diamax - effective in glycemic control - prodiet
TRANSCRIPT
Diamax
DIAMAX• DM types 1 and 2• Glucose intolerance • Gestational diabetes • Stress hyperglycemia
Diabetic population in the world
Diamax
• 1 adult in 10 will have
diabetes by 2030
Ranking:• China: 92,3 mi
• Índia: 63 mi
• EUA: 24,1 mi
• Brasil: 13,4 mi
• Rússia: 12,7 mi
IDF 2012
Diamax
Diabetes Mellitus
Metabolic Disease
DM 1
Insuline secretion deficiency
DM 2
Insuline resistance
Diabetes:
Glycemia: ≥ 126 mg/dL
Glucose intolerance:Glycemia: 100 to 125 mg/dL unfed
Intense organic catabolism with protein and fats
breach for use as energy source. Nutritional
status compromised.
Occurs hyper-insulinism status, glucagon
increase with proteolysis and lipolysis stimulus
and resulting hyperglycemia. Nutritional status
retained or overweight-obesity.
.
Diamax
Diabetes Mellitus
DM 1
Insuline secretion
deficiency
DM 2
Insuline resistance
SBD 2012
DM 1Symptoms that appear quickly
• Urinating excessively.
• Extreme thirst.
• Weight loss.
• Coma
• Consciousness loss
Diamax
Early diagnosis
can save a life!
Diabetes: symptoms
Diabetes: symptoms
SBD 2012
DM 2Discrete and gradual symptoms
• Urinating excessively.
• Extreme thirst.
• Increased appetite.
• Weight loss (also in obese).
• Tiredness.
• Blurred vision.
• Frequent infections (skin).
Diamax
Early diagnosis is
the best to avoid complications!
Diabetes Main Complications
World Health Organ Tech Rep Ser, 916:i-viii, 1-149, 2003 e SBD 2012
Diabetic nephropathy: responsible for ~ 40% Hemodialysis
Diabetic retinopathy: blindness main cause
Circulation problems and nerve involvement.
Diamax
Acute myocardial infarction: responsible for the death of 2/3
Circulation and healing problems: increases in 40 times theamputation risk
Diabetes: Control, Risk and Hospital Permanence
DIABETES NOT COMPLICATED
OUT-PATIENT ACTIONS
ACUTE COMPLICATIONS
CHRONIC COMPLICATIONS
HOSPITAL ACTIONS:PROCEDURES AND HOSPITALIZATIONS
LOW COST
Low Risk
HIGH PERMANENCE
High Risk
LOW PERMANENCE
High Risk
Pimazoni. in Grupemef. 2001
Diamax
DIAMAX
Why oral feeding ?
• Preferably application
• Nutritional solution that enables the
control of glycemic homeostasis in
harmony with the daily diet
Diamax
BENEFITS CHARACTERISTICS
Nutritional recovery through a
specialized formula
Diamax
44%carboidratos
39%Lipídios
17%proteínas
Grade ADiten2011
Specialized formulaAllows better glycemic
control in both short and long term
proteins carbohydrates
lipids
BENEFITS CHARACTERISTICS
• Appropriate nutritional status
• Better insulin sensitivity
Diamax
Grade A/D- Diten 2011
ADA 2008/10
Nutritional Therapy:Must avoid the excessive
energy supply
1.0cal/ml
• Renal functioning protection
• Improves lipid oxidation
Diamax
• 50% Calcium caseinate
• 50% Isolated soy protein
• L-carnitine
ADA 2008/2010
Protein intake:15 to 20% VET proteins
BENEFITS CHARACTERISTICS
Hermansen et al. Diabetes Care 24, 2001
Control Soy protein Soy protein x Control
Significant difference(%)
Initial After 6 weeks
Initial After 6 weeks
p≠ (%) p§
Total Cholesterol
5,59±0,81
5,45±0,88
5,68±0,84 5,11±0,78 0,0041 - 8±15 0,0826
LDL 3,64±0,80
3,33±0,72
3,63±0,78 3,01±0,68 0,0044 - 10±16 0,0483
HDL 1,28±0,29
1,33±0,34
1,31±0,22 1,38±0,35 0,2024 0±20 0,8517
TG (mmol/l) 1,70±1,49
1,79±1,17
1,70±1,17 1,63±0,97 0,3632 - 22±43 0,0400
ApoB100(g/l) 0,95±0,26
0,98±0,25
1,09±0,21 0,86±0,19 0,0249 - 30±38 0,0027
Lp(a)(U/l) 32,3±37,5
32,4±39,8
29,5±29,9 33,9±37,7 0,3488 - 8±34 0,1769
LDL/HDL Rate 2,95±1,02
2,52±0,62
2,82±0,75 2,20±0,61 0,0007 - 12±18 0,0120
Diabetes (Soy Protein)
òBiochemical markers for Cardiovascular Disease
Diamax
Diabetes (Soy Protein)
Studies suggest that
the vegetable protein
exerts protective
function to kidneys.
Diamax
Diabetes (Complications)DIABETIC NEPHROPATHY
• Frequent microvascular chronic complication
Cumulative incidence in 10 years:Brazilians 31%Finnish 34%Israelis 51%
• 1/3 of individuals with type 2 diabetes develop nephropathy
Diamax
Murussi et al. Arq Bras Endocrinol Metab, 47(3), 2003
Diabetes (L-Carnitine)
Coelho et al. Rev. Nutr., 18(5), 2005
Diamax
HiperglicemiaProdução de Malonil-CoA
Inibe o transporte de ácidos graxos para obtenção de energia
HyperglycemiaProduction of
Inhibits the fatty acids transport for energy obtainment
Diabetes (L-Carnitine)
Coelho et al. Rev. Nutr., 18(5), 2005
Diamax
Carnitine
Fatty acid
Metabolized for energy obtainment
• Slow absorption CH assists
in glycemic control
• Best palatability
Diamax
• 100% Tapioca maltodextrin
• Contains sucralose
Grade D - Diten 2011
ADA 2008/10
Carbohydrates: 33 to 50% VETUp to 50% VET
carbohydrates
BENEFITS CHARACTERISTICS
Sucralose
Only sweetener agent derived from sugar through a process,
that developed an exceptionally stable molecular structure and
the body does not recognize it as sugar, is not metabolized and
is eliminated after consumption and does not have
carcinogenic effect.
Diamax
FDASucralose
Maximum dose: 5mg/Kg/day
BENEFITS CHARACTERISTICS• Regularization of the
intestinal transit
• Assists in glycemic control
• Fibers 15 g/L
• 65% Polydextrose
• 35% Soy polysaccharide
Diamax
Grade B - Diten 2011
Grade B - ADA 2008/10
Dietary fibers~ 50g/day: glycemic control 14g/1000cal: DM prevention
POLYDEXTROSE
Jie, Z et al. Am J Clin Nutr,72:1503–9, 2000
Before and after of polydextrose consumption
Consumption days Group B (n=30)4 g of polydextrose/day
Group C (n=30) 8 g of polydextrose/day
Group D (n=30)12g polydextrose/day
0 101±12 95±9 88±12*
29 102±12 95±10 88±10*
*p<0,01
Diamax
Fecal Microbiota before and after of Polydextrose consumption
Before Group B (n=30) Group C (n=30) Group D (n=30)Lactobacillus 0,26±0,08 0,32±0,14 0,28±0,12
Bifidobacterium 0,46±0,21 0,40±0,16** 0,52±0,19
AfterLactobacillus 1,10±0,28* 1,36±0,53* 1,92±0,48*Bifidobacterium 1,54±0,37* 3,05±1,13* 5,29±1,74*
POLYDEXTROSE (MICROBIOTA EFFECTS)
Jie, Z et al. Am J Clin Nutr,72:1503–9, 2000
*p<0,01**p<0,05 Prebiotic
Effect
Diamax
BENEFITS CHARACTERISTICS
• Cardiovascular complications
incidence reduction
39% Lip
• 54% A.T.O. Sunflower Oil
• 39% Canola Oil
• 5% Corn Oil
• 2% Soy Lecithin
Diamax
lipids
BENEFITS CHARACTERISTICS• Cardiovascular complications
incidence reduction
• Insulin resistance reduction
Saturated: 5%
Monounsaturated: 26%Poly-unsaturated: 9%
Diamax
Grade D - Diten 2011
Grade A – ADA 2008/10
AHA 2006
MUFAS: LIP preferential
SFA: up to 7% VET
SFA: up to 7% VET
lipids
MONOUNSATURATED FATTY ACIDS (MUFAS)
MUFAS rich diet:
Favorable effect on lipoprotein profile: #HDL $LDL
Less insulin requirement
Improves insulin sensitivity
Lower levels of:– Postprandial and Plasmatic glycemia
– Glucagon
– Glycosuria
Diamax
lipids
Vidal et al., Rev Bras de Nutr Clin, 20(2); 2005
BENEFITS CHARACTERISTICS
• Homeostasis glycemic
maintenance
• Caloric density:1.0 cal/ml
• 100% Tapioca maltodextrine
• 15g/l of fibers:
65%FS - Polydextrose
• 26% MUFA (Monounsat. Fat. Ac.)
• Sweetener agent: sucralose
Diamax
Living well with diabetes is difficult, undoubtedly, but live with its chronic complications is certainly much worse.
This is our challenge: setting the DIAMAX® as an ally in the quest for improving the life quality of diabetic patients...
Diamax
"All data herein were collected in advertising material distributed by the companies to the market and of public domain"
INTERNAL USE ONLY
DiamaxMajor Competitors
Diamax Nutri Diabetic Novasource GC GlucernaSR
Prodiet NC Support Nestlé Abbot
"All data herein were collected in advertising material distributed by the companies to the market and of public
domain" INTERNAL USE ONLY
DiamaxMajor Competitors
Diamax Nutri Diabetic Novasource GC GlucernaSR
Prodiet NC Danone Nestle Abbot
CaloricDensitycal/ml
1.0 1.0 1.0 1.0
CaloricDistribution
PT 17% 43g/LCH 44% 110g/LFAT 39% 43g/L
PT 15% 39g/LCH 39% 98g/LFAT 46% 51g/L
PT 18% 49g/LCH 34% 95g/LFAT 48% 60g/L
PT 20% 47g/LCH 47% 110g/LFAT 33% 34g/L
CH Source100% Tapioca Maltodextrin
90% Maltodextrin10% Fructose
50% Tapioca starch34% maltodextrin16% fructose"
50% Maltodextrin23% Fructose20% Maltitol7% Fibers
Monounsaturatedfatty acid(%)
26 33,2 NI 25
Apresent. 200ml and 1L 200ml and 1L 200ml and 1L 220ml
