Continuous Processing

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EfficientSafeFlexible

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Flowid Believes in Process Controllability

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T Continuous Domain

Contin

uous

Dom

ain TTT

T

T

T

Flowid DomainContinuous Process Platforms

Scalable to Production

ProblemsLooking for solutions

T

T

TTechnologies

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Spinning Disc Platform

Batch

Dom

ain

Batch Domain

Flowid Believes in Process Controllability

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T Continuous Domain

Contin

uous

Dom

ain TTT

T Flowid DomainContinuous Process Platforms

Scalable to Production

Spinning Disc Platform

Batch

Dom

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Batch Domain

MRTCORB

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FlowFlex

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SpinPro Technology

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Flow chemistry offers significant advantages

Current flow reactor technology does not meet all possible reaction needs:

Precipitate and plugging concerns

Shortened diffusion path is not enough

Simple, rapid scale-up is most desired

Smaller plant footprint desirable

The SpinPro Technology was designed to overcome these limitations.

SpinPro Reactor

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Efficient

Steady state: improve yield and quality

Excellent 2 phase mixing: L/L L/G

Safe

Low volume

Process can be stopped anytime

Flexible

Clean and switch product in seconds

High temperatures and pressure

SpinPro Reactor

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Easy to cleanEasy to assemble and inspectEasy to re-machine the surfaces

SpinPro Reactor

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Pressure: 10 bar

Temperature: 0-160 C

Flowrate: up to 600 l/hr

Reactor volume: 300 ml

Body material: SS316L

Seal material: PTFE

O-ring material: FFKM

Rotation: 4500 rpm

Heat transfer: up to 8.5 kW/stage

Power input: max 1.5 kW

miniSpinPro Reactor

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Material: SiC - Silicon Carbide;

Disc Diameter: 70mm;

Size Reactor: d=100 mm, h=50 mm

Rotation speed: up to 8000 RPM;

Number of Stages: 3;

Flow: up to 100 ml/min;

Volume: about 10 ml;

Pressure: TBD, at least several Bar

Seals: None, magnetic coupling;

Bearings: Ceramic;

Measurement: Possibility to measure temperature at inlet and outlet;

Cooling: Cooling channels will be integrated in the reactor.

SpinPro Continuous L/L Extractor

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Counter Current Liquid-Liquid Extraction

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Clean water Water plus solute dissolved

99% Clean oil Oil plus solute dissolved

Mix - Separate - Mix - Separate - Mix - Separate

Counter Current Liquid-Liquid Extraction

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Efficient

One small device, 1 to 10 stages

Low residence time, increases quality

Safe

Low volume, high pressure

Low RPM

Flexible

Clean and switch product in seconds

Independent control over mixing and separation

SpinPro Continuous L/L Extractor

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Counter current liquid - liquid extractionIndividual control over level of mixing and separationShort contact timeTemperature: 0-100 CFlowrate: up to 100 l/hrBody material: SS316LSeal material: PTFEO-ring material: FFKMPower input: max 3 kW per drive

A continuous processing alternative for every unit operation

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A B

C

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Reactor Extractor Crystallizer

Evaporator CrystallizerA B

C

D

Reactor Extractor Crystallizer

Evaporator Crystallizer

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Pharma: Halogen/Lithium Exchange in Spinning Disc

Tet. Lett., 2010, 51, p. 4793.

94% conversion at 2500 g/hr. 400g produced in 10 min reaction time.A 50g batch process required 40 min of reagent addition time!

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EmulTech Infinity is engineered and builtFirst BuLi reactor experiments successful

Extractor benchmark study successful

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Pharma Development Platform

Engineering and construction of set-up that can produce micro-particles.

EmulTech Infinity is engineered and built

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F&F Process Development Platform

3 liquid inlets

- Highly viscous

- Highly volatile

- Small acid stream

Development time of new products reduced from 6 months to 6 weeks

Pharma Pilot Production Plant

Factory Continuous Style

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Batch vessel SpinPro

Production 25 ton/day 25 ton/day

# Reactors 1 3

Reaction volume 50.000 liter 0,9 liter

Residence time 8 hours 3 seconds

Temperature 85°C 195°C

Pressure 1 bar 12 bar

Energy usage estimate 4MW -0,3MW

Product Concentration 47 wt% 59wt% (max)

Flexibility - On production scale

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Icons: flaticon.com 27

FirstCool

ThenHeat

+25ton -4MWResult:

Batch

Flowid:

+25ton +300kWResult:

Flow

Added value simplified examples: Yield

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Different plants:

Dedicated, steady state adds few percent

Multipurpose, 5%, 10%, 25%

Results of 3% more yield:

3% less raw materials

Less waste and processing

20% more margin

Yield adds directly to bottom line profit

Configuration 0% 3%Product price [€/kg] 100% €20,00 €20,00Raw material 50% €10,00 €9,70Production cost 20% €4,00 €3,90Downstream -0,05Less chemical waste -0,05Overhead 20% €4,00 €4,00Margin 10% €2,00 €2,40

Yearly Production [ton] 1000Yearly Benefit €400.000

Logistics, Energy, Decentralization

Added value simplified examples: Safety

Safety benefits:

Less complex safety systems

Lower risk profile

Less people in operator crew allowed

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Configuration Batch Continuous DeltaCAPEX [k€] 900 300 600Reactor 150 150Safety systems 750 150OPEX [k€/Y] 750 300 450Operator crew 5 2Shifts 3 3k€/y/fte 50 50

2013 April 18th, Texas fertilizer plant explosion

2013 May 4th, Derailment Wetteren

30nasa.gov: http://spaceflight.nasa.gov/gallery/images/shuttle/sts-110/hires/sts110-s-015.jpg 30

Reactor

The Objective is Production

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Examples

Spinning  Disk  Reactor COBR  ReactorCon4nuous  Reactors

Metric tons/DayFast chemistry

Extremely inert material

High heat transferMulti-stage reactions

Metric tons/DayFast ChemistryExtreme mixing efficiencyHandles gas/liquid/solids

Multi-stage reactions

Metric tons/DaySlow Chemistry & Crystallization

Handles gas/liquid/solids

Multi-stage reactions

Three “Lab to Manufacture” Platforms

Believes

Turning industry up side down

Miniaturising processes

Boosting efficiency, safety and flexibility

From batch to continuous processes using scalable continuous technologies

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Project, Product, Application approach

To innovate you need to be able to manage the risks involved

Fast, clear,

Consequent, great looking

Cooperate

Unite

Cooperate

Tangible (in FlowFlex modules)

Learn by solvingclient problemsFocus on production Believe in partnerships