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16th May , 2014 Volume No.: 33 Issue No.: 03

Contents • Message from GNIPST • Letter to the Editor • News Update • Health awareness • Disease Outbreak News • Forth Coming Events • Drugs Update • Campus News • Student’s Section • Editor’s Note • Archive •

Vision

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCE

EDITOR: Soumya Bhattacharya GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND

TECHNOLOGY

GNIPST Photo Gallery For your comments/contributionOR

For Back-Issues, mailto:gnipstbulletin@gmail.com

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MESSAGE FROM GNIPST

GNIPST BULLETIN is the official publication of Guru Nanak Institute of Pharmaceutical Science & Technology. All the members of GNIPST are proud to publish the 33rd Volume of “GNIPST BULLETIN”. Over the last three years this bulletin updating readers with different scientific, cultural or sports activities of this prestigious institute and promoting knowledge of recent development in Pharmaceutical and Biological Sciences. Student’s section is informing readers about some curious facts of drug discovery, science, sports and other relevant fields. We look forward to seeing your submission and welcome comments and ideas you may have.

NEWS UPDATE

World Health Day, 2014 World Health Day was observed on 7th April globally with the theme of Preventing Vector-borne Disease. More than half the world’s population is at risk from diseases such as malaria, dengue, leishmaniasis, Lyme disease, schistosomiasis, and yellow fever, carried by mosquitoes, flies, ticks, water snails and other vectors. Every year, more than 1 billion people are infected and more than 1 million die from vector-borne diseases. On this World Health Day – 7 April – WHO is highlighting the serious and increasing threat of vector-borne diseases, with the slogan “Small bite, big threat”.

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Protein's role revealed in preventing heart muscle growth leading to heart failure

(12th May, 2014)

For the first time the protein Erbin has been shown to be an important brake that helps prevent pathological cardiac hypertrophy. Researchers showed that damage to this protein leads to excess growth of heart muscle, a decrease in function, and severe pathological growth of heart muscle. Their research has implications for breast cancer treatment, as Erbin interacts with the receptor Her2/ErBb2, which is overexpressed in approximately 30 percent of breast cancers.

For detail mail to editor

Artificial magnetic bacteria 'turn' food into natural drugs

(12th May, 2014)

Scientists from the University of Granada have successfully created magnetic bacteria that could be added to foodstuffs and could, after ingestion, help diagnose diseases of the digestive system like stomach cancer. These important findings constitute the first use of a food as a natural drug and aid in diagnosing an illness, anywhere in the world. the researsearchers members of Bionanomet, of the Department of Inorganic chemistry of the University of Granada have conducted this research with BIOSEARCH. their results have been published in the latest issue of Advanced Functional Materials.

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For detail mail to editor

Scientists discover a natural molecule to treat type 2 diabetes: Molecule mimics some effect of physical exercise (12th May, 2014) Researchers at the Université Laval Faculty of Medicine, the Quebec Heart and Lung Institute Research Center, and the Institute of Nutrition and Functional Foods have discovered a natural molecule that could be used to treat insulin resistance and type 2 diabetes. The molecule, a derivative of omega-3 fatty acids, mimics some of the effects of physical exercise on blood glucose regulation.

For detail mail to editor Diets rich in antioxidant resveratrol fail to

reduce deaths, heart disease or cancer (12th May, 2014)

A study of Italians who consume a diet rich in resveratrol -- the compound found in red wine, dark chocolate and berries -- finds they live no longer than and are just as likely to develop cardiovascular disease or cancer as those who eat or drink smaller amounts of the antioxidant.

For detail mail to editor

Immune therapy might be effective for multiple myeloma (12th May, 2014)

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A new study by researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) provides evidence that genetically modifying immune cells might effectively treat multiple myeloma, a disease that remains incurable and will account for an estimated 24,000 new cases and 11,100 deaths in 2014.The researchers modified a type of human immune cell -- called T lymphocytes, or T cells -- to target a molecule called CS1, which is found on more than 95 percent of myeloma cells, and to kill the cells. The researchers grew the modified cells in the lab to increase their numbers and then injected them into an animal model where they again killed human myeloma cells.

For detail mail to editor

Genetic blueprint for cancerous appendix tumors identified (12th May, 2014) Using next generation DNA sequencing, scientists have identified potentially actionable mutations in cancers of the appendix. When specific mutations for a cancer type are identified, patients can be treated with chemotherapy or other targeted agents that work on those mutations. Little is known about the molecular biology of two types of appendix tumors, low-grade appendiceal mucinous neoplasm (LAMN) and adenocarcinoma, but both can lead to pseudomyxoma peritonea (PMP), a critical condition in which cancerous cells grow uncontrollably along the wall of the abdomen and can crush digestive organs.

For detail mail to editor

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HEALTH AWARENESS

Health risks in Adoloscent

Around 1 in 6 persons in the world is an adolescent: that is 1.2 billion people aged 10 to 19.

Most are healthy, but there is still significant death, illness and diseases among adolescents. Illnesses can hinder their ability to grow and develop to their full potential. Alcohol or tobacco use, lack of physical activity, unprotected sex and/or exposure to violence can jeopardize not only their current health, but often their health for years to come. Promoting healthy practices during adolescence, and taking steps to better protect young people from health risks are critical for the prevention of health problems in adulthood, and for countries’ future health and social infrastructure. Main health issues include:

Early pregnancy and childbirth Complications linked to pregnancy and childbirth are the second cause of death for 15-19-year-old girls globally. Some 11% of all births worldwide are to girls aged 15 to 19 years, and the vast majority are in low- and middle-income countries. The 2014 World Health Statistics put the global adolescent birth rate at 49 per 1000 girls this age - country rates range from 1 to 229 births per 1000 girls. This indicates a marked decrease since 1990. This decrease is reflected in a similar decline in maternal mortality rates among 15-19 year olds. One of the Millennium Development Goals, MDG 5, is to achieve universal access to reproductive health, for which one of the indicators is the pregnancy rate among the 15 to 19 age group. Better access to contraceptive information and services can reduce the number of girls becoming pregnant and giving birth

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at too young an age. Laws that specify a minimum age of marriage at 18 and which are enforced can help. Girls who do become pregnant need access to quality antenatal care. Where permitted by law, adolescents who opt to terminate their pregnancies should have access to safe abortion. HIV More than 2 million adolescents are living with HIV. Although the overall number of HIV-related deaths is down 30% since the peak 8 years ago, estimates suggest that HIV deaths among adolescents are rising. This increase, which has been predominantly in the WHO Africa Region, may reflect the fact that although more children with HIV survive into adolescence, they do not all then get the care and support they need to remain in good health and prevent transmission. In sub-Saharan Africa only 10% of young men and 15% of young women aged 15 to 24 are aware of their HIV status. MDG 6 to halt the spread of HIV/AIDS has indicators including the prevalence among 15 to 24 year olds and the proportion of this age group with comprehensive correct knowledge of HIV/AIDS. Young people need to know how to protect themselves and have the means to do so. This includes being able to obtain condoms to prevent sexual transmission of the virus and clean needles and syringes for those who inject drugs. Better access to HIV testing and counselling is also needed. Other infectious diseases Thanks to improved childhood vaccination, adolescent deaths and disability from measles have fallen markedly – for example, by 90% in the African Region between 2000 and 2012. But diarrhoea, lower respiratory tract infections and meningitis are among the top 10 causes of death for 10 to 19 year olds. Mental health Depression is the top cause of illness and disability among adolescents and suicide is the third cause of death. Violence,

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poverty, humiliation and feeling devalued can increase the risk of developing mental health problems. Building life skills in children and adolescents and providing them with psychosocial support in schools and other community settings can help promote good mental health. Programmes to help strengthen ties between adolescents and their families are also important. If problems arise, they should be detected and managed by competent and caring health workers. Violence Violence is a leading cause of death. An estimated 180 adolescents die every day as a result of interpersonal violence. Around 1 of every 3 deaths among adolescent males in the low- and middle-income countries in the WHO Americas Region is due to violence. Globally, some 30% of girls aged 15 to 19 experience violence by a partner. Promoting nurturing relationships between parents and children early in life, providing training in life skills, and reducing access to alcohol and firearms can help to prevent violence. Effective and empathetic care for adolescent survivors of violence and ongoing support can help deal with the physical and the psychological consequences. Alcohol and drugs Harmful drinking among adolescents is a major concern in many countries. It reduces self-control and increases risky behaviours, such as unsafe sex. It is a primary cause of injuries (including those due to road traffic accidents), violence (especially by a partner) and premature deaths. It also can lead to health problems in later life and affect life expectancy. Setting a minimum age for buying and consuming alcohol and regulating how alcoholic drinks are targeted at the younger market are among the strategies for reducing harmful drinking. Drug use among 15 to 19 year olds is also a concern.

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Injuries Unintentional injuries are a leading cause of death and disability among adolescents. In 2012, some 120 000 adolescents died as a result of road traffic accidents. Young drivers need advice on driving safely, while laws that prohibit driving under the influence of alcohol and drugs need to be strictly enforced. Blood alcohol levels need to be set lower for teenage drivers. Graduated licences for novice drivers with zero-tolerance for drink-driving are recommended. Drowning is also a major cause of death among adolescents – 60 000, two-thirds of them boys, drowned in 2012. Malnutrition and obesity Many boys and girls in developing countries enter adolescence undernourished, making them more vulnerable to disease and early death. The number of adolescents who are overweight or obese is increasing in both low- and high-income countries. Exercise and nutrition Available survey data indicate that fewer than 1 in every 4 adolescents meets the recommended guidelines for physical activity - 60 minutes of moderate to vigorous physical activity daily. Anaemia resulting from a lack of iron affects girls and boys, and is the third cause of years lost to death and disability. Iron and folic acid supplements help to promote health before adolescents become parents. Developing healthy eating and exercise habits at this age are foundations for good health in adulthood. Reducing the marketing of foods high in saturated fats, trans-fatty acids, free sugars, or salt and providing access to healthy foods and opportunities to engage in physical activity are important for all but especially children and adolescents. Tobacco use The vast majority of people using tobacco today began when they were adolescents. Prohibiting the sale of tobacco products to minors and increasing the price of tobacco products through

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higher taxes, banning tobacco advertising and ensuring smoke-free environments are crucial. Globally, at least 1 in 10 younger adolescents (aged 13 to 15) uses tobacco, although there are areas where this figure is much higher. Cigarette smoking seems to be decreasing among younger adolescents in some high-income countries. Rights of adolescents The rights of children to survive, grow and develop are enshrined in international legal documents. The Committee on the Rights of the Child (CRC), which oversees the child rights convention, in 2013 published guidelines on the right of children and adolescents to the enjoyment of the highest attainable standard of health. In 2003, the CRC issued guidelines on states’ obligations to recognise the special health and development needs and rights of adolescents and young people. The Convention on the Elimination of Discrimination Against Women (CEDAW) also sets out the rights of women and girls to health and adequate health care. WHO response

In May 2014, WHO published a major report called “Health for the world’s adolescents”. The report analyses what is known about adolescents’ health, including what promotes or undermines it, highlights gaps in policies and services, and draws together guidance and recommendations from across WHO. The report, which focuses on the health sector, examines areas of significant improvements and innovative approaches. Overall, WHO carries out a range of functions to improve the health of young people, including:

• drawing up evidence-based guidelines to support health services and other sectors;

• making recommendations to governments on adolescent health and adolescent friendly health services;

• raising awareness of health issues for young people among the public and special groups.

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Key facts

• An estimated 1.3 million adolescents died in 2012, mostly from preventable or treatable causes.

• Road traffic injuries were the leading cause of death in 2012, with some 330 adolescents dying every day.

• Other main causes of adolescent deaths include HIV, suicide, lower respiratory infections and interpersonal violence.

• Globally, there were 49 births per 1000 girls aged 15 to 19, according to 2010 figures.

• Half of all mental health disorders in adulthood appear to start by age 14, but most cases are undetected and untreated.

DISEASE OUTBREAK NEWS

Ebola virus disease, West Africa (10th May, 2014)

The Ministry of Health (MOH) of Guinea has reported a cumulative total of 233 clinical cases of Ebola Virus Disease (EVD), including 157 deaths. Since the last update of 9 May 2014, there have been no new cases confirmed by ebolavirus PCR and no new deaths bringing the total number of confirmed cases to 129, including 83 deaths.Read more

FORTHCOMING EVENTS

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FIP Congress 2014 - Access to Medicines and Pharmacist today, Better outcomes tomorrow

DRUGS UPDATES

FDA approves Zontivity to reduce the risk of heart attacks and stroke in high-risk patients (8th May, 2014)

The U.S. Food and Drug Administration today approved Zontivity (vorapaxar) tablets to reduce the risk of heart attack, stroke, cardiovascular death, and need for procedures to restore the blood flow to the heart in patients with a previous heart attack or blockages in the arteries to the legs. Read more

CAMPUS NEWS

Reminiscence, 2014(GNIPST Reunion) was held in College campus on 2nd February,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 in College campus ground.

An industrial tour and biodiversity tour was conducted in Sikkim for B.Pharm and B.Sc. students under the supervision of Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

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B.Pharm 3rd year won the GNIPST Football Champions trophy, 2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.

Students of GNIPST organized pre puja celebration programme, ‘Saaranya’ on 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th September, 2013 at Dakshineswar Kali Temple and Adyapith, Kolkata. On this remarkable event about hundred people have received garments. More than hundred students and most of the faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) and Pharmacist’s Day (25th September) on 25th and 26th September, 2013 in GNIPST Auditorium. A seminar on ‘Violence against woman’ and ‘female foeticide’ was held on GNIPST Auditorium on 25th September organized by JABALA Action Research Organization. On 26th September an intra-college Oral and Poster presentation competition related to World Pharmacist’s day and Heart day was held in GNIPST. Ms. Purbali Chakraborty of B.Pharm 4th year won the first prize in Oral Presentation. The winner of Poster presentation was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). A good number of students have participated in both the competition with their valuable views.

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STUDENTS’ SECTION

WHO CAN ANSWER FIRST????

Which Fictional Archaeologist was named after George Lucas’ pet dog?

Which marsupial gets its name from Telegu word means Pig Rat?

Answer of Previous Issue’s Questions:

A) Warner Brothers B)Ramesh Agarwal

Identify the person

Answer of Previous Issue’s Image: Yakov G. Sinai, won Able Prize in 2014

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at gnipstbulletin@gmail.com

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EDITOR’S NOTE

I am proud to publish the 3rd issue of 33rd Volume of GNIPST BULLETIN. GNIPST BULLETIN now connected globally through facebook account ‘GNIPST bulletin’

I want to convey my thanks to all the GNIPST members and the readers for their valuable comments, encouragement and supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha and Mr. Debabrata Ghosh Dastidar for their kind co-operation and technical supports. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE

Teacher’s day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium.

Azalea (exotic flower ) , the fresher welcome programme for newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium.

One day seminar cum teachers’ development programme for school teachers on the theme of “Recent Trends of Life Sciences in Higher Education” organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum

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Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science.

The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day.

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GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years’ post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to 120.

AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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