plateforme de calcul pour les sciences du vivant interdisciplinary activities v. breton...

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  • IntroductionOur core activity is to understand the universe at small and at cosmological distancesCompetences acquired to support core projects can benefit other scientific domainsAcceleratorsDetectorsComputingWe are called upon to contribute our scientific competence to other fields of science and to solve certain problems raised by the societyDevelopment of interdisciplinary research on two main frontsInterface with life sciences (on the steps of Marie Curie)Processing of nuclear wastes

  • Interdisciplinary research at IN2P3 IN2P3Life sciences - Medical imaging - Hadron therapeutic cancer treatment - DNA Sequencing - Study of Low dosesChemistry - Radiochemistry - Detection of trace elements - Waste treatment

    MIPPU (mathematics, computer science, physics and universe) - Theoretical physics - Materials for detectors - Solid state physics - Behavior of irradiated materials - Aggregates - Telecommunications - Grids Social sciences - Dating - Risk Perception - History of sciences Engineering - Microelectronics - Highly stable lasers - Waste treatmentEnvironment - Waste treatment - Oceanography - Low level radioactivity

    Sciences of the universe - Astrophysics and cosmology - Oceanography - Waste treatment - Low-level radioactivity - Dating

  • Physics and chemistry for nuclear energy and environmentNuclear energy is probably going to regain momentum in the close futureAwareness of the impact of fossil energy on greenhouse effectGrowing need of emerging countriesLimited reserves and foreseeable exhaustion of fossil energyLimited capacity of renewable energiesIn this perspective, convincing answers must be found to issues related toWaste managementSecurityNon-proliferationNew types of reactors, new methods for characterizing nuclear material are under study

  • Research activities at IN2P3 and DAPNIARadiochemistry: Physics and Chemistry of radioactive materials produced in the present and future nuclear energy sector, in the environment (waste storage sites) and in medecineResources: 5 IN2P3 laboratories, 45 permanent staff + 30 non permanent staff Metrology: measurement and monitoring of radioactivity in the environmentResources: 20 staff + 8 NP staffStudy of physics and scenarios for future reactorsResources: 15 staff + 8 NP staffNuclear physics for future reactors and other applicationsResources: 27 staff + 16 NP staff

  • Organization of work and perspectivesOrganization of workCNRS interdisciplinary program PACE (Nuclear Cycle Post Processing program)CNRS Research Groups : PRACTIS, NOMADE, GEDEPEONEuropean FP6 projects: ACTINET6, IP-EUROTRANS, Collaboration with CEA and industry (EDF, ANDRA, FRAMATOME, COGEMA)

    Scientific prospects for the next 10 years: carry out upstream research in the electro-nuclear fieldAcquisition of fundamental data (spallation, captures, fission)Study hybrid systems for transmutationContribute to the study of innovating systems for the future nuclear energy

  • Interaction of particles with matterInterdisciplinary research on accelerators and ion beamsMain research areasCollision processesUnderstanding energy deposit by polyatomic projectiles such as aggregates or molecules in solidsSimulation of particle interaction with materialsExperimental simulation of material aging under irradiationUse of structural changes induced by ion and aggregate beams

    Resources: > 4 laboratories, ~ 34 staff in IN2P3 laboratories (20% of the french research community)

  • Organization of work and perspectivesOrganization of workNatural collaboration with the scientific communities using accelerators and ion beamsLack of organization around the different levels of interaction between particle and matterCommunity of 170 researchers spread in 24 laboratories

    PerspectivesCreation of a Research Group (GDR) fundamental research on particle matter interactionIdentified common topics of interestElementary collision processesFragmentation paths, energy and excitation transfer mechanisms in molecules and aggregatesRelaxation paths for materials under irradiationModeling of matter energy transfer and relaxation phases Impact of different levels of disorder on biological, physical and chemical properties of materials

  • Life sciencesMain research areasPhysical and chemical characterization of living organismsRadiobiologyRadiotherapy Medical and biological imagingInformatics for life sciencesResources10 laboratories (including CEA)70 staff members (50 researchers, 20 technical staff)A significant scientific production29 thesis, 65 papers, 14 patentsPartnersHospitals, universities, CEA (life science department), CNRS (life science, engineering departments), INSERM (national institute for medical research), FP6 European projects

  • Physical and chemical characterization of living organismsTools: accelerators of light / polyatomic ionsTechniques used: imaging, chemical analysis, local irradiation Resources: 4 laboratories, 13 staff + 11 NP staff3 research areasCharacterization of interfaces between biomaterials and living tissuesCharacterization of biomolecules for bacteriology and environmentChemical exploration of cells to study exposure to nanoparticles and metals

  • RadiobiologyRadiobiology is about characterizing and quantifying irradiation effects on biological systemsTools: 4 accelerator facilities (neutron, proton and ion beams)Resources: 4 laboratories, ~ 8 staff and 5 NP staffResearch areasIntermolecular dynamics under irradiationSearch for molecules or nano-objects increasing or inhibiting radio sensitivityDNA lesions and genomic instabilities induced by irradiationIrradiation of Intracellular targets intra and extra cellular messaging after irradiationDirect and indirect impact of radiations on DNA

  • RadiotherapyRadiotherapy is about using ionizing particles to kill cancerous cellsResources: 4 laboratories, 8 staff and 10 NP staff Research areasTreatment planningDevelopment of accelerators for radiotherapy treatmentQuality control (beam dosimetry, on-line monitoring)Simulation of an electron accelerator using GATE

  • Medical and biological imagingDevelopment of imaging systems based on technological expertise Resources: 10 laboratories, 35 staff + 20 NP staffResearch areas cover imaging devices from molecule to manIn vitro imagingIn vivo imaging (PET, SPECT, MRI)Multi-modal imagingPer-operative imagingHighlight: creation of a laboratory dedicated to brain functional imagingLocation: OrsayJoint IN2P3-CNRS Life Science Department laboratory

    Per-operative compact imager, IPN Orsay

  • Activities in medical imaging at IN2P3 and DAPNIA

  • Informatics for life sciencesResources: 7 laboratories6 staff + 20 NP staffResearch areas Simulation for dosimetry and imaging (GATE) Simulation for radiobiology (Geant4)Grids for life sciences and healthcareSimulation ModelingData handlingand analysisFundamental research in nuclearand particle physics DetectorsGEANT4GATEGridsInnovating technologiesNuclear MedecineRadiobiologyRadiotherapyLife sciencesHealthcareMedical andBiological imaging

  • Grid-enabled in silico drug discoveryGoal: reduce time and cost to develop new drugs by selecting the best drug candidatesParticularly relevant to neglected and emerging diseasesStrategy: deploy virtual screening on gridsScreening = selection of molecules active on a given protein targetGrid added value: access to huge computing resourcesSuccessful deployment on EGEE against malaria and bird fluMalaria: 46 millions docking probabilities computed in 6 weeks in the summer 2005Bird flu: 100 CPU years to find new drugs against mutated neuraminidase N1Role of IN2P3: coordination of the grid deploymentsCountries contributing to EGEE Biomedical Virtual OrganizationNumber of malaria related jobs waiting and running on EGEE vs time

  • Organization of work at the interface with life sciencesInterface with life sciences has been loosely structured in the last millenniumLocal collaboration with hospitals or university groupsTransfer of expertise for technical developmentsLife sciences are moving into big scienceMolecular biology experimental platforms produce very large volumes of data studied by international collaborations Research equipments become national (NeuroSpin, Hadrontherapy centre)Europe has developed large scale projects (NoE, IP) in FP6 Interface with life sciences is being structuredAppointment of chargs de mission at CEA-DAPNIA (P. Le D, P. Mangeot) and a scientific deputy director in charge of interdisciplinary activities at IN2P3 (E. Suraud)Research Group (GDR) Instrumentation and simulation for biomedical imaging started in 2005Involvement in european projects (CELLION, MAESTRO, EGEE, Embrace, BioinfoGRID)Bilateral collaborations with Germany, Austria, Korea,Tawan,

  • Scientific prospects for the next 10 yearsObjective 1: contribute to the next generation of FEL and to the R&D on the cold technology of the e+e- linear collider (TESLA)Objective 2: Contribute to the design and building of proton- and hadron-therapy centresObjective 3: Develop innovating imaging techniques in biology and medecine Objective 4: Contribute to emergence in France of multidisciplinary platforms based on ion beams for the irradiation and the modification of materials coupled with electron microscopes techniques or imaging systemsFrom Quarks to cosmos, scientific prospects of the next 10 years for nuclear and high energy physics of the IN2P3-CNRS and the DAPNIA-DSM-CEA, November 2005

  • Highlight within objective 2 : the ETOILE projectGoal: build a national centre for light-ion hadrontherapy in FranceLocation: Lyon, Rhone-Alpes region Budget: 90M to build the centreA routine flux of 1000 patients per year will be reached after 3 years with an operation cost of 15 M Euro.S