Cymen-5-ol, an isomer of thymol – the active mol-ecule of thyme. EasySafe OC 8 is of low odour and free of halogen-containing compounds. The anti-microbial effect of EasySafe OC 8 is largely pH-independent.

EasySafe P8 / GC 8 / OC 8Three optimized and cost-effective solutions for alternative formula protectionSafety is key in the design of consumer products, regardless of their sales price. Minasolve® therefore offers three new solutions for alternative formula protection. They are based on the cost-effective multifunctional ingredient Octiol (INCI name Caprylyl Glycol). All three solutions are temperature-stable and easy to use liquids.

EasySafe SelectorIn order to simplify the choice of the best ingredient for your project, we have created a simple selection tool. It provides a fi rst recommendation for the most appropriate EasySafe candidate versus pure Octiol, based on specifi c applications and key criteria.

Our Product PortfolioIn 2019, Minasolve will pursue its goal: becoming your key partner for Green Solutions. In order to reach this objective, we are pleased to propose the following range of products

Optimized Performancesolutions

Boosters/Preserva-

tives

Actives

Pure Natural Ingredients, COSMOS

Synergistic Green Solutions, COSMOS

Optimized Performance Solutions

Multifunctional Ingredients

Cosmetic Active Ingredients

A-Leen

E-Leen

EasySafe

Baby care

Body care

pH > 6

Low odour

Rinse-off

Cold process

Mildness

Face care

Best choice

EasySafe P8

EasySafe GC8

EasySafe OC8

Octiol

6 7

INCI ORIGIN ECOCERT COSMOS APPROVED

NATRUE COMPLIANT REGULATORY STATUS DESCRIPTION FORM/ODOUR ANTIMICROBIAL

ACTIVITY PH RANGE RECOMMENDED USE LEVEL FORMULATION GUIDELINES

A-Leen

A-Leen 5 Pentylene Glycol Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Derived-natural emollient & moisturizer. Preservative booster. Extraction solvent & solubilizer. Excipient for gelling agents.

Clear, colourless liquid Odourless

Bacteria, Yeast and Mold (Booster) 3.0 ⊲ 10.0 0.5 ⊲ 5.0%

For optimum efficacy of preservation, it should be added to emulsions at the post-emulsifi-

cation stage.

A-Leen Aroma-3 Phenylpropanol Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Nature-derived perfuming agent with pH-independent antimicro-bial effect. Free of listed preservatives and fragrance allergens.

new 2018Clear, colourless liquid

Characteristic odourBacteria, Yeast and

Mold (Booster) 3.0 ⊲ 10.0 0.5 ⊲ 1.0%

Soluble in water up to 0.5%, miscible with alcohols and polar oils; should be added to

emulsions at the post-emulsification stage for optimum anti-microbial efficacy.

E-Leen

E-Leen Green A Pentylene Glycol, Phenylpropanol Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Non ionic, preservative-free and nature-derived antimicrobial blend. Contains A-Leen 5 and natural origin Phenylpropanol.

new 2018Clear, colourless liquid /

Sweet, floralBacteria, Yeast and

Mold 3.0 ⊲ 10.0 1.0 ⊲ 3.0% Water soluble up to 3%.Suitable for cold and hot processes

E-Leen Green B Pentylene Glycol, Water, Sodium Benzoate, Benzoic Acid Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Anionic broad spectrum antimicrobial, ideal for low pH formula-tions. Contains A-Leen 5

Clear, colourless liquid / Odourless or faint

Bacteria, Yeastand Mold 3.0 ⊲ 6.0 1.0 ⊲ 3.0%

(max. 5%)

Water soluble. Suitable for cold and hot processes.

The lower the pH, the stronger the activity.

E-Leen Green C Pentylene Glycol, Glyceryl Caprylate/Caprate Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Non ionic, preservative-free antimicrobial blend. 100% nature-derived. Contains A-Leen 5.

Clear, colourless liquid/ Odourless or faint

Bacteria, Yeast, Fungistatic against

Mold4.0 ⊲ 7.0 1.0 ⊲ 3.0% Dispersible in water.

Suitable for cold and hot processes.

E-Leen Green OR

Pentylene Glycol, Glycerin, Citrus Aurantium Amara (Bitter Orange) Fruit Extract, Citrus Reticulata (Tangerine) Fruit Extract, Citrus

Aurantium Sinensis (Orange) Peel Extract, Ascorbic Acid, Citric Acid, Lactic Acid

Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Non ionic, multifunctional ingredient with antimicrobial and antioxidant properties. Contains A-Leen 5 & Citrus extracts. Preservative-free, water-soluble and 100% nature-derived.

new 2018

Clear, yellow liquid /Odourless or faint

Bacteria, Yeast and Mold 3.0 ⊲ 6.5 1.0 ⊲ 3.0%

Water soluble.Suitable for cold and hot processes.

Keep product pH <= 6.5

EasySafe

EasySafe Green A Pentylene Glycol, Phenylpropanol Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Non ionic, preservative-free antimicrobial blend.Contains A-Leen 5 and aromatic compound.

Clear, colourless liquid / Sweet, floral

Bacteria, Yeast and Mold 3.0 ⊲ 10.0 1.0 ⊲ 3.0% Water soluble up to 3%.

Suitable for cold and hot processes.

EasySafe Hexam+ Pentylene Glycol, Water, Hexamidine Diisethionate Derived-Natural Europe, USA, Canada, Australia, China, Korea

Boosted liquid form of MinaSolve® Hexam with A-Leen 5.Cationic antimicrobial blend with skin moisturising properties.

For sensitive skin & baby applications.

Clear, colourless liquid / Odourless or faint

Bacteria, Yeastand Mold 3.0 ⊲ 6.5

0.2 ⊲ 2% / max.1.0% eye & oral

care

Water soluble. Suitable for cold and hot processes.

Can be added at any stage of the formulation, as long as the product is kept at pH 3- 6.5.

EasySafe GC 8 new 2019 Caprylyl Glycol, Glyceryl Caprylate/Caprate, Glycerin Derived-natural Europe, USA, Canada, Aus-

tralia, China, Japan, KoreaNature-derived antimicrobial blend - efficient, non-ionic and

preservative-free, for mild and low odour formulations

Clear, colourless or slightly yellow liquid /

Odourless or faint

Bacteria, Yeast and Mold 4.0 ⊲ 7.0 0.5 ⊲ 2.0%

Can be added to aqueous phases containing surfactants, or at the end, e.g. after emulsi-

fication

EasySafe OC 8new 2019 Caprylyl Glycol, Phenylpropanol, o-Cymen-5-ol Non-Natural Europe, USA, Canada, Aus-

tralia, China, Japan, KoreaPreservative blend, boosting the effect of o-Cymen-5-ol, easy to

use liquid, bio-degradable alternative to TriclosanClear, colourless liquid/

faint aromatic odourBacteria, Yeast and

Mold 3.0 ⊲ 8.0 0.5 ⊲ max. 1.5%Can be added to aqueous phases containing surfactants, or at the end, e.g. after emulsi-

fication

 EasySafe P8new 2019 Caprylyl Glycol, Phenylpropanol Non-Natural Europe, USA, Canada, Aus-

tralia, China, Japan, KoreaCost-effective antimicrobial blend based on Octiol, non-ionic and preservative-free, suitable also for high pH, easy to use

Clear, colourless liquid/ faint aromatic odour

Bacteria, Yeast and Mold 3.0 ⊲ 10.0 0.5 ⊲ 1.5%

Can be added to aqueous phases containing surfactants, or at the end, e.g. after emulsi-

fication

INCI ORIGIN ECOCERT COSMOS APPROVED

NATRUE COMPLIANT REGULATORY STATUS DESCRIPTION FORM/ODOUR ANTIMICROBIAL

ACTIVITY PH RANGE RECOMMENDED USE LEVEL FORMULATION GUIDELINES

BOOSTER / PRESERVATIVES

Caprocine Capryloyl Glycine Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Anionic multifunctional ingredient with antimicrobial properties.

White crystallinepowder

Bacteria andMold (weak on

C. albicans)4.0 ⊲ 7.0 0.5 ⊲ - 2.0% Dissolve in hot water or in

cold alkaline water (pH > 7.0).

MinaSolve CapEasy Water, Capryloyl Glycine, Sodium Bicarbonate Derived-natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Self preserved, aqueous solution of Caprocine (~30% a.i.). Multifunctional with antimicrobial properties.

Clear, colourless liquid / Odourless

or faint

Bacteria andMold (weak on

C. albicans)4.0 ⊲ 7.0 1.5 ⊲ 7.0%

Can be added at any stage of the formulation.No heating, premixing, or pH-adjustment

is needed for dissolution.

MinaSolve Hexam Hexamidine Diisethionate Non-Natural Europe, USA, Canada, Australia, China, Korea

Cationic, mild antimicrobial & antiseptic.Recommended for sensitive skin & suitable for baby applica-

tions. ECO-IMPROVED PROCESS

White or slightlyyellow powder

Bacteria, Yeastand Mold 3.0 ⊲ 6.5

0.01 ⊲ 0.1% / max. 0.05% eye

& oral care

Dissolve into the water phase, or make a premix in water or a diol. Keep the pH of the

product at 3- 6.5.

Hexiol 1,2-Hexanediol Non-Natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Emollient & moisturizer. Preservative booster.Also a perfume co-solubiliser and pigment dispersing aid.

Clear, colourless liquidFaint characteristic odour / Odourless for Hexiol EP

Booster 3.0 ⊲ 10.0 0.3 ⊲ 3.0%Can be added either upfront in the water

phase, or once the emulsion has been made and cooled down to < 40°C.

Octiol Caprylyl Glycol Non-Natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea Emollient & moisturizer. Preservative booster. Clear colourless liquid

or low melting waxy solid Booster 3.0 ⊲ 10.0 0.1 ⊲ 1.5%Should be molten at ≥40°C before use.

Limited water solubility; can be dispersed in the aqueous phase.

Pentiol Pentylene Glycol Non-Natural Europe, USA, Canada, Aus-tralia, China, Japan, Korea

Non-natural emollient & moisturizer. Preservative booster. Extraction solvent & solubilizer. Excipient for gelling agents.

Clear, colourless liquidOdourless Booster 3.0 ⊲ 10.0 0.5 ⊲ 5.0%

For optimum efficacy of preservation, it should be added to emulsions at the post-emulsifi-

cation stage.

FORM

ULA

PRO

TECT

ION

BOO

STER

/PRE

SERV

ATIV

ESOur Product Range A-Leen, E-Leen, EasySafe and Boosters/Preservatives

8 9

(1) Quasi-drug registration required

(2) Max recommended use level for a leave-on body application: 0.04%

(3) Max recommended use level for a leave-on body application: 0.1%

ANTI

OXID

ANT

ANTI

-INFL

AMM

ATOR

Y

ANTI

-SEB

UM

DEO

LIGH

TENI

NG

ANTI

-DAN

DRUF

F

ANTI

-AGE

COOL

ING

INCI ORIGIN ECOCERT COSMOS Approved

NATRUE COMPLIANT

REGULATORY STATUS DESCRIPTION FORM/

ODOURANTIMICROBIAL

ACTIVITY PH RANGE RECOMMENDED USE LEVEL FORMULATION GUIDELINES

ACTIVES

Caprocine Capryloyl Glycine DerivedNatural

Europe, USA, Canada, Australia,

China, Japan, Korea

Anionic multifunctional ingredient with antimicrobial properties.

White crystal-line powder

Bacteria and Mold (weak on C.

albicans)4.0 ⊲ 7.0 0.5 ⊲ 2.0% Dissolve in hot water or in cold

alkaline water (pH > 7.0).

MinaSolve CapEasy Water, Capryloyl Glycine, Sodium Bicarbonate

DerivedNatural

Europe, USA, Canada, Australia,

China, Japan, Korea

Self preserved, aqueous solution of Caprocine (~30% a.i.). Multifunctional

with antimicrobial properties.

Clear, colourless

liquid / Odourless

or faint

Bacteria and Mold (weak on C.

albicans)4.0 ⊲ 7.0 1.5 ⊲ 7.0%

Can be added at any stage of the formulation. No heating, premix-

ing, or pH-adjustment is needed for dissolution.

E-Leen Green OR

Pentylene Glycol, Glycerin, Citrus Aurantium Amara

(Bitter Orange) Fruit Extract, Citrus Reticulata (Tangerine) Fruit Extract,

Citrus Aurantium Sinensis (Orange) Peel Extract

DerivedNatural

Europe, USA, Canada, Australia,

China, Japan, Korea

Non ionic, multifunctional ingredient with antimicrobial and antioxidant

properties. Contains A-Leen 5 & Citrus extracts. Preservative-free, water-solu-

ble and 100% nature-derived. new 2018

Clear, yellow liquid

/ Odourless or faint

Bacteria, Yeast and Mold 3.0 ⊲ 6.5 1.0 ⊲ 3.0%

Water soluble. Suitable for cold and hot processes. Keep product

pH <= 6.5

Elage Ellagic Acid DerivedNatural

Europe, USA, Canada, Australia, China, Japan (QD

(1)), Korea

Lightening agent Beige to yel-low powder - 3.0 ⊲ 5.5 0.1 ⊲ 1.0% Disperse in the water phase of an

emulsion.

Fresh’in Methyl Diisopropyl Propionamide Non-Natural

Europe, USA, Canada, Australia,

China, Japan, KoreaRefreshing agent

White crystal-line powder / Fresh odour

- Unlimited 0.04 ⊲ 1.5% (2) Add to the oil phase of the emulsion or solubilise in a diol or alcohol.

Fresh’in Green+ Pentylene Glycol, Methyl Diisopropyl Propionamide

DerivedNatural

Europe, USA, Canada, Australia,

China, Japan, Korea

Refreshing agent, easy to use liquid form

Colourless liquid / Fresh

odour- Unlimited 0.1 ⊲ 2.5% (3) Add at any stage of the formulation,

soluble/dispersible in water.

MinaSolve Hexam Hexamidine Diisethionate Non-naturalEurope, USA,

Canada, Australia, China, Korea

Cationic, mild antimicrobial & antiseptic. Recommended for sensitive

skin & suitable for baby applications. ECO-IMPROVED PROCESS

White or slightly yel-low powder

Bacteria, Yeast and Mold 3.0 ⊲ 6.5

0.01 ⊲ 0.1% / max. 0.05% eye

& oral care

Dissolve into the water phase, or make a premix in water or a diol.

Keep the pH of the product at 3- 6.5.

Resve Resveratrol

Natural (Japanese knotweed / min. 98%)

Europe, USA, Canada, Australia,

China, Japan, KoreaMultifunctional ingredient

Off-white to beige powder / Characteris-

tic odour- 3.0 ⊲ 7.0 0,1 ⊲ 1.0% Lipophilic; soluble in the presence

of PEGs, alcohols.

ACTI

VES

Active Ingredients For your skin care, hair care, make-up & toiletry products, to treat, purify, condition, soothe or refresh !

10 11

Quick decision guide: Antimicrobials & boosters for Skin Care, Hair Care, Toiletries & Make-up

The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-tions dealing with manufacture, composition, local procedures, product design, or end usage.

E-Leen SelectorComparison of blends based on A-Leen 5 (Pentylene Glycol):

E-Leen Green A Pentylene Glycol, Phenylpropanol

E-Leen Green B Pentylene Glycol, Water, Sodium Benzoate, Benzoic Acid

E-Leen Green C Pentylene Glycol, Glyceryl Caprylate/Caprate

E-Leen Green OR Pentylene Glycol, Glycerin, Citrus Aurantium Amara (Bitter Orange) Fruit Extract, Citrus Reticulata (Tange-rine) Fruit Extract, Citrus Aurantium Sinensis (Orange) Peel Extract

EasySafe Hexam+ Pentylene Glycol, Water, Hexamidine Diisethionate

In order to select the appropriate blend, you can fi nd below a tool, the E-Leen Selector.

Depending on your development project or key criteria you can choose the best candidate which fi ts your needs or contraints.

E-Leen Green A

E-Leen Green B

EasySafe Hexam +

E-Leen Green C

E-Leen Green OR

Baby care

Body care

pH > 6

Odourless

Natural

Rinse-off

Mildness

Face care

Best choice

The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-tions dealing with manufacture, composition, local procedures, product design, or end usage.

The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-tions dealing with manufacture, composition, local procedures, product design, or end usage.

The above information is accurate to the best of our knowledge. Customers are advised to make their own studies on the usefulness of any ingredient for a particular application. Recom-mended usage information is only provided as indication, and should not be considered as recommendations to use Minasolve®’s products in violation of any laws, patents, or offi cial regula-

3.0 4.0 6.0 7.0 8.0 10.0

MinaSolve® Hexam

Pentiol

Hexiol

Octiol

EasySafe OC 8

EasySafe P 8

EasySafe Green A

A-Leen®5

A-Leen® Aroma-3

Synergistic Green Solutions, COSMOS

Optimized Performance Solutions, Derived Natural

Optimized Performance Solutions, Non Natural

Non Natural

FORMULA PROTECTION

Pure Natural Ingredients, COSMOS

BOOSTER / PRESERVATIVES

Derived-natural

E-Leen® Green B

E-Leen® Green OR

EasySafe Hexam+

E Leen® Green A

E-Leen® Green C

EasySafe GC 8

Caprocine

MinaSolve® CapEasy

pH

12 13

Minasolve® SolutionsMinasolve® is able to provide you a reliable partnership from its brand new offi ces located in Belgium:

► Different research and application Laboratories:

► New product development Lab to prepare the future

► Formulation Lab to assist our customers in their day-to-day activity

► Microbiology Lab for challenge tests

► Formulation Academy for customer training

► International distribution network

► Local and overseas warehouses

Minasolve® social commitment through our partnership with a local & work adapted companyMinasolve® gives great importance to his social commitment. Since Jan-uary 2018, Minasolve® is supporting a local, economic and social project. Indeed Minasolve® has decided to subcontract the sampling logistics (fi lling, labelling, packaging, dispatch) to Axedis.Axedis is a Work Adapted Company located in Belgium where 85% of their employees are disabled people.Our common goal is to offer disabled people a long-term job in a work environment adapted to their needs.

Memphis (TN)USA

Pittsburgh (PA)USA

DunkerqueFrance

Beuvry-la-ForêtFrance

Louvain-la-NeuveBelgium

LeunaGermany

Minasolve® is an affi liate of Minafi n® GROUPCreated in 2004, The MINAFIN® Group, specializes in fi ne chemistry for the life sciences and high tech industries. Activities include industrial subcontracting, development of chemical syntheses and industrial scale-up of custom-made processes as well as proprietary products with high added value for the pharmaceutical, cosmetics, agriculture and high-tech industries. Strong synergies exist between all business units: MINASOLVE, MINAKEM, MINAGRO, PENNAKEM, PRESSURE CHEMICALS, MINASCENT and EcoXtract.

Serving market leaders as well as emerging players we support our customers’ efforts to improve the quality of life in the global community by:

⊲ Improving our chemistry and operational excellence today

⊲ Creating and innovating for tomorrow⊲ Driving our enterprises together to go beyond expectations

860EMPLOYEES

192M€ SALES

85SCIENTISTS

6PRODUCTION

SITES

14 15

145, chemin des Lilas 59310 Beuvry-La-ForêtFrance

8, rue Fond Jean Paques,B-1435 Mont-Saint-GuibertBelgium

Phone: +32 10 238 460e-mail: contact@minasolve.com

www.minasolve.com

2019 04. V4.2