antimicoticos
TRANSCRIPT
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ANTIMICOTICOSPEDRO SAID SANCHEZ LUNA
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POZACONAZOL
Analogo del itraconazol
Levaduras y hongos
filamentosos
Levaduras igual que
voriconazol
Mecanismo de accion igual
que imidazoles
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ABSORCION, DISTRIBUCION Y EXCRECION
40 mg/ml Admon. Junto con alimentos T ½= 25-31 h Vol. De dist=
331-1341 L
Union a proteinas
>98%
Equilibrio 7-10 dias
Renal= NoHepatica= Si
77% heces66% sin
modificacion
Glucoronidacion con UDP hepatica
hemodialisis Absorcion en medio acido
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USOS TERAPEUTICOS
Candidiasis AspergilosisOtras
infecciones diversas
Mucormicosis No hay IV
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INTERACCIONES FARMACOLOGICAS
Inhibe CYP3A4
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EFECTOS SECUNDARIOS
Nausea
vomito
diarrea
Dolor abdomi
nalCefalea
Malformacion
es
No niños < 8 años
DOSIS:Adultos y
niños 200mg/3 vcs
al dia
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EQUINOCANDINAS
1970 Candida y aspergillus 1,3-β-D-glucanos
CaspofunginaAnidulafungina
Micafungina
Lipopeptidos ciclicos con
nucleo hexapeptidico
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CARACTERISTICAS FARMACOLOGICAS GENERALES
VO>97% proteinasLCR
Falta de aclaramiento
renalInsuf hepatica
Efectos secundarios
leves
EmbarazoMIC= candida 0.015-0.5 μg/ml
C>M>A
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CASPOFUNGINA
Cancidas
Lipopeptido semisintetic
o hidrosoluble
Glarea lozoyensis
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METABOLISMO Y EXCRECION
Hidrolisis y N-acetilacion Orina y heces
Insuf hepatica AUC= 55% y
76%
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USOS TERAPEUTICOS
Candidiasis Aspergilosis
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EFECTOS SECUNDARIOS Y DOSIS
Flebitis
Efectos similares a histamina
IV 1 vez/dia en 1h
70 mg- 50 mg
Insuf hepatica 35 mg
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MICAFUNGINA
Equinocandina semisintetica hidrosoluble
Coleophoma empedri
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ABSORCION, DISTRIBUCION Y EXCRECION
Farmacocinetica lineal Heces 71%
Higado por arilsulfatasa y
COMT
Hidroxilacion por CYP3A4 Aclaramiento
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USOS TERAPEUTICOS Y DOSIS
Candidiasis de invasion profunda
Candidiasis esofagica
VI 100mg/dia
en 1h
50mg de profilaxis
150mg candidiasis esofagica
No hay dosis de
carga
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ANIDULAFUNGINA
Compuesto semisintetic
o
Aspergillus nidulans
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ABSORCION, DISRIBUCION Y EXCRECION
Degradacion quimica
Anillo hexapeptidico
Proteolisis enlaces
peptidicos
No renal y no hepatico
3mg de etanol x 50mg de
anidulofungina
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USOS TERAPEUTICOS Y DOSIS
Candidiosis profunda
Candidiosis esofagica
En solucion dextrosa 5% o
salina
No mas de 1.1mg/min
Invasion profunda
200mg-100mg
Esofagica 100mg-50mg
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GRISEOFULVINA
Insoluble en agua
MECANISMO DE ACCION:
Inhibe Fx de microtubulos
Destruye ensamble del huso mitotico
Parecido a la colquicina
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ABSORCION, DISTRIBUCION Y EXCRECION
dosis de 0.5g = [p] = 1μg en 4h
Polvos microscopico y
ultramicroscopico
Ultramicrocristalino 50% >
microcristalino usual
T ½= 1 dia y 50% se detecta en orina
5 dias despues6-metilgriseofulvina Barbituricos
Celulas precursoras de queratina
Estrato corneo 4-8 h despues
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USOS TERAPEUTICOS
Piel,pelo y uñasMicrosporum, trichophyton o
epidermophyton
Tiña de la cabeza, de piel galabrosa, crural, corporal, de las manos, barba,
y pie
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DOSIS
2.3mg/kg (500mg)
niños
500mg a 1g adultos
1.5-2g al dia Cada 6h
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EFECTOS SECUNDARIOS
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SNC
Cefalea 15%
Neuritis periferica
letargia
Confusion mental
Fatiga
Sincope
Vertigo
Vision borrosa
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DIGESTIVO
nausea
Vomito
Diarrea
pirosis
flatulencia
Xerostomia
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HEMATOLOGICOS
leucopenia
neutropenia
Basofilia punteada
monocitosis
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Hepatotoxicidad
Efectos renales Albuminuria
Cilindruria
En piel Urticaria por frio y calor
Fotosensibilidad
Liquen plano
Eritema
Erupciones vesiculares y morbiliformes